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Criznib Capsule
Last updated on 29 Jun 2026 | 03:18 AM (IST)
₹15650
MRP: ₹31300
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60 CAPSULE(s) IN A BOTTLE
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₹15650
MRP: ₹31,300.00
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Introduction
Criznib Capsule contains the active substance Crizotinib. It is an antineoplastic drug that belongs to the class of tyrosine kinase inhibitors. This medicine is prescribed to treat patients with a type of lung cancer called Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) that is locally advanced or metastatic (spread outside the lungs or to other parts of the body). Do not take this capsule if you are allergic to Crizotinib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have had kidney, stomach, heart, or liver problems.
Notify your doctor if you have reduced white blood cells, abnormal heart tracing after ECG, vision problems, or if you take other medications. Report your doctor immediately if you are planning to get pregnant or think you may be pregnant. Talk to your doctor about effective contraceptives. Use effective birth control during the treatment because oral contraception is ineffective with this medicine, and use it at least for 90 days even after completing the therapy with Criznib Capsule. It is advised to get suggestions about fertility concerns from your doctor. This medication is not recommended for adolescents and children under 18 years of age. Use sunscreen or protective clothing to cover the skin and protect it against sunburn. Criznib Capsule prices vary by seller and location. Crizalk substitutes include Xalkori, Alectinib, Ceritinib, Lorlatinib, and Brigatinib, which are also used for ALK-positive non-small cell lung cancer.
Uses
Criznib Capsule tablet uses are:
Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC)
How Criznib Capsule Capsule Works
Crizotinib is a tyrosine kinase inhibitor that works by blocking the activity of the anaplastic lymphoma kinase (ALK) protein. It specifically targets the abnormal protein and blocks its activity, slowing down or stopping the growth and spread of cancer cells.
Interaction of Criznib Capsule with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications such as Erythromycin, Diltiazem, Verapamil, and other medications may interact with Criznib Capsule and reduce its effectiveness by causing undesirable side effects.
Storage Conditions
Store at room temperature (15-30˚C) in the original container
Keep this medicine out of the sight and reach of children.
How to take Criznib Capsule Capsule
Take the Criznib Capsule capsules at about the same time each day. The recommended dose is one capsule of 250 mg taken orally twice daily. Swallow the capsules whole and do not crush, chew, dissolve, or open the capsules. Your physician will choose the Crizalk dosage and administration frequency based on the medical condition because it differs for each person.
Safety advice
Pregnancy
Criznib Capsule capsule is unsafe to use during pregnancy. Hence, check with your physician before taking this medicine if you are pregnant or think you might be pregnant.
Breast Feeding
It is unsafe to breastfeed while taking Criznib Capsule because it can cause toxicity to the baby. Consult your physician for more information.
Lungs
Inform your doctor immediately if you experience any symptoms such as lung inflammation, difficulty breathing, a cough with or without mucus, or fever while taking Criznib Capsule.
Liver
Inform your physician about any underlying liver disorders before taking Criznib Capsule, as this medication should be used with caution in patients with liver disease. Consult your physician before taking this medicine.
Alcohol
It is not known whether it is safe to consume alcohol with Criznib Capsule. Please consult your doctor.
Driving
It is unsafe to drive while taking Criznib Capsule because this medicine may cause dizziness and fatigue; avoid driving and operating machinery during this treatment.
Side Effects
Criznib Capsule side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
Pain in the right side of the stomach
Partial or full loss of vision
Lowered WBC
Low heart rate.
Swelling of the lungs.
Breathlessness
Cough with or without mucus
Common
Sensitivity to sunlight.
Diarrhea
Fever
Constipation
Nausea
Increased liver enzymes
Decreased appetite, Tiredness (fatigue)
Dizziness
Neuropathy (weakness, tingling, or numbness in the nerve)
Dysgeusia ( taste disorder)
Hypophosphataemia (low levels of phosphate in the blood)
Expert Tips
Blood Health: Inform your doctor if you notice a reduced number of white blood cells (leucopenia) or red blood cells (anaemia), which may cause pale skin, weakness, or breathlessness.
Heart Monitoring: Your doctor may suggest an electrocardiogram to check your heart function and detect any slower heart rate.
Dosage: Take Criznib Capsule every day exactly as prescribed by your doctor without missing doses.
Precautions: Limit sun exposure to avoid photosensitivity and inform your doctor if you experience stomach problems, ankle swelling, or other unusual symptoms.
FAQs
Q1.
Does Criznib Capsule cure cancer?
Criznib Capsule is not a cure for cancer, but it can help to slow down or stop the growth and spread of cancer cells, improving the overall survival and quality of life of patients with certain types of cancer.
Q2.
What should I do if I miss a dose of Criznib Capsule?
If you miss a dose of Criznib Capsule, you should take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular dosing schedule.
Q3.
What should I tell my doctor before taking Criznib Capsule?
Before taking Criznib Capsule, you should tell your doctor if you have liver or kidney problems, a history of heart disease, or are pregnant or planning to become pregnant.
Q4.
Why are there low levels of phosphate in the blood while taking Criznib Capsule?
The exact mechanism by which Criznib Capsule causes hypophosphatemia (low phosphate levels) is not fully understood, but it is thought to involve inhibition of enzymes involved in phosphate transport and metabolism.
Q5.
Can Criznib Capsule be used in combination with other cancer medications?
Criznib Capsule may be used in combination with the chemotherapy drugs Pemetrexed and Cisplatin in the first-line treatment of ALK-positive non-small cell lung cancer (NSCLC). It depends on the specific cancer diagnosis and treatment plan.
Fact Box
Molecule name: | Crizotinib |
Therapeutic class: | Antineoplastic drug |
Pharmacological class: | Tyrosine kinase inhibitors |
Indication: | Anaplastic lymphoma kinase (ALK) positive non-small cell lung cancer (NSCLC) |
References
David Eric Gerber, ECOG-ACRIN Cancer Research Group, ClinicalTrials.gov IDNCT02201992 [Accessed on 30th Mar 2021],
https://www.cancer.gov/about-cancer/treatment/clinical-trials/search/v?id=NCI-2014-01507&r=1
Pfizer, Electronic Medicines Compendium (EMC), [Revised on Jun 2022], [Accessed on 19th April 2023], ANNEX I (medicines.org.uk)
Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins, and Edward A. Sausville, Pathway-Targeted Therapies: Monoclonal Antibodies, Protein Kinase Inhibitors, and Various Small Molecules, Goodman & Gilman’s Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1203-1236.
Disclaimer
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Author Details
Written By
Dr. Vikas B S
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 29 Jun 2026 | 03:18 AM (IST)
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