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Cizumab 300mg Injection
Prescription Required
Salt Composition : Bevacizumab
Manufacturer : HETERO HEALTHCARE LTD
Origin of Medicine : India
1 Vial(s)
Introduction to Cizumab 300mg Injection
Cizumab 300mg Injection is an anticancer medicine consisting of the active ingredient Bevacizumab. This medicine is developed to prevent the growth of tumours. It is indicated along with other chemotherapy drugs to treat metastatic breast cancer, brain cancer, cervical cancer, kidney cancer, lung cancer, and colorectal cancer. It is also used to treat cancers of the ovary, fallopian tube or primary peritoneal cancer. Use effective birth control during the treatment and for at least six months after the last dose.
Cizumab 300mg Injection is not recommended for adolescents and children under the age of 18. Discuss with your doctor about the preservation of ovaries if you are planning for pregnancy in the near future,e as this medicine may cause fertility issues in women. It would be best to avoid breastfeeding your baby as this medicine may interfere with growth and development.
Cizumab 300mg Injection is often administered as a combination with other chemotherapy agents. Constipation, appetite loss, runny nose, fever, skin problems, and weight loss are common side effects of Cizumab 300mg Injection. Before starting treatment with this medicine, let your doctor know if you have high blood pressure, high blood sugar, stomach disorders, or heart problems. This medicine should not be taken for 28 days before and after surgery as it is associated with poor wound healing and high bleeding complications. You are advised to report to your doctor if you have any dental issues that require surgery before taking this medicine. In case you develop any visual changes or confusion, report to your doctor to prevent complications.
Uses of Cizumab 300mg Injection
Cizumab 300mg Injection is indicated to treat the following conditions:
- Glioblastoma multiforme (brain cancer)
- Persistent, recurrent, or metastatic breast cancer
- Metastatic cervical cancer
- Advanced kidney cancer
- Metastatic colorectal cancer
- Advanced non-small-cell lung cancer
- Liver Cancer- Hepatocellular carcinoma
- Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer
Therapeutic Effects of Cizumab 300mg Injection
Cizumab 300mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumour. As a result, it slows down the rate of progression of cancer.
Lung Cancer:
Cizumab 300mg Injection is a monoclonal antibody that has been approved as a first-line treatment for non-small cell lung cancer. For Non-small lung cancer, VEGF and EGFR are the proteins that are involved in promoting tumour growth in lung cancer. Cizumab 300mg Injection binds to these proteins and prevents the spread of lung cancer to other parts.
Colorectal Cancer:
Cizumab 300mg Injection has been approved initially for treating colorectal cancer as this medicine works by inhibiting the growth of blood vessels within the tumours. Thereby it retards the growth of tumors in colorectal cancer. Also, the latest study has demonstrated that this medication has improved the overall survival rate of patients with advanced colorectal cancer.
Breast Cancer:
Cizumab 300mg Injection is used in the treatment of metastatic breast cancer along with chemotherapy medications. This medication works against the formation of blood vessels that feed the breast cancer tissue. By producing this action,it makes the breast cancer cells hard to survive and makes them vulnerable to chemotherapy.
Brain Cancer:
For treating brain cancer, Cizumab 300mg Injection is used along with other chemotherapy medication to prevent the recurrence of brain tumours. It is exhibited as a last resort for brain tumours.
Kidney Cancer:
Cizumab 300mg Injection is used in combination with interferon-alpha for the treatment of advanced kidney cancer. This medication is effective in metastatic kidney cancer because in this cancer, there is an overexpression of VEGF protein.
Ovarian/ fallopian/peritoneal cancer:
Cizumab 300mg Injection has been indicted for its use in treating stage iii and iv ovarian cancer, fallopian and peritoneal cancer, along with chemotherapy medications after the initial surgery. This medication can also be used as maintenance therapy or as first-line therapy for patients with platinum-sensitive or resistant chemotherapy patients.
Liver Cancer:
Cizumab 300mg Injection has been approved for its treatment of advanced liver cancer in combination with immunotherapy. Studies show that this advanced treatment can be used in the frontline for liver cancer as it has exhibited better survival rate in patients compared to the standard therapy.
Interaction of Cizumab 300mg Injection with other drugs
Inform your doctor about any medications you are taking or have taken before the treatment.
More Information about Cizumab 300mg Injection
- Store Cizumab 300mg Injection at 2˚C to 8˚C. Do not freeze or shake.
- Protect from light. Keep out of reach of children.
