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Augplat 125mg Injection
Salt Composition : Romiplostim
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
Introduction to Augplat 125mg Injection
Augplat 125mg injection belongs to the platelet-stimulating agent category, containing the active ingredient Romiplostim. It treats immune primary thrombocytopenia (ITP). ITP occurs when the body's immune system mistakenly attacks and destroys its own platelets, leading to low platelet counts. This drug is mostly used in adults and children aged 18 years and over with immune primary thrombocytopenia when other treatments have not been effective. It is prescribed when immunoglobulins, corticosteroids, or splenectomy (surgical spleen removal) have not successfully increased platelet counts.
This drug is contraindicated in individuals with known hypersensitivity or allergic reactions to other medicines that are produced by DNA technology using the micro-organism Escherichia coli (E. coli). Before receiving this injection, it is important to inform your physician about certain conditions such as liver problems, cancer, recent surgery, smoking habits, and if you are taking birth control pills. These factors may impact the safety and effectiveness of the medication, and your physician needs to be aware of them to determine if Augplat 125mg injection is suitable for you or if any adjustments need to be made to your treatment plan.
When you are on treatment with this drug, your physician will monitor your blood tests regularly to assess for any abnormalities that may indicate bone marrow changes. If abnormalities are detected, your doctor will evaluate their significance and determine the appropriate course of action because this drug has been associated with major changes in the bone marrow. Depending on the findings, your doctor may decide to continue or discontinue the treatment. Augplat 125mg injection is not recommended for pregnant patients unless specifically indicated by your doctor. Inform your physician if you are pregnant, suspecting, or planning for the pregnancy before initiating the treatment. It is not known whether this drug is present in human milk. Therefore breastfeeding should be avoided.
Uses of Augplat 125mg Injection
- Treatment of immune thrombocytopenia (ITP)
Therapeutic Effects of Augplat 125mg Injection
Augplat 125mg injection works by stimulating the production of platelets in the bone marrow. It binds to and activates the thrombopoietin receptor, which promotes the development and maturation of platelets. This helps to increase the platelet count in individuals with ITP.
Interaction of Augplat 125mg Injection with other drugs
Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Augplat 125mg injection and reduce effectiveness by causing undesirable side effects.
More Information about Augplat 125mg Injection
- Store Augplat 125mg injection in a refrigerator (2°C - 8°C).
- Do not freeze.
How to consume Augplat 125mg Injection
Augplat 125mg injection will be administered to you by a healthcare professional in a hospital setting. It is usually administered as a subcutaneous injection (under the skin). Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.
Safety Advices for Augplat 125mg Injection
Augplat 125mg injection is not recommended for pregnant patients unless specifically indicated by your doctor. Inform your physician if you are pregnant, suspecting, or planning for the pregnancy before initiating the treatment.
It is not known whether Augplat 125mg injection is present in human milk. Therefore, this drug is not recommended for use while breastfeeding.
It is unknown whether Augplat 125mg injection is safe for patients with lung problems. Inform your physician if you have lung disease before starting the treatment.
It is unknown whether Augplat 125mg injection is safe for patients with liver problems. Inform your physician if you have liver disease before starting the treatment.
It is unknown whether consuming alcohol interacts with Augplat 125mg injection. Please consult your doctor for more advice.
Some side effects of Augplat 125mg injection may impair your ability to drive or operate machinery safely. It is advisable to discuss this with your doctor before engaging in such activities.
Side Effects of Augplat 125mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Loss of response
- Progression of Myelodysplastic syndromes
- Thromboembolic complications
- Higher risk of blood clots
- Headache, dizziness
- Allergic reaction
- Upper respiratory tract infection
- Joint pain, muscle pain
- Sleeping trouble
- Tingling or numbness of feet or hands
- Abdominal pain, diarrhea, indigestion
- Fever, cough
Word of Advice
Since Augplat 125mg injection affects platelet production, it's essential to take precautions to avoid injuries and bleeding. Be cautious when engaging in activities that may increase your risk of injury, and report any unusual bleeding or bruising to your physician.
Q 1. What precautions should be taken before using Augplat 125mg injection?
Before taking Augplat 125mg injection, it is important to inform your physician about any liver problems, history of cancer, recent surgeries, smoking habits, and the use of birth control pills. These factors may affect the safety and effectiveness of the medication, and your physician needs to be aware of them.
Q 2. What are the common side effects of Augplat 125mg injection?
The most common side effects of Augplat 125mg injection include headache and respiratory tract infections. However, side effects can vary from person to person. If you experience any concerning side effects or have any concerns, it is advisable to consult your physician.
Q 3. How is Augplat 125mg injection administered?
Augplat 125mg injection is administered through subcutaneous injections (under the skin). Your physician will provide the specific dosing and administration instructions.
Q 4. How does Augplat 125mg injection work?
Augplat 125mg injection works by stimulating the production of platelets in the bone marrow. It binds to and activates the thrombopoietin receptor, promoting platelet development and maturation. This helps to increase the platelet count in individuals with ITP.
Q 5. Can Augplat 125mg injection be used in children?
Augplat 125mg injection is approved for use in adults and children aged 18 years and over with immune primary thrombocytopenia (ITP) when other treatments are ineffective. The pediatrician will determine the dosing and administration.
Fact Box of Augplat 125mg Injection
Molecule name: Romiplostim
Therapeutic class: Platelet-stimulating agents
Pharmacological class: Thrombopoietin receptor agonists
Indications: Treatment of immune thrombocytopenia (ITP)
- Amgen Limited, Electronic medicines compendium (EMC), [ Revised on Oct 2021] [ Accessed on 14th July 2023],https://www.medicines.org.uk/emc/files/pil.567.pdf
- Amgen Inc, US Food and Drug Administration, [ Revised on Dec 2018] [Accessed on 14th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/125268s163lbl.pdf
- Douglas B.cines et al.; Safety and efficacy of romiplostim in splenectomized patients with primary immune thrombocytopenia; Haematologica; Published on August 2017; Accessed on 14th July 2023; https://www.haematologica.org/article/view/8154
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