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COMCAPSY 400MG/20MG TABLET_1
COMCAPSY 400MG/20MG TABLET_2
COMCAPSY 400MG/20MG TABLET_3
COMCAPSY 400MG/20MG TABLET_1
14% Off

Comcapsy 400mg/20mg Tablet

Prescription Required

Salt Composition : Capecitabine And Cyclophosphamide

Manufacturer : INTAS PHARMACEUTICALS LTD

Origin of Medicine : India

MRP: 843.04
Price :723
You Save :120 (14%)

10 Tablet(s) In A Strip

Out of Stock

Introduction to Comcapsy 400mg/20mg Tablet

Comcapsy 400mg/20mg Tablet is an anti-metabolite drug that contains the active ingredient Capecitabine and Cyclophosphamide. It belongs to the category of medicines known as nucleoside metabolic inhibitors and alkylating agents. This medication is used in combination with other anticancer drugs for the treatment of Metastatic colorectal cancer and breast cancer. Cancer is a disease in which cells multiply in an abnormal and uncontrolled manner. It is also used for the prevention of new occurrences of cancer in the colon after the complete removal of the tumor by surgery.

The common side effects that are likely to occur with this medicine are loss of appetite, headache, runny nose, fever, hair loss, and dry mouth. During the treatment, your doctor may periodically monitor your complete blood counts, and prothrombin time, INR, to prevent serious complications. Report to your doctor if you have been diagnosed with stomach ulcers, cataracts, lung disease, or problems in your heart, liver, skin, or kidneys. Tell your physician before you undergo eye surgery or dental procedures.  Inform your doctor if you have experienced any allergic or unusual reactions after taking this tablet. This medicine can cause fertility issues, inform your doctor about any fertility concerns you may have before starting treatment with this medicine.  

Comcapsy 400mg/20mg Tablet is not recommended for children and adolescents. Before taking this medicine, ask for physician advice if you are intolerant to sugars as this chemotherapy medication contains lactose. This drug will not be given if you have low white blood cell or platelet count, chickenpox, shingles, or enzyme DPD deficiency (dihydropyrimidine dehydrogenase). Take this medicine within thirty minutes of finishing a meal. This drug can cause fetal harm when administered to a pregnant woman.


Uses of Comcapsy 400mg/20mg Tablet

  • Adjuvant colon cancer
  • Metastatic colorectal cancer
  • Metastatic breast cancer

Therapeutic Effects of Comcapsy 400mg/20mg Tablet

Comcapsy 400mg/20mg is prescribed alone and also in combination with other anticancer medications like Docetaxel and Oxaliplatin. It stops the growth of cancer cells by inhibiting DNA synthesis. This drug gets converted into its active form called fluorouracil and interferes with cell signaling, ultimately preventing the multiplication of cancer cells. 


Interaction of Comcapsy 400mg/20mg Tablet with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Comcapsy 400mg/20mg Tablet and reduce effectiveness by causing undesirable side effects. 


More Information about Comcapsy 400mg/20mg Tablet

  • Store Comcapsy 400mg/20mg Tablet in the original package at room temperature (20°C to 25°C). Do not freeze.
  • Keep it out of reach from children and pets.
  • It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

How to consume Comcapsy 400mg/20mg Tablet

Take a Comcapsy 400mg/20mg Tablet as prescribed by your doctor. Do not crush or chew the tablet. If you miss a dose of this tablet, take it as soon as you can if it is within 12 hours of the missed dose. If it is over 12 hours since your missed dose, skip the missed dose and go back to your usual dosing times to avoid taking double doses. Call your doctor to ask about making up the missed dose. 


Safety Advices for Comcapsy 400mg/20mg Tablet

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Pregnancy

  

Comcapsy 400mg/20mg Tablet is not recommended for pregnant women as it may cause fetal harm.

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Breast Feeding

  

It is not known if Comcapsy 400mg/20mg tablet passes into your breast milk or if it will affect your baby or your breast milk. Talk to your doctor about the best way to feed your baby if you receive this drug.

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Lungs

  

It is not known whether Comcapsy 400mg/20mg tablet can be prescribed to patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.

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Liver

  

Inform your doctor if you have any liver disorders before taking Comcapsy 400mg/20mg tablet. Regular monitoring of liver function tests is recommended.

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Alcohol

  

It is unknown whether consuming alcohol interacts with Comcapsy 400mg/20mg tablet. Please consult your doctor for more advice.

