Aplet 60mg tablet is used to treat the following:

• Reduce thrombotic cardiovascular events, including stent thrombosis.
• Manage patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI).
• Treat unstable angina (UA).
• Address non-ST-elevation myocardial infarction (NSTEMI).
• Treat ST-elevation myocardial infarction (STEMI).

Prasugrel acts as an inhibitor of platelet activation and aggregation by irreversibly binding its active metabolite to the P2Y12 class of ADP receptors on platelets.

Before starting the Aplet 60mg tablet, talk to your doctor about all the medications you are taking. Certain drugs, such as other antiplatelet agents, anticoagulants, and nonsteroidal anti-inflammatory drugs (NSAIDs), can increase your risk of bleeding when used with Aplet 60mg tablet.

Always inform your healthcare provider about any supplements or over-the-counter medications to avoid potential interactions.

• Store Aplet 60mg tablet at room temperature between 20°C to 25°C.
• Keep it out of sight and reach of children and pets.
• Store it in the original container.
• Protect it from moisture, heat, and direct sunlight.

Start treatment with Prasugrel by taking a single 60 mg oral loading dose, followed by a maintenance dose of 10 mg daily. Patients should also take aspirin daily at a dose of 75 mg to 325 mg. You can take Prasugrel with or without food.

For patients weighing less than 60 kg, the 10 mg daily maintenance dose may lead to increased exposure to the active metabolite and a higher risk of bleeding. Consider reducing the maintenance dose to 5 mg for these patients, but be aware that the effectiveness and safety of this 5 mg dose have not been prospectively evaluated.

Like all medications, Aplet 60mg tablet can cause side effects, although not everyone who takes it will experience them.

Common side effects 

• Bleeding
• Bruising
• Nausea
• Abdominal pain
• Dizziness
• Headache
• Rash or itching

Serious side effects 

• Thrombotic thrombocytopenic purpura (TTP)
• Significant bleeding events
• Allergic reactions
• Severe gastrointestinal bleeding

Inform your doctor if you have a history of kidney or liver issues, as they may need to monitor you closely during treatment. Regularly check for gastrointestinal symptoms and stay hydrated to prevent dehydration. Report any skin reactions or symptoms of low blood cell counts to your healthcare provider immediately. Always disclose all other medications you are taking to avoid potential interactions. Use Aplet 60mg tablet during pregnancy only when necessary, and monitor for any allergic reactions; report any concerns without delay.

1. Ticagrelor or Prasugrel for Patients With Acute Coronary Syndrome Treated With Percutaneous Coronary Intervention: A Prespecified Subgroup Analysis of a Randomized Clinical Trial | Acute Coronary Syndromes | JAMA Cardiology | JAMA Network
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/022307s002lbl.pdf
3. https://www.ema.europa.eu/en/medicines/human/EPAR/efient
4. https://www.ncbi.nlm.nih.gov/books/NBK557427/