Cizumab 300mg Injection is indicated to treat the following conditions:

• Glioblastoma multiforme (brain cancer)
• Persistent, recurrent, or metastatic breast cancer
• Metastatic cervical cancer
• Advanced kidney cancer
• Metastatic colorectal cancer
• Advanced non-small-cell lung cancer
• Liver Cancer- Hepatocellular carcinoma
• Cancers of the ovary, cervical, fallopian tube, or primary peritoneal cancer

Cizumab 300mg Injection is a recombinant humanized monoclonal antibody that works as a targeted therapy in the treatment of various advanced cancers. It produces its action by selectively binding to the protein called vascular endothelial growth factor A (VEGF-A), which is present in the lining of blood and lymph vessels in the body. It interrupts the interaction of VEGF-A with its receptors. This further inhibits the formation of blood vessels that supply oxygen and nutrients to the tumour. As a result, it slows down the rate of progression of cancer.

Lung Cancer:

Cizumab 300mg Injection is a monoclonal antibody that has been approved as a first-line treatment for non-small cell lung cancer. For Non-small lung cancer, VEGF and EGFR are the proteins that are involved in promoting tumour growth in lung cancer. Cizumab 300mg Injection binds to these proteins and prevents the spread of lung cancer to other parts.

Colorectal Cancer: 

Cizumab 300mg Injection has been approved initially for treating colorectal cancer as this medicine works by inhibiting the growth of blood vessels within the tumours. Thereby it retards the growth of tumors in colorectal cancer. Also, the latest study has demonstrated that this medication has improved the overall survival rate of patients with advanced colorectal cancer.

Breast Cancer:

Cizumab 300mg Injection is used in the treatment of metastatic breast cancer along with chemotherapy medications. This medication works against the formation of blood vessels that feed the breast cancer tissue. By producing this action,it makes the breast cancer cells hard to survive and makes them vulnerable to chemotherapy.

Brain Cancer:

For treating brain cancer, Cizumab 300mg Injection is used along with other chemotherapy medication to prevent the recurrence of brain tumours. It is exhibited as a last resort for brain tumours.

Kidney Cancer:

Cizumab 300mg Injection is used in combination with interferon-alpha for the treatment of advanced kidney cancer. This medication is effective in metastatic kidney cancer because in this cancer, there is an overexpression of VEGF protein.

Ovarian/ fallopian/peritoneal cancer:

Cizumab 300mg Injection has been indicted for its use in treating stage iii and iv ovarian cancer, fallopian and peritoneal cancer, along with chemotherapy medications after the initial surgery. This medication can also be used as maintenance therapy or as first-line therapy for patients with platinum-sensitive or resistant chemotherapy patients.

Liver Cancer:

Cizumab 300mg Injection has been approved for its treatment of advanced liver cancer in combination with immunotherapy. Studies show that this advanced treatment can be used in the frontline for liver cancer as it has exhibited better survival rate in patients compared to the standard therapy.

Inform your doctor about any medications you are taking or have taken before the treatment.

• Store Cizumab 300mg Injection at 2˚C to 8˚C. Do not freeze or shake.
• Protect from light. Keep out of reach of children.

Your physician or nurse will administer Cizumab 300mg Injection as an intravenous infusion. The infusion should be given immediately after the dilution.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

The side effects of Cizumab 300mg Injection are listed below:

Common:

• Headache 
• Vision changes 
• Confusion
• Severe allergic reactions 
• High Blood pressure 
• Delayed wound healing following surgery 
• Protein in urine 
• Severe infections
• Blood clots in arteries and blood vessels of lungs 
• Gut perforation 
• Nosebleeds and bleeding risk
• Heart problems with an increase in heart rate 
• Mouth sores, dryness 
• Shortness of breath 

Rare:

• Numbness in hands or feet
• Weakness and lack of energy
• Diarrhoea, nausea, vomiting, abdominal pain
• Constipation
• Loss of appetite
• Weight loss
• Changes in taste and speech
• Decrease in counts of white blood cells
• Fever
• Dry skin
• Back pain

It is vital to inform your physician before taking Cizumab 300mg Injection if you have the following conditions:

• Have conditions involving inflammation in the stomach (ulcer, colitis).
• Experience allergic reactions to Cizumab 300mg Injection or its ingredients.
• Have recently undergone surgery as it is associated with the risk of bleeding.
• Have diabetes, hypertension, or heart problems.

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3. KD Tripathi, Anticancer Drugs, Essentials of Medical Pharmacology, 8th Edition, 2019, 915-936.
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.
5. Roche Group, U.S FDA, [Revised on Jan 2021][ Accessed on 21/11/2022], https://www.gene.com/download/pdf/avastin_prescribing.pdf
6. Roche Group,Bevacizumab Injection, Indication,[Revised on 2020] [Accessed on 21/11/2022]https://www.avastin.com/patient/mcrc.html