Aphyren Capsule  contains an active component as acebrophylline. It is a medication used to manage respiratory conditions such as bronchial asthma and chronic obstructive pulmonary disease (COPD). It can alleviate symptoms associated with respiratory conditions, such as wheezing, coughing, shortness of breath, and chest tightness. Improving bronchodilation and reducing airway inflammation can help individuals experience fewer and less severe symptoms. This medication has improved lung function parameters such as forced expiratory volume in one second (FEV1) and peak expiratory flow rate (PEFR). These improvements indicate better respiratory function and can contribute to overall lung health.
Aphyren Capsule is often used with other respiratory medications, such as inhaled bronchodilators and corticosteroids. It can complement the effects of these medications and provide additional benefits regarding bronchodilation and mucus clearance. This medication should not be used in individuals with known hypersensitivity or allergy to Aphyren Capsule, theophylline, ambroxol, or other medication components. This medication can cause an increase in blood pressure. It should be used cautiously in individuals with uncontrolled hypertension (high blood pressure) or severe cardiovascular and renal disease patients. It is contraindicated in individuals with a history of seizures or seizure disorders, as well as those who are at a high risk of developing seizures. Aphyren Capsule is generally not recommended for use in infants under the age of 12 months due to limited safety and efficacy data in this age group.

Aphyren Capsule is used in the treatment of the following:

• Bronchial asthma
• Chronic obstructive pulmonary disease (COPD)

Aphyren Capsule contain theophylline and ambroxol. Theophylline is a bronchodilator that helps relax the muscles in the airways, allowing easier breathing. It also has anti-inflammatory effects on the respiratory system. Ambroxol, on the other hand, is a mucolytic agent that helps break down and thin the mucus in the airways, making it easier to cough up. By combining these two components, this medication aims to provide both bronchodilation and mucus clearance, thus improving symptoms associated with respiratory conditions.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Aphyren Capsule, reducing effectiveness by causing undesirable side effects.

• Stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

To use Aphyren Capsule, follow the instructions provided by your healthcare provider or as indicated on the medication label. Swallow them whole with a full glass of water, with or without food, as directed. The dosage and duration of treatment will depend on the type and severity of the infection.

Aphyren Capsule cause some side effects like all medications, although not everyone will experience them. 

Serious:

• Allergic reactions
• Skin rashes
• Fungal infections
• Cardiac arrhythmias
• Seizures

Common:

• Nausea
• Vomiting
• Stomach discomfort
• Abdominal pain
• Headache
• Tremors
• Palpitations

Inform your healthcare provider about any known allergies or sensitivities to Acebrophylline, as well as any other medications or substances you are currently taking. Additionally, disclose your medical history, especially if you have a history of kidney disease, liver disease, gastrointestinal disorders, or blood clotting disorders. Caution should be exercised in individuals with cardiac conditions, seizures, gastrointestinal disorders, hepatic or renal impairment, and dose adjustments or alternative treatments may be required. Pregnant and breastfeeding women should consult a doctor before taking it. It is crucial to complete the full course of treatment as prescribed and not to skip any doses, even if symptoms improve, to ensure the infection is fully treated. Geriatric and pediatric populations may require dosage adjustments. Consulting with a healthcare professional is crucial to ensure the safe and appropriate use of Aphyren Capsule.

1. KD Tripathi, Essentials of Medical Pharmacology, Drugs for cough and bronchial asthma, 7th edition, 2013, 219

2. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Pulmonary pharmacology, 12th edition, 2011, 1040-1044

3. La Renon Healthcare Private Limited, [ Accessed on 17th June 2023], https://www.larenon.com/wp-content/uploads/2020/06/1.-Aphyren-N-LBL_ctc.pdf