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BORTENAT 3.5MG INJECTION
Salt Composition : Bortezomib
Manufacturer : NATCO PHARMA LTD
Origin of Medicine : India
Introduction to Bortenat 3.5mg Injection
Bortenat 3.5mg Injection is a chemotherapy medication that belongs to the class of medicines called proteasome inhibitors. It consists of the active ingredient Bortezomib. It is indicated for the treatment of multiple myeloma and mantle cell lymphoma. Multiple myeloma refers to the cancerous progression of plasma cells that are predominant in the bone marrow. Mantle cell lymphoma is a less common cancer affecting the lymph nodes. This medication is concomitantly used with other chemotherapy medicines like pegylated liposomal doxorubicin, rituximab, cyclophosphamide, doxorubicin, dexamethasone, prednisolone or thalidomide for patients who have not started treatment and are ineligible for blood stem cell transplant.
The common side effects likely associated with Bortenat 3.5mg Injection are Pneumonia, loss of appetite, sensitivity, tingling and burning sensation of the skin, nausea, vomiting, diarrhea, mouth ulcers, constipation, muscle and bone pain, hair loss, fever, infections, itching, redness, dehydration, stomach problems, etc., Inform your physician if these side effects disturb or persist in you.
Inform your doctor if you are allergic to Bortenat 3.5mg Injection and its ingredients. Do not use this medication if you have severe lung or heart problems. Before starting treatment with this medication, let your physician know if you are suffering from neuropathy (nerves malfunction), cardiac disorders, severe lung problems, pulmonary disorders, posterior reversible encephalopathy syndrome disorders, gastrointestinal disorders, thrombocytopenia (a low platelet count), neutropenia (low white blood cell count), tumor lysis syndrome (metabolic abnormalities that can occur as a complication during the treatment of cancer), hepatic disorders. Inform your doctor of diabetes because this Injection can affect your blood glucose levels.
Uses of Bortenat 3.5mg Injection
- Treatment of multiple myeloma and mantle cell lymphoma.
Therapeutic Effects of Bortenat 3.5mg Injection
Bortenat 3.5mg Injection Injection works by exerting a toxic effect on cancer cells. It inhibits the 26S proteasome and blocks a major cell signaling pathway. This inhibition of the signaling pathway makes the cancer cells sensitive to chemotherapy. This medicine also enhances the build-up of a protein and minimizes cancer cell growth and multiplication.
Interaction of Bortenat 3.5mg Injection with other drugs
Inform your doctor about any prescribed medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products that you are taking or have taken before the treatment. Certain medications may interact with Bortenat 3.5mg Injection and may cause undesirable side effects.
More Information about Bortenat 3.5mg Injection
- Store unopened vials in the refrigerator (2 °C – 8 °C) and protect them from light.
- Keep this medicine out of sight and reach of children.
How to consume Bortenat 3.5mg Injection
Bortenat 3.5mg Injection is administered intravenously in your vein or subcutaneously under the skin. This injection should be given by a qualified healthcare professional experienced in the use of cytotoxic medications. Do not self-administer.
Safety Advices for Bortenat 3.5mg Injection
Bortenat 3.5mg Injection is unsafe to use during pregnancy unless clearly necessary. Both women of childbearing potential and men must use an effective contraception method during and three months after treatment.
Bortenat 3.5mg Injection is unsafe to use during breastfeeding. Please discuss with your physician when it is safe to restart breastfeeding after this treatment.
It is unknown whether Bortenat 3.5mg Injection can be given to lung failure patients. Please consult your physician if you have any lung diseases.
Inform your physician before starting this treatment if you have Hepatitis infection or liver disease. Your physician will monitor your liver functions regularly.
It is unsafe to consume alcohol with this medication. Bortenat 3.5mg Injection may cause excessive drowsiness with alcohol. Please consult your doctor for more advice.
Avoid driving or using machinery if you experience side effects like fainting, dizziness, tiredness, or blurred vision.
Side Effects of Bortenat 3.5mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Muscle cramps
- Confusion, visual disturbances, seizures, and headache
- Swelling of feet
- Changes in heartbeat
- High blood pressure
- Fainting and tiredness
- Cough and chest tightness
- Loss of appetite
- Sensitivity, tingling and burning sensation of the skin
- Nausea, vomiting, and diarrhea
- Mouth ulcers
- Muscle and bone pain
- Hair loss
- Reduction in blood cell count
- Reduced kidney function
- Itching and redness
- Stomach problems
- Difficulty sleeping, anxiety, mood swings, depressed mood
Word of Advice
It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Bortenat 3.5mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with bortezomib to check your blood cell counts regularly. Pregnant women should not handle this Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.
Q 1. What is Bortenat 3.5mg Injection used for?
Bortenat 3.5mg Injection is mainly indicated to treat mantle cell lymphoma and multiple myeloma.
Q 2. Can I drive while taking Bortenat 3.5mg Injection?
Bortenat 3.5mg Injection may cause dizziness, tiredness, fainting, or blurred vision. Hence, avoid driving and operating heavy machines while this Injection.
Q 3. How is Bortenat 3.5mg Injection given?
Bortenat 3.5mg Injection is administered intravenously in your vein or subcutaneously under the skin by a doctor in a medical facility.
Q 4. Is it safe to handle Bortenat 3.5mg Injection while pregnant?
No, Pregnant women should not handle Bortenat 3.5mg Injection as it contains cytotoxic agents. Using gloves and protective clothing is recommended to prevent skin contact.
Q 5. What class of chemo is Bortenat 3.5mg Injection?
Bortenat 3.5mg Injection is a targeted therapy that belongs to the class of medicines called proteasome inhibitors.
Q 6. Can I take Bortenat 3.5mg Injection when I am pregnant?
Avoid taking Bortenat 3.5mg Injection if you are pregnant, as it can cause harmful effects on the unborn baby. Females should use effective birth control methods during treatment and at least three months after treatment.
Q 7. I am suffering from a Hepatitis infection. Can I take Bortenat 3.5mg Injection?
Bortenat 3.5mg Injection should not be used in patients with hepatitis infection because they might have a repeated attack of hepatitis, which can be fatal. If you have a history of hepatitis B infection, your doctor will carefully check you for signs of active hepatitis B.
Fact Box of Bortenat 3.5mg Injection
Molecule name: Bortezomib
Therapeutic class: Antineoplastics agents
Pharmacological class: Proteasome inhibitor
1. Multiple myeloma
2. Mantle cell lymphoma
- STADA, Electronic Medicines Compendium (EMC), [Revised on Nov 2021] [Accessed on 30 Nov 2022], https://www.medicines.org.uk/emc/files/pil.10201.pdf
- Takeda Pharmaceuticals U.S.A., Inc., [Revised on Aug 2022] [Accessed on 30 Nov 2022], https://www.velcade.com/files/pdfs/VELCADE_PRESCRIBING_INFORMATION.pdf
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
- H.G. Watson, J.I.O. Craig, L.M. Manson, Blood disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 989-1056
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