ADVACAN 0.25MG TABLET

Introduction:

Advacan 0.25mg Tablet is an immunosuppressant medication containing the active constituent everolimus. It is used to prevent the body’s immune system from rejecting a transplanted kidney, liver, or heart. It is used in combination with other medicines. Talk to your doctor if you have had recent major surgery, unhealed wound following surgery, kidney disorders, liver problems, allergic conditions, or respiratory symptoms (wheezing, difficulty breathing, coughing) before taking this medicine. 

This medicine is not recommended for adolescents and children under the age of 18. You need to tell your doctor about all the medications you are taking recently before taking Advacan 0.25mg Tablet. You must limit your exposure to sunlight and UV light by wearing protective clothing and applying sunscreen frequently, as this medicine may increase the risk of developing cancers. Avoid taking grapefruit juice or grapefruit while taking this medicine. 

If you are a man wanting to father a child, you should discuss the treatment with your physician, as taking Advacan 0.25mg Tablet may reduce sperm production in men. Inform your physician if you have been told that you have an intolerance to some sugars, as this medicine contains lactose.

Uses of Advacan 0.25mg Tablet:

• Prevents rejection of transplanted organs

How Advacan 0.25mg Tablet works:

Advacan 0.25mg Tablet inhibits the protein interleukin (IL-2 and IL-5). This inhibits the activation and multiplication of B and T lymphocytes (cells that play a central role in the body’s immune system), thereby suppressing the immune function and preventing transplant rejection.

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Advacan 0.25mg Tablet out of sight and reach of children.
• Store below 25°C.

References:

1. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Targeted therapy: tyrosine kinase inhibitors, monoclonal antibodies and cytokines, 12th edition, 2011, 1743.
2. KD Tripathi, Essentials of Medical Pharmacology, Immunosuppressant drugs, 7th edition, 2013, 878 - 882.
3. Novartis Pharmaceuticals UK Limited, Electronic medicines compendium (emc), [ Revised on Nov 2020] [ Accessed on 30th June 2021], https://www.medicines.org.uk/emc/files/pil.1920.pdf

How to use Advacan 0.25mg Tablet:

Always take Advacan 0.25mg Tablet exactly as your doctor has told you. Do not crush or chew the tablets. In order to keep constant levels in your body, you should always take Advacan 0.25mg Tablet in the same way, either always with food or always on an empty stomach. Avoid taking grapefruit juice or grapefruit while taking this medicine.

Safety advice:

Pregnancy:

Use effective birth control during the treatment and for at least 8 weeks after stopping the treatment. Tell your doctor if you are pregnant or planning to get pregnant before taking Advacan 0.25mg Tablet. It will be given to you if clearly needed.

Breastfeeding:

You should not breastfeed while taking this medicine. Inform your doctor if you are breastfeeding before taking Advacan 0.25mg Tablet.

Liver:

You need to tell your doctor if you have any liver disorders before taking Advacan 0.25mg Tablet. Your doctor may modify the dose according to your liver condition.

Kidney:

You need to tell your doctor if you have any kidney disorders before taking Advacan 0.25mg Tablet. Your doctor will examine your kidney function before treatment.

Others:

• Limit your exposure to sunlight and UV light. Wear protective clothing and apply sunscreen frequently.
• Talk to your doctor if you have any intolerance to sugars, have had a recent major surgery or unhealed wound following surgery.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Infections, inflammation of the lungs
• Cancer
• Kidney damage
• Impotence
• Severe allergic reactions (swelling of face, lips, tongue, throat, difficulty swallowing)

Common:

• Low blood cell count
• High levels of fats and sugar in the blood
• Headache, anxiety, difficulty sleeping
• Nausea, vomiting
• Fever, coughing, breathlessness
• Stomach pain, diarrhea
• High blood pressure
• Accumulation of fluid in tissues
• Fast heartbeat
• Nose bleeds
• Pain in the mouth or throat, mouth sores
• Joint pain, muscle pain
• Menstrual disorders (absent or heavy periods)
• Rash, itching