AZAFECT 100MG INJECTION

Introduction:

Azafect 100mg Injection consists of the active ingredient Azacitidine. It is used for treating adults with blood conditions, namely Myelodysplastic syndrome (MDS), chronic myelomonocytic leukemia and Acute myeloid leukemia (AML) if they are considered ineligible for stem cell transplant.

In Myelodysplastic Syndrome, the bone marrow does not produce healthy blood cells due to its lack of function. Acute Myeloid Leukemia is a type of bone marrow cancer caused by the release of incompletely formed blood cells into the bloodstream. Chronic myelomonocytic leukemia is a rare form of blood cancer caused by an increased number of monocytes of the white blood cells.

Uses of Azafect 100mg Injection:

This medicine is indicated to treat the following conditions:

• Acute Myeloid Leukemia with 20-30% blasts in patients who are not eligible for Haemopoietic stem cell transplant
• High-risk Myelodysplastic syndrome (MDS)
• Chronic myelomonocytic leukemia.

How Azafect 100mg Injection Works:

Azafect 100mg Injection binds to RNA and DNA, interrupts their activity in actively multiplying cells and exhibits a toxic effect on cancer cells.

Interaction with Other Drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store at 25°C. Keep out of reach of children.

References:

1. K. Gaston and P.-S. Jayaraman, Transcriptional repression in eukaryotes: Repressors and repression mechanisms, Cellular and Molecular Life Sciences, [May 2003], 60(4):721-741, [Accessed on 5th Apr 2021], https://www.researchgate.net/publication/7094896_Transcriptional_repression_in_eukaryotes_Repressors_and_repression_mechanisms
2. Roman M. Shapiro & Alejandro Lazo-Langner, Systematic review of azacitidine regimens in myelodysplastic syndrome and acute myeloid leukemia, BMC Hematology, 2018 [Accessed on 3rd Apr 2021],  https://bmchematol.biomedcentral.com/articles/10.1186/s12878-017-0094-8
3. Bristol-Myers Squibb, Electronic Medicines Compendium (EMC), [Revised on Oct 2021] [Accessed on 2nd Dec 2021], https://www.medicines.org.uk/emc/files/pil.6468.pdf
4. Leukaemia Care, [Revised on Jul 2020] [Accessed on 2nd Dec 2021], https://media.leukaemiacare.org.uk/wp-content/uploads/Chronic-Myelomonocytic-Leukaemia-CMML-Web-Version.pdf

How to use Azafect 100mg Injection: 

Take Azafect 100mg Injection only under the supervision of your physician. Your physician will decide the dose based on your height, weight and general condition. Azafect 100mg Injection shall be given under the skin of your thigh, stomach or upper arm.

Safety Advice:

Pregnancy:

This medicine is not intended for use during pregnancy. Talk to your physician if you are pregnant or think you could be pregnant.

Breastfeeding:

Consult your physician for advice on taking this medicine if you are a breastfeeding mother.

Liver:

Inform your physician before you take this medicine if you are diagnosed with a tumor in the liver cells.

Kidney:

Consult your physician before beginning this treatment if you have kidney disease.

Driving: 

Exercise caution while driving and using machines during this treatment.

Allergies:

Inform your physician before beginning this treatment if you have experienced allergic reactions to Azacitidine or its ingredients.

Others:

• Inform your physician before you take this medicine if you have lung problems, breathing trouble, heart problems, or other health issues.
• Consult your physician and use an effective contraceptive during this treatment to prevent unwanted pregnancy.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Drowsiness
• Shivering
• Jaundice
• Stomach bloating
• Unusual bleeding or bruising
• Reduced urination
• Increased thirst
• Dizziness
• Confusion
• Chest pain
• Breathlessness
• Allergies

Common:

• Disturbances in the blood count (RBC, WBC, Platelets)
• Nausea, vomiting, diarrhea
• Constipation
• Tiredness
• Skin reaction like redness and pain at the site of injection
• Decreased appetite
• Pain in extremities
• Joint pain
• Stomach pain
• Headache
• Sore nose and throat
• Rashes

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