Chemlet 2.5mg Tablet may be prescribed for:

• Early breast cancer: As adjuvant treatment in postmenopausal women with hormone receptor-positive breast cancer.

• Extended adjuvant treatment: In postmenopausal women who have previously completed standard treatment with tamoxifen.

• Advanced breast cancer: For first-line treatment of hormone receptor-positive or hormone receptor-unknown advanced breast cancer and for certain patients whose disease has progressed after previous anti-oestrogen treatment.

The choice of treatment depends on the type, stage and hormone receptor status of the breast cancer.

Chemlet 2.5mg Tablet contains Letrozole, which blocks an enzyme called aromatase. This enzyme helps the body produce oestrogen, particularly after menopause.

By reducing oestrogen production, Letrozole lowers the hormonal stimulation that can support the growth of certain breast cancer cells.

Tell your doctor about all medicines, supplements and herbal products you take.

• Tamoxifen: Taking Letrozole with tamoxifen may reduce the effectiveness of Letrozole.

• Oestrogen-containing medicines: Hormone replacement therapy and other oestrogen-containing treatments may reduce the effect of Letrozole.

• Other cancer medicines: Tell your doctor about all anticancer treatments you are receiving so that the treatment combination can be assessed.

• Medicines affecting bone health: Your doctor may review medicines and supplements used for bone health because long-term reduction in oestrogen can affect bone density.

• Store Chemlet 2.5mg Tablet below 30°C.

• Keep the tablets in their original packaging and protect them from moisture and direct light.

• Keep the medicine out of the reach of children.

Take Chemlet 2.5mg Tablet exactly as prescribed by your doctor.

• The usual dose is 2.5 mg once daily, but follow the regimen prescribed for you.

• It can be taken with or without food.

• Swallow the tablet whole with water. Do not crush or chew it.

• Try to take it at the same time each day.

• Do not stop treatment unless advised by your doctor.

• If you miss a dose, take it when you remember unless it is nearly time for your next dose. Skip the missed dose if necessary and continue with your regular schedule. Do not take two doses together.

Your doctor may monitor bone mineral density and cholesterol levels during treatment.

Common side effects

• Hot flushes

• Sweating

• Joint pain

• Muscle or bone pain

• Fatigue

• Headache

• Dizziness

• Nausea

• Swelling

• Increased cholesterol levels

Long-term treatment may reduce bone mineral density and increase the risk of osteoporosis and fractures.

Serious side effects

Seek medical attention if you develop:

• Severe allergic reactions such as swelling of the face, lips or throat

• Severe or persistent bone or joint pain

• Symptoms of a fracture

• Severe dizziness or weakness

• Significant liver-related symptoms such as yellowing of the skin or eyes

Your doctor may monitor your bone health and cholesterol during treatment.

• Take Chemlet 2.5mg Tablet regularly at the dose prescribed by your oncologist.

• Do not take oestrogen-containing medicines unless your doctor specifically advises them.

• Tell your doctor if you have osteoporosis or a history of fractures.

• Your doctor may recommend bone mineral density testing during treatment.

• Maintain adequate calcium and vitamin D intake if recommended by your doctor.

• Keep scheduled follow-up appointments and blood tests.

• Tell your doctor about any new or worsening bone or joint pain.

• Do not stop Chemlet without discussing it with your oncologist.