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Dapaglyn S 5mg/50mg Tablet
Last updated on 03 Oct 2026 | 08:57 AM (IST)
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Introduction
Dapaglyn S 5mg/50mg Tablet contains active components Dapagliflozin and sitagliptin. These are two different medications used to treat type 2 diabetes mellitus. They work through different mechanisms and can be combined to help control blood sugar levels in certain patients. Dapagliflozin is a medication belonging to the class of drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. This helps to lower blood glucose levels and reduce the overall blood sugar burden in the body. Sitagliptin is a medication classified as a dipeptidyl peptidase-4 (DPP-4) inhibitor. It regulates blood glucose levels by stimulating insulin release and reducing glucagon production, a hormone that raises blood sugar. This medication can be particularly beneficial for overweight or obese individuals with type 2 diabetes, as it can help achieve and maintain a healthy body weight. It is indicated for treating type 2 diabetes only and should not be used to treat type 1 diabetes.
Individuals with known hypersensitivity or allergy to dapaglyn s 5 50 or other components of these medications should not take them. It is primarily eliminated through the kidneys. Therefore, individuals with severe renal impairment or end-stage renal disease should not use this medication. During periods of illness, surgery, or other stressful situations, there may be an increased risk of developing ketoacidosis, particularly in those taking dapagliflozin. Temporary discontinuation of this medication during such events may be necessary. There is limited data on the safety of Dapaglyn S Tablet during pregnancy and breastfeeding. Pregnant or breastfeeding individuals should consult their healthcare provider before using this medication.
Uses
Dapaglyn S 5mg/50mg Tablet is used to treat the following:
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Type 2 diabetes mellitus
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Obese individuals with type 2 diabetes
How Dapaglyn S 5mg/50mg Tablet Works
The Dapaglyn S 5mg/50mg Tablet in the treatment of type 2 diabetes provides a dual therapeutic effect by lowering blood glucose levels through different mechanisms: dapagliflozin reduces glucose reabsorption in the kidneys, leading to increased urinary excretion, while sitagliptin enhances insulin secretion and reduces glucagon production. This approach improves glycemic control, reduces the risk of hypoglycemia, and may offer cardiovascular and renal benefits.
How Dapaglyn S 5mg/50mg Tablet Works
The Dapaglyn S 5mg/50mg Tablet in the treatment of type 2 diabetes provides a dual therapeutic effect by lowering blood glucose levels through different mechanisms: dapagliflozin reduces glucose reabsorption in the kidneys, leading to increased urinary excretion, while sitagliptin enhances insulin secretion and reduces glucagon production. This approach improves glycemic control, reduces the risk of hypoglycemia, and may offer cardiovascular and renal benefits.
Interaction of Dapaglyn S 5mg/50mg Tablet with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Dapaglyn S 5mg/50mg Tablet, reducing effectiveness by causing undesirable side effects.
Storage Conditions
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Store at room temperature, between 20°C to 25°C.
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Keep away from moisture, heat, and light.
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It should not be frozen.
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Keep away from children and pets.
How to take Dapaglyn S 5mg/50mg Tablet
Dapaglyn S 5mg/50mg Tablet can be administered orally in tablet form. The specific usage instructions may vary depending on the condition being treated and the form of the medication. Oral tablets are typically taken with water, as directed by the healthcare provider.
Safety Advices
Breast Feeding
The safety of Dapaglyn S 5mg/50mg Tablet during breastfeeding has not been well studied, and limited information is available regarding its excretion into breast milk. As a result, it is recommended to exercise caution when using it while breastfeeding.