How to consume Cizumab 300mg Injection
Your physician or nurse will administer Cizumab 300mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.
Safety Advices for Cizumab 300mg Injection
Pregnancy
Inform your physician before starting your treatment with Bevacizumab Injection in case if you are pregnant or planning for pregnancy, as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.
Breast Feeding
It is recommended to avoid breastfeeding for a minimum of 6 months after your treatment with Cizumab 300mg Injection as this medicine may interfere with the growth of your child.
Lungs
Inform your physician before starting Cizumab 300mg Injection if you have lung disease to avoid any serious side effects.
Liver
Inform your physician before starting Cizumab 300mg Injection if you have liver disease to avoid any serious side effects.
Alcohol
Consult your doctor to know if it is safe to consume while you are on treatment with Cizumab 300mg Injection, as only limited studies are available.
Driving
Avoid driving or using machinery while you are on your treatment with Cizumab 300mg Injection as it is related to causing dizziness or sleepiness.
Side Effects of Cizumab 300mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
The side effects of Cizumab 300mg Injection are listed below:
Common:
- Headache
- Vision changes
- Confusion
- Severe allergic reactions
- High Blood pressure
- Delayed wound healing following surgery
- Protein in urine
- Severe infections
- Blood clots in arteries and blood vessels of lungs
- Gut perforation
- Nosebleeds and bleeding risk
- Heart problems with an increase in heart rate
- Mouth sores, dryness
- Shortness of breath
Rare:
- Numbness in hands or feet
- Weakness and lack of energy
- Diarrhoea, nausea, vomiting, abdominal pain
- Constipation
- Loss of appetite
- Weight loss
- Changes in taste and speech
- Decrease in counts of white blood cells
- Fever
- Dry skin
- Back pain
Word of Advice
It is vital to inform your physician before taking Cizumab 300mg Injection if you have the following conditions:
- Have conditions involving inflammation in the stomach (ulcer, colitis).
- Experience allergic reactions to Cizumab 300mg Injection or its ingredients.
- Have recently undergone surgery as it is associated with the risk of bleeding.
- Have diabetes, hypertension, or heart problems.
FAQs
Q 1. Is Cizumab 300mg Injection used as a standalone treatment in cancers?
Cizumab 300mg Injection is a recombinant monoclonal antibody that belongs to the immunotherapy class of cancer treatment. It can either be used as monotherapy or in combination with chemotherapy or immunotherapy medications to improve the overall survival rate.
Q 2. Is it safe for women to use Cizumab 300mg Injection?
For women with reproductive potential subjected to Cizumab 300mg Injection, it is advised to discuss with your doctor the effective birth control methods during the treatment. Also to be continued for a minimum of 6 months after the treatment course completion as this medicine may impair fertility.
Q 3. Is it safe to undergo surgery during the treatment with Cizumab 300mg Injection?
Cizumab 300mg Injection is associated with an increased risk of bleeding complications and poor wound healing. Hence, it is suggested to avoid planning for surgery and maintain an interval of 28 days before or after surgery.
Q 4. Do the side effects of Cizumab 300mg Injection last for a chronic period?
All the side effects that are relatively caused by Cizumab 300mg Injection occur until the drug concentration stays in the body. It is found that this medicine will be contained in our body for almost 4 months after the final dose.
Q 5. How is Cizumab 300mg Injection administered?
Cizumab 300mg Injection is given intravenously through infusion, and the amount of drug will be measured based on the patient’s body weight, height and age. The first dose will be administered for 90 minutes, and if well tolerated, the infusion time can be reduced to 30 minutes.
Q 6. Can I take Cizumab 300mg Injection if I am pregnant?
Inform your physician before starting your treatment with Cizumab 300mg Injection in case if you are pregnant or planning for pregnancy, as this medicine may cause harm to the unborn baby and interrupt the formation of blood vessels.
Fact Box of Cizumab 300mg Injection
| Molecule Name | Bevacizumab |
| Therapeutic Classification | Anticancer |
| Pharmacological Classification | VEGF Inhibitor |
| Indications | Lung cancer, brain cancer, breast cancer, colorectal cancer |
References
- Roche Products Limited, Electronic Medicines Compendium (EMC), [Revised on Jan 2022] [Accessed on 21/11/2022], https://www.medicines.org.uk/emc/files/pil.3885.pdf
- G.G. Dark, A.R. Abdul Razak, Oncology, Davidson's Principles & Practice of Medicine, 22nd Edition, 2014, 259-282.
- KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
- Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf
- Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html
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