Celestrase 1 EP 500IU Injection is an immunomodulator with an active ingredient called Human C1-esterase inhibitor. It belongs to the medication group known as complement inhibitors. C1-esterase inhibitor is a naturally occurring human protein in the blood used to control inflammation and swelling. Insufficient levels of C1-esterase inhibitor in the bloodstream or malfunctioning C1-esterase inhibitor can lead to angioedema (swelling) with the symptoms of stomach pain, and swelling in the hands, face, eyelids, lips, tongue, genitals, larynx, or feet. This medicine prevents hereditary angioedema in adults, adolescents, and children (six years or above) by increasing the amount of C1-esterase inhibitors in the bloodstream. 

Do not take this medicine if you are allergic to Human C1-esterase or its other ingredients. Before starting the treatment, inform your doctor if you have or had a history of venous and arterial thromboembolic (blood clotting) conditions. Celestrase 1 EP 500IU Injection may increase the risk of infection (virus) as this is made from human blood or plasma. Inform your doctor if you are planning to get a vaccination against hepatitis A or B. Notify your doctor if you have an indwelling venous catheter (a plastic tube facilitates urine drainage from the bladder), atherosclerosis, using oral contraception (androgen), morbid obesity and immobility (have been on bedrest or are unable to move around for a long time). Inform your physician if you are pregnant or planning to get pregnant and if you are on a sodium diet, as this medicine contains sodium.

Prevent hereditary angioedema

Celestrase 1 EP 500IU Injection inhibits the complement system by binding to inactivate proteases which prevents an increase in vascular permeability. This regulates immune responses, preventing tissue damage and inflammation.

Inform your doctor about any prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products you take or have taken before the treatment. Certain medications may interact with Celestrase 1 EP 500IU Injection and can cause undesirable side effects.

• Keep out of sight and reach of pets and children.

• Store below 25°C.

• Do not freeze it.

The medicine will be administered to you by a healthcare professional in a hospital setting. It is usually administered as an intravenous injection into a vein. Your doctor will decide the dose, route of administration, and frequency based on your disease condition and other factors.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious

• Sudden wheeziness

• Difficulty in breathing

• Swelling of eyelids, face or lips, rash or itching

Common

• Headache

• Nausea

• Hypersensitivity

• Dizziness

• Vomiting

• Rashes or pain at the injection site

• Fever.

• Inform your doctor if you are taking any other medicines with Celestrase 1 EP 500IU Injection.

• Take the medication exactly as instructed by your healthcare provider.

• Do not exceed or skip doses without medical advice.

• Notify your doctor if you experience any serious side effects.

• Contact your doctor for additional information if needed.

• This medicine is made from human blood, so there is a risk of viral transmission.

• Manufacturers minimize this risk by:

• Testing plasma donors for various infectious agents.

• Performing viral inactivation during manufacturing.

• Discuss any concerns about safety with your healthcare provider.