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Caberz NB 40mg Tablet
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Introduction to Caberz NB 40mg Tablet
Caberz NB 40mg Tablet is an antineoplastic drug with an active ingredient called Cabozantinib. It belongs to the medication class known as tyrosine kinase inhibitors. In adults, it is used to treat advanced kidney cancer and locally advanced or metastatic differentiated thyroid cancer. It is also used in treating liver cancer when Sorafenib (anticancer medicine) is no longer working. Usually, this medicine is given in combination with Nivolumab for advanced kidney cancer. It is not recommended for those younger than 18 years.
Do not consume Caberz NB 40mg Tablet if you are allergic to Cabozantinib and its other ingredients. Inform your physician if you have liver disease, inflammatory bowel disease, high blood pressure, heart disease, or diarrhea. Notify your doctor about the history of blood clots in the leg or significant bleeding, aneurysm (inflammation of blood vessels), or tears in the blood vessel wall. Inform your physician if you are pregnant or planning to get pregnant. Use effective contraception during and even after the treatment or four months. Discuss more fertility concerns with your doctor.
Before starting with Caberz NB 40mg Tablet, notify your doctor if you have a thyroid problem; thyroid functions must be monitored before starting the medicine. Do not forget to inform your physician if you recently had any surgery, including dental surgery, within the last month. Avoid taking grapefruit or grapefruit juice during the treatment as they may increase the level of medicine in the blood. This medicine contains lactose; if you are intolerant to any sugar, inform your doctor before taking the medicine.
Uses of Caberz NB 40mg Tablet
The Caberz NB 40mg Tablet is used in the treatment of the following:
- Advanced renal cell carcinoma
- Liver Cancer
- Differentiated thyroid cancer
Therapeutic Effects of Caberz NB 40mg Tablet
It acts against a protein called receptor tyrosine kinases and interferes with cell signaling, ultimately stopping the growth and spread of cancer cells. Cazanat 40mg is indicated alone or in combination with Nivolumab.
Interaction of Caberz NB 40mg Tablet with other drugs
Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications such as antibiotics, St, John's Wort, Aliskiren and other medicine may interact with Cazanat 40mg and can cause undesirable side effects.
More Information about Caberz NB 40mg Tablet
- Keep out of sight and reach of pets and children
- Store protected from light at a temperature not exceeding 30°C.
How to consume Caberz NB 40mg Tablet
Take Caberz NB 40mg Tablet as advised by your physician. Usually, this medicine will be given once a day. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking this medicine if your doctor advises you to stop.
Safety Advice for Caberz NB 40mg Tablet
Breast Feeding
Taking Caberz NB 40mg Tablet while breastfeeding may be unsafe because it may affect the child. Do not breastfeed for at least four months after the treatment. Therefore, talk with your doctor to get more information.
Alcohol
It is unknown whether consuming alcohol while taking a Caberz NB 40mg Tablet is safe. Please speak with your physician.
Liver
Inform your physician if you have liver problems because Caberz NB 40mg Tablet should be used cautiously with this condition.
Lungs
It is unknown whether Caberz NB 40mg Tablet is safe to administer in patients with lung problems. Inform your physician if you have any lung disease before starting the treatment. Contact your doctor if you experience any lung-related symptoms.
Driving
While taking Caberz NB 40mg Tablet, it is unsafe to drive or use machines because it may cause nausea, changes in vision, vomiting, etc. Talk to your doctor for more information.
Pregnancy
Caberz NB 40mg Tablet is unsafe to use during pregnancy as it may harm the unborn baby. Report to your doctor if you are pregnant or think you may be pregnant or planning for the pregnancy before starting the treatment.
Side Effects of Caberz NB 40mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Caberz NB 40mg Tablet are:
- Gastrointestinal perforation
- Severe or uncontrollable bleeding
- Shortness of breath
- Nonhealing wound
- Pain in the mouth, jaw/teeth, hand, feet,
- Loss of consciousness,
- Drowsy
- Swelling or sores in the mouth
- Blood vomiting
- Black stools
- Blood in urine
- Headache
- Coughing blood
Common side effects of Caberz NB 40mg Tablet are:
- Dehydration
- Difficulty swallowing
- Ringing in the ears
- Blood clots in the veins
- Fluctuation in the blood sugar levels
- The lower level of albumin
- Electrolyte imbalance
- Increased levels of liver enzymes
- Elevated cholesterol levels in the blood
- Hair loss
- Changes in hair color
- Muscle spasm
- Skin thickening
- Dry skin
- Itching
- Protein in urine
Word of Advice
Oral contraception may be ineffective while under the treatment of Caberz NB 40mg Tablet. Discuss effective contraception methods with your doctor, along with fertility concerns. Inform your doctor if you have a thyroid problem; thyroid function should be monitored regularly before taking this medicine. Notify your doctor if your face gets colder or tired more commonly or if your voice deepens while taking this medicine. Do not stop the medicine until your doctor advises. Notify your doctor if you experience any serious side effects. You are doctor may change your dose or stop the treatment. Your doctor will inform you if you need any dose adjustments. This medicine is not recommended for children or adolescents.
FAQs about Caberz NB 40mg Tablet
Q1.
Can Caberz NB 40mg Tablet cause a lower level of albumin?
One of the common side effects of Caberz NB 40mg Tablet is the lower level of albumin. If you experience any side, contact your physician immediately.
Q2.
Is Caberz NB 40mg Tablet a chemotherapy drug?
Yes, Caberz NB 40mg Tablet is a chemotherapy medication that belongs to the group of Tyrosine kinase inhibitors.
Q3.
How can I manage diarrhea while taking Caberz NB 40mg Tablet?
If you experience diarrhea while taking Caberz NB 40mg Tablet, staying hydrated by drinking plenty of fluids is important. Your doctor may also recommend over-the-counter or prescription medications to help manage your diarrhea. If your diarrhea is severe or persistent, you should contact your doctor.
Q4.
Why is liver enzyme getting elevated during treatment with Caberz NB 40mg Tablet?
The reason for this elevation is not completely understood, but it is thought to be related to the drug's effects on certain enzymes involved in liver function. The elevation in liver enzymes is generally mild and temporary and typically resolves on its own or with dose adjustment of the Caberz NB 40mg Tablet.
Q5.
Why is it recommended to use effective contraception during the treatment of Caberz NB 40mg Tablet?
To avoid unwanted pregnancy, it is advised to use effective contraception. Oral contraception may be ineffective, so it is better to discuss effective contraception with your doctor.
Fact Box of Caberz NB 40mg Tablet
| Molecule Name: Cabozantinib | Therapeutic class: Antineoplastics |
| Pharmacological class: Tyrosine kinase inhibitor | Indications: 1. Advanced renal cell carcinoma 2. Liver Cancer 3. Differentiated thyroid cancer |
References
1. Ipsen Pharma, Electronic Medicines Compendium (EMC), [Revised on July 2022] [Accessed on 25th April 2023], Cabometyx 20 mg Film-coated Tablets - Summary of Product Characteristics (SmPC) - (emc) (medicines.org.uk)
2. Exelixis, Inc., [Revised on Oct 2020] [Accessed on 25th April 2023], https://www.cometriq.com/downloads/Cometriq_Full_Prescribing_Information.pdf
3. Gregory A. Brent and Ronald J. Koenig, Thyroid and Antithyroid Drugs, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 2018, 787-801.
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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