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Biovorin 15mg Tablet
Last updated on 22 Jun 2026 | 11:08 AM (IST)
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Biovorin 15 mg Tablet is a prescription medicine used to reduce the toxic effects of methotrexate and to treat methotrexate overdose in specific clinical settings. It contains calcium folinate (leucovorin), which helps protect healthy cells. Biovorin is used under specialist supervision, especially in oncology care.
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Introduction to Biovorin 15mg Tablet
Biovorin 15mg tablet is an anticancer drug belonging to the class of detoxifying agents, containing the active ingredient Calcium Leucovorin/Calcium Folinate. It is used in the treatment of megaloblastic anaemia (the presence of large, immature, and dysfunctional red blood cells (megaloblasts) in the bone marrow). It is also used to enhance the effectiveness of 5-fluorouracil in the treatment of certain cancers, by increasing the efficacy of the drug while reducing its toxicity. This drug can also be used in the treatment of overdosage of folic acid antagonists. Additionally it also helps to protect healthy cells by "rescuing" them from the toxic effects of the chemotherapy drug.
This drug is contraindicated in patients who have hypersensitivity reactions. This medicine may cause allergic reactions in some people. Symptoms of an allergic reaction include itching, difficulty breathing, swelling of the face or throat, and a rapid heartbeat. If you experience any of these symptoms, consult your doctor immediately. Excessive Biovorin 15mg tablet doses must be avoided since this might impair the antitumor activity of methotrexate, especially in CNS tumours where calcium folinate accumulates after repeated courses.
There are no indications that folic acid induces harmful effects if administered during pregnancy and it is not known whether this drug can cause foetal harm, when administered to pregnant women. This drug should be used during pregnancy only when clearly needed. This medicine can be used during breastfeeding when considered necessary according to the therapeutic indications. Tell your physician about all the medications you have been taking recently, including herbal medicines and supplements, before taking Biovorin 15mg tablet.
Uses of Biovorin 15mg Tablet
- Treatment of Megaloblastic Anaemia
- Reduce the toxicity of methotrexate
- Overdose of Folic Acid Antagonists
- Enhance the effectiveness of 5-fluorouracil
Therapeutic Effects of Biovorin 15mg Tablet
Biovorin 15mg tablet works by enhancing the effects of folic acid in the body. It is taken up by cells through a specific transporter protein and converted into the active form of folic acid, which can be used by cells to produce DNA and form new cells. This drug is given after methotrexate to help rescue normal cells that require folate for their growth.
Interaction of Biovorin 15mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Biovorin 15mg tablet and reduce effectiveness by causing undesirable side effects.
More Information about Biovorin 15mg Tablet
- Store Biovorin 15mg tablet at room temperature below 25°.
- Keep it out of reach from children and pets.
How to consume Biovorin 15mg Tablet
Take Biovorin 15mg tablet exactly as prescribed by your doctor. Do not self-administer this medicine. Do not crush or chew the tablet. Do not exceed the recommended dosage. The dose of the biovorin 15mg tablet will be decided by your doctor based on your disease condition and other factors.
Safety Advice for Biovorin 15mg Tablet
Breast Feeding
It is not known if Biovorin 15mg tablet passes into your breast milk or if it will affect your baby. Please consult your doctor before breastfeeding.
Alcohol
It is unknown whether consuming alcohol interacts with the Biovorin 15mg tablet. Please consult your doctor for more advice.
Liver
Inform your doctor if you have any liver problems before taking Biovorin 15mg tablet. Regular monitoring of liver function tests is recommended.
Lungs
It is not known whether Biovorin 15mg tablet can be administered to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
It is completely safe to drive after taking the Biovorin 15mg tablet.
Pregnancy
It is not known whether Biovorin 15mg tablet can cause foetal harm, when administered to pregnant women. Consult your doctor if you are pregnant or planning for pregnancy during the treatment.
Side Effects of Biovorin 15mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Reduced number of blood cells
- Inflammation in the lining of mouth and intestine
- Severe allergic reactions
Common
- Nausea, vomiting, severe diarrhoea
- Redness and swelling of palms of hands and soles of feet
Word of Advice
Special care is needed if you are elderly and you are about to receive any fluorouracil treatment and Biovorin 15mg tablet at the same time in case you undergo radiotherapy or stomach trouble. Please tell your doctor if you are taking or have recently taken any other medicines, including medicines obtained without a prescription.
FAQs about Biovorin 15mg Tablet
Q1.
What are the special precautions I should be aware of before starting treatment with Biovorin 15mg tablet?
Biovorin 15mg tablet is eliminated from the body primarily through the kidneys. Patients with impaired kidney function may need a lower dose or less frequent dosing of this drug.
Q2.
Can Biovorin 15mg tablet be used in combination with other drugs?
Yes, Biovorin 15mg tablet is used as an antidote to reduce the toxic effects of methotrexate, a chemotherapy drug that is used to treat certain types of cancer.
Q3.
What does Biovorin 15mg tablet do to your body?
Biovorin 15mg tablet works by supplying the body with the necessary folate, which is required for the production of red blood cells, DNA synthesis, and other important cellular functions.
Q4.
When you must not be given Biovorin 15mg tablet?
Biovorin 15mg tablet should not be given to patients who have had an allergic reaction to it or any of its components.
Q5.
What is Biovorin 15mg tablet rescue?
Biovorin 15mg tablet rescue is typically used in cancer treatment, particularly in the treatment of leukaemia and lymphoma. This involves administering calcium folinate to patients who are receiving high-dose methotrexate treatment. The calcium folinate helps to reduce the toxic effects of methotrexate on healthy cells by providing a form of folic acid that can be used by the body to make new cells and DNA.
Q6.
Can I drive after receiving a Biovorin 15mg tablet injection?
It is generally safe to drive after receiving a Biovorin 15mg tablet. However, you may experience dizziness or drowsiness as a side effect, which may impair your ability to operate a vehicle or heavy machinery. It is important to wait until you feel fully alert and able to function normally before driving.
Fact Box of Biovorin 15mg Tablet
Molecule name: Calcium Leucovorin/Calcium Folinate | Therapeutic class: Anti-cancer |
Pharmacological class: Detoxifying agents | Indications: 1. Treatment of Megaloblastic Anaemia 2. Reduce the toxicity of methotrexate 3. Treatment of Overdosage of Folic Acid Antagonists 4. Enhance the effectiveness of 5-fluorouracil |
References
- Hospira UK Ltd, Electronic Medicines Compendium (EMC), [Revised on Feb 2021] [Accessed on 11th Apr 2023] https://www.medicines.org.uk/EMC/files/pil.1572.pdf
- Pfizer Singapore, [11th Sep 2018] [Accessed on 11th Apr 2023] http://labeling.pfizer.com/ShowLabeling.aspx?id=12130
- Package leaflet: Summary of the product characteristics for the user. www.hpra.ie.http://www.hpra.ie/img/uploaded/swedocuments/Licence_PA0749-001-001_01022022140623.pdf [Accessed on 11th Apr 2023]
- Calcium folinate sandoz - medsafe. Available at: https://www.medsafe.govt.nz/Consumers/CMI/c/calciumFolinateSandoz.pdf [Accessed on 11th Apr 2023]
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Bhairavi S
Pharm. D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 22 Jun 2026 | 11:08 AM (IST)
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