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Driving

  

Comcapsy 400mg/20mg Tablet may cause drowsiness which can affect the patient’s ability to drive or use machines. Consult your doctor before you resume driving. 


Side Effects of Comcapsy 400mg/20mg Tablet

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them,

Serious

  • Severe bloody diarrhoea, abdominal pain
  • Heart problems (chest pain, shortness of breath, feeling faint, irregular heartbeat, sudden weight gain)
  • Loss of too much body fluid, kidney failure
  • Serious skin and mouth reactions (skin peeling, blisters)
  • Hand and foot syndrome (swelling, changes in sensation of hands and feet)
  • Liver problems
  • Decreased blood count

Common

  • Loss of appetite
  • Weight loss
  • Insomnia, depression
  • Headache, dizziness
  • Eye irritation, redness, increased tears
  • Inflammation of veins
  • Runny nose, fever
  • Infections
  • Hair loss
  • Pain in joints, back
  • Dry mouth, indigestion
  • Constipation

Word of Advice

Comcapsy 400mg/20mg Tablet causes skin dryness so it is advised to use an effective moisturiser for your skin. Ensure that you stay hydrated and maintain a balanced diet. Store the drug in the original package at room temperature (25°C). Do not freeze. Keep it out of reach from children and pets. It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose. Avoid driving or operating heavy machines if you experience dizziness, nausea, or tiredness while on treatment with this medicine.


FAQs

Q 1. Is Comcapsy 400mg/20mg tablet prescribed as a monotherapy?

Comcapsy 400mg/20mg tablet is prescribed as a monotherapy and also in combination with other anticancer agents like Docetaxel and Oxaliplatin to treat breast and colorectal cancer respectively.

Q 2. What tests are essential before starting treatment with Comcapsy 400mg/20mg tablet?

Before starting treatment with Comcapsy 400mg/20mg tablet, your healthcare provider will recommend tests for pregnancy, DPD deficiency (dihydropyrimidine dehydrogenase), prothrombin time, INR, kidney function tests and serum electrolytes.

Q 3. Is it safe to undergo a surgery during the treatment with Comcapsy 400mg/20mg tablet?

It is suggested to avoid planning for surgery while on treatment with Comcapsy 400mg/20mg tablet. Tell your physician before you undergo surgery or dental procedures.

Q 4. What should you do if you missed a dose of Comcapsy 400mg/20mg tablet?

If you missed taking a dose of Comcapsy 400mg/20mg Tablet, skip this dose. Do not take two tablets to make up for the missed dose. Report to your healthcare provider right away if you missed taking more than two doses of this drug.

Q 5. Who should not take Comcapsy 400mg/20mg tablet?

Comcapsy 400mg/20mg tablet is not recommended for people who are allergic to this drug, 5-fluorouracil and their ingredients. It is also contraindicated in people with severe kidney disease and DPD deficiency (dihydropyrimidine dehydrogenase).

Q 6. Can you smoke while on treatment with Comcapsy 400mg/20mg tablet?

It is not recommended to smoke cigarettes while on treatment with Comcapsy 400mg/20mg tablet as smoking can reduce the concentration of this drug in the body.

Q 7. How do you know if you have overdosed on Comcapsy 400mg/20mg tablet?

Watch out for symptoms like nausea, gastric irritation, diarrhea, vomiting, bleeding and seek immediate medical attention from a nearby healthcare facility.


Fact Box of Comcapsy 400mg/20mg Tablet

Molecule name: Capecitabine and Cyclophosphamide

Therapeutic class: 

1.Capecitabine-Anti-metabolite

2.Cyclophosphamide-Antineoplastics

Pharmacological class: 

1.Capecitabine-Nucleoside metabolic inhibitor

2.Cyclophosphamide-Alkylating agent

Indications: 

1.Adjuvant colon cancer

2.Metastatic colorectal cancer

3.Metastatic breast cancer


References

  1. Morningside Healthcare Ltd, Electronic medicines compendium (emc), [ Revised on Feb 2021] [ Accessed on 9th March 2023], https://www.medicines.org.uk/emc/files/pil.11498.pdf
  2. Genentech USA, Inc, US Food and Drug Administration, [ Revised on March 2015] [ Accessed on 9th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020896s037lbl.pdf
  3. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 864.
  4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Cytotoxic agents, 12th edition, 2011, 1698.

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