Capelieva 500mg Tablet is used to treat,

• Adjuvant colon cancer
• Metastatic colorectal cancer
• Metastatic breast cancer

Capelieva 500mg Tablet is prescribed alone and also in combination with other anticancer medications like Docetaxel and Oxaliplatin. It stops the growth of cancer cells by inhibiting the DNA synthesis. Capelieva 500mg Tablet gets converted into its active form called fluorouracil and interferes with cell signalling, ultimately preventing the multiplication of cancer cells. 

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Capelieva 500mg Tablet and reduce effectiveness by causing undesirable side effects. 

• Store Capelieva 500mg Tablet in the original package at room temperature (20°C to 25°C). Do not freeze.
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

Take a Capelieva 500mg Tablet as prescribed by your doctor. Do not crush or chew the tablet. If you miss a dose of this tablet, take it as soon as you can if it is within 12 hours of the missed dose. If it is over 12 hours since your missed dose, skip the missed dose and go back to your usual dosing times to avoid taking double doses. Call your doctor to ask about making up the missed dose.

Serious

• Severe bloody diarrhoea, abdominal pain
• Heart problems (chest pain, shortness of breath, feeling faint, irregular heartbeat, sudden weight gain)
• Loss of too much body fluid, kidney failure
• Serious skin and mouth reactions (skin peeling, blisters)
• Hand and foot syndrome (swelling, changes in sensation of hands and feet)
• Liver problems
• Decreased blood count

Common

• Loss of appetite
• Weight loss
• Insomnia, depression
• Headache, dizziness
• Eye irritation, redness, increased tears
• Inflammation of veins
• Runny nose, fever
• Infections
• Hair loss
• Pain in joints, back
• Dry mouth, indigestion
• Constipation

Capelieva 500mg Tablet causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. Store the drug in the original package at room temperature (25°C). Do not freeze. Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose. Avoid driving or operating heavy machines if you experience dizziness, nausea or tiredness while on treatment with Capelieva 500mg Tablet.

1. Morningside Healthcare Ltd, Electronic medicines compendium (emc), [ Revised on Feb 2021] [ Accessed on 9th March 2023], https://www.medicines.org.uk/emc/files/pil.11498.pdf 
2. Genentech USA, Inc, US Food and Drug Administration, [ Revised on March 2015] [ Accessed on 9th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020896s037lbl.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 864.
4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1698.