1. Treatment of serious infections caused by susceptible multidrug-resistant Gram-negative bacteria.

2. Management of complicated infections where beta-lactamase-producing organisms are suspected or confirmed.

Aztreonam works by inhibiting bacterial cell wall synthesis, leading to bacterial destruction. However, many resistant bacteria produce β-lactamase enzymes that can inactivate aztreonam. Avibactam blocks these enzymes, preventing the breakdown of aztreonam. This combination restores and extends antibacterial activity, allowing effective treatment of resistant infections.

1. Probenecid (Severe)
   Probenecid can reduce renal clearance of aztreonam, increasing drug levels in the blood and raising the risk of toxicity. Combined use is generally avoided.

2. Other Nephrotoxic Antibiotics, such as Aminoglycosides or Colistin (Severe)
   Using these medicines together may increase the risk of kidney damage. Kidney function should be closely monitored during combined therapy.

3. Loop Diuretics like Furosemide (Moderate)
   Concurrent use may add to kidney stress, especially in critically ill patients. Regular monitoring of renal function is advised.

4. Oral Anticoagulants such as Warfarin (Moderate)
   Broad-spectrum antibiotics can alter gut flora and affect clotting control. INR monitoring is recommended during and after therapy.

5. Live Bacterial Vaccines such as Oral Typhoid (Moderate)
   Antibiotic therapy may reduce vaccine effectiveness. Vaccination should be delayed until antibiotic treatment is completed.

6. Sodium-containing IV Medicines (Mild)
   Emblaveo contains sodium, and combined use with other sodium-rich infusions may require monitoring in patients with heart or kidney conditions.

Store Atrenem AV Injection as directed on the label.

• Keep in a cool and dry place.

• Protect from excessive heat and moisture.

• Keep out of reach of children.

Dispose of unused medicine according to medical waste guidelines.

Atrenem AV Injection is administered as prescribed by a healthcare professional, usually in a hospital or clinical setting. The dose and duration depend on the type and severity of infection, kidney function, and patient response. Do not miss doses and complete the full course even if symptoms improve earlier.

Emblaveo powder side effects, although not everyone experiences them.

Serious:
Severe allergic reactions
Severe diarrhea or colitis
Kidney function impairment

Common:
Nausea
Vomiting
Diarrhea
Headache
Infusion site reactions
Changes in laboratory parameters

1. Take the medicine exactly as prescribed by your doctor.

2. Do not stop treatment early, even if symptoms improve.

3. Inform your doctor immediately if you develop a rash, breathing difficulty, or severe diarrhoea.

4. Ensure regular monitoring if you have kidney-related conditions.

5. Avoid self-medication and sharing this medicine with others.