BUSELIN 7MG INJECTION

Introduction:

Buselin 7mg Injection consists of the active ingredient Buserelin. It is indicated for the treatment of infertility, endometriosis in women and hormone-dependent prostate cancer in men. It belongs to a group of drugs called as Gonadotropin-releasing hormone analogs. Infertility in women results from abnormalities in the reproductive tract that prevent fertilization or embryonic implantation and damaged fallopian tubes due to infections. 

Buselin 7mg injection is approved as a part of androgen deprivation therapy, a combination of radiation, surgical and hormonal therapy in high-risk patients with prostate cancer. Androgen deprivation therapy lowers the levels of testosterone considerably. 

Uses of Buselin 7mg Injection:

• Treatment of infertility.
• Initial and maintenance treatment of advanced prostate cancer.
• Treatment of endometriosis in patients who do not require surgery.

How Buselin 7mg Injection works:

Buselin 7mg Injection functions as the Gonadotropin-releasing hormones that occur naturally in the body. It stimulates ovulation by inhibiting hormones that disrupt the process of ovulation.

In prostate cancer, this injection significantly raises the serum testosterone levels in the first few days and falls to the hypogonadal range within two weeks.

In males, the release of gonadotrophin causes reduced synthesis of testosterone, whereas, in females, it inhibits the secretion of estrogen.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Do not store above 25°C. Do not freeze. Use within 15 days of opening.

References:

1. Neon Healthcare Ltd., Electronic Medicines Compendium (EMC), [Revised on Oct 2020] [Accessed on 16th Jun 2021], https://www.medicines.org.uk/emc/files/pil.11243.pdf
2. Sanofi-Aventis Canada Inc, [Revised on Aug 2010] [Accessed on 16th Jun 2021], https://www.oncozine.com/wp-content/uploads/2017/07/Suprefact%C2%AE-buserelin-acetate.pdf
3. M.W.J. Strachan, J. Newell-Price, Endocrine disease, Davidson’s Principles & Practice of Medicine, 22nd Edition, 2014, 733-796.
4. Roger K. Long, Hakan Cakmak, Hypothalamic & Pituitary Hormones, Lange's Basic & Clinical Pharmacology, 14th Edition, 2018, 667-686.

How to use Buselin 7mg Injection:

This injection should be administered by a qualified healthcare professional. Your physician will educate you on the method of administering this injection.

Safety Advice:

Pregnancy:

This injection might be harmful to the developing baby. Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. 

Breastfeeding: 

Breastfeeding during this treatment may not be safe. Your physician might suggest you to stop breastfeeding for some time, depending on your condition.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Your physician will monitor your liver functions regularly.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will monitor your kidney functions regularly.

Driving: 

This injection could cause dizziness, drowsiness, or blurred eyesight. Avoid driving or using machinery if you experience side effects.

Allergies: 

Inform your physician if you experience allergic reactions to Buserelin, Goserelin or its ingredients.

Others:

• Inform your physician before starting this treatment if you have polycystic ovarian disease or abnormal menstrual bleeding.
• Inform your physician if you have diabetes, High BP, bone disorders, etc. Consult your physician if you have heart problems.
• Your physician will not prescribe you this injection if your prostate cancer is hormone-independent.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Allergic reactions like difficulty swallowing, rashes and swelling
• Diarrhea
• Pain and stomach problems
• Breathlessness
• Weight gain
• Low urination
• Sickness
• High BP
• Unusual bruising
• Severe headache and eyesight problems
• Infections

Common:

• Menopause-like symptoms
• Increased sweating, dry vagina, hot flushes
• Shoulder pain and stiffness
• Constipation or diarrhea
• Low glucose tolerance
• Mood changes, depression, anxiety
• Tinnitus
• Heart palpitations
• Hair loss
• Vaginal discharge
• Changes in liver enzymes