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Buselin 7mg Injection
Salt Composition : Buserelin
Manufacturer : SAMARTH LIFE SCIENCES PVT LTD
Origin of Medicine : India
1 Ampoule(s) Of 7ml
Introduction to Buselin 7mg Injection
Buselin 7mg Injection is an anticancer drug belonging to the category of gonadotropin releasing hormone analogues, containing the active ingredient Buserelin. It is used in the treatment of advanced prostatic carcinoma(a type of prostate cancer that has spread outside of the prostate gland). It is also used in the treatment of endometriosis (is a condition in which the tissue that normally lines the inside of the uterus (endometrium) grows outside of it). This drug is also treated for the adjunctive use in ovulation induction.
If you experience any pain, swelling, feeling of tension in your stomach, feel sick, gain weight, diarrhoea, difficulty breathing, or passing less urine. These could be signs of a serious side effect called “Ovarian Hyperstimulation Syndrome (OHSS)”, so it is advised to inform your doctor immediately if all these symptoms exist. Incase of ectopic pregnancies, miscarriages or multiple pregnancies this drug can be used as adjunctive therapy. This drug may reduce the effect of drugs used to treat high blood pressure, and diabetes. It is recommended to monitor the blood pressure and blood glucose levels regularly to prevent complications. In addition, changes in blood lipids, increase in bilirubin levels, increase in serum liver enzymes levels (e.g. transaminases), leucopenia, thrombopenia have been observed with the use of this medicine. Talk to your doctor if you take any other medications or before using over-the-counter medicines or herbal products. Your doctor will evaluate the risk of interaction with this medication.
Consult your doctor before using this medication if you are pregnant or plan to have a baby. This injection is unsafe to use during pregnancy as it causes harm to an unborn fetus. Your health care practitioner will conduct a pregnancy test before you start treatment with Buselin 7mg Injection. Discuss with your doctor effective birth control methods and utilise them for at least two weeks following the last dose. Breastfeeding should be avoided during the treatment with this drug as it may pass into breast milk in small amounts. This drug must not be given to premature or newborn babies because it contains benzyl alcohol which may cause toxic reactions and allergic reactions in infants and children up to 3 years old. You may feel dizzy, drowsy or have blurred eyesight while using this medicine. If this happens, do not drive or use any tools or machines.
Uses of Buselin 7mg Injection
- Advanced prostatic carcinoma
- Treatment of endometriosis
- Adjunctive use in ovulation induction
Therapeutic Effects of Buselin 7mg Injection
It works by reducing the production of certain hormones in the body. This drug specifically gets binding to and stimulating GnRH receptors in the pituitary gland, which is located at the base of the brain. This leads to a transient increase in the production and release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. However, with continued use, this injection suppresses the production of LH and FSH, leading to a decrease in the production of testosterone in men and estrogen in women.
Interaction of Buselin 7mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Buselin 7mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Buselin 7mg Injection
- Store Buselin 7mg Injection in a controlled room temperature (15°C to 25°C).
- Do not freeze.
- Keep it out of reach from children.
How to consume Buselin 7mg Injection
The medicine will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an injection under the skin (subcutaneously) or as a nasal spray. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors.
Safety Advices for Buselin 7mg Injection
Buselin 7mg Injection is unsafe for pregnant women as it may harm the unborn baby.
Buselin 7mg Injection is not recommended in breastfeeding women as it may pass into the breast milk.
It is unknown whether Buselin 7mg Injection can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
It is unknown whether Buselin 7mg Injection can be used for patients with liver disorders. Consult your doctor if you have any liver diseases before starting the treatment.
It is unknown whether consuming alcohol interacts with the Buselin 7mg Injection. Please consult your doctor for more advice.
It is unsafe to drive vehicles or operate heavy machinery after taking the Buselin 7mg Injection.
Side Effects of Buselin 7mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Allergic reactions like difficulty swallowing, rashes and swelling
- Pain and stomach problems
- Weight gain
- Low urination
- High BP
- Unusual bruising
- Severe headache and eyesight problems
- Menopause-like symptoms
- Increased sweating, dry vagina, hot flushes
- Shoulder pain and stiffness
- Constipation or diarrhea
- Low glucose tolerance
- Mood changes, depression, anxiety
- Heart palpitations
- Hair loss
- Vaginal discharge
- Changes in liver enzymes
Word of Advice
It is recommended to quit smoking or limit tobacco use while taking this medication. Smoking may also worsen some of the side effects of this injection, such as the risk of cardiovascular disease. Avoid drinking grapefruit juice with this medicine as it may increase the levels of buserelin in the body, which can develop the risk of side effects. Buselin 7mg Injection may cause dizziness, drowsiness, or blurred vision, so it is important to avoid driving. If you miss a dose of this injection and it is close to the time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule.
Q 1. How is Buselin 7mg Injection administered?
Buselin 7mg Injection is usually administered as an injection under the skin (subcutaneously) or as a nasal spray.
Q 2. What happens if I miss my Buselin 7mg Injection?
If you miss a dose of Buselin 7mg Injection and it is close to the time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule.
Q 3. What is the purpose of Buselin 7mg Injection?
Buselin 7mg Injection is a synthetic form of gonadotropin-releasing hormone (GnRH), which is a hormone produced naturally in the brain that helps to regulate the production of sex hormones in the body.
Q 4. Can Buselin 7mg Injection be given during pregnancy?
No, Buselin 7mg Injection can cause harm to a developing fetus and should not be given during pregnancy.
Q 5. Who should not use Buselin 7mg Injection?
Buselin 7mg Injection is not recommended for people who are allergic to this drug, or any of its ingredients. Also, women who are pregnant or breastfeeding should avoid taking it, because this medicine can harm an unborn baby or pass into breast milk.
Q 6. What should I avoid while taking Buselin 7mg Injection?
It is recommended to quit smoking or limit tobacco use while taking this medication. Smoking may also worsen some of the side effects of Buselin 7mg Injection, such as the risk of cardiovascular disease.
Fact Box of Buselin 7mg Injection
Molecule name: Buserelin
Therapeutic class: Anticancer
Pharmacological class: Gonadotropin releasing hormone analogues
1.Advanced prostatic carcinoma
2.Treatment of endometriosis
3.Adjunctive use in ovulation induction
- Neon Healthcare Ltd., Electronic Medicines Compendium (EMC), [Revised on Oct 2020] [Accessed on 11th April 2023], https://www.medicines.org.uk/emc/files/pil.11243.pdf
- Sanofi-Aventis Canada Inc, [Revised on Aug 2010], https://www.oncozine.com/wp-content/uploads/2017/07/Suprefact%C2%AE-buserelin-acetate.pdf [Accessed on 11th April 2023]
- Suprefact® 1 mg/ML solution for injection - hpra.ie. Available at: https://www.hpra.ie/img/uploaded/swedocuments/2160255.PA0540_074_001.718e6dbb-66a2-4c24-a718-2253b059c0d3.000001529108_Suprefact%C2%AE%201%20mgml.150821.pdf [Accessed on 11th April 2023].
- M.W.J. Strachan, J. Newell-Price, Endocrine disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 733-796.
- Roger K. Long, Hakan Cakmak, Hypothalamic & Pituitary Hormones, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 667-686.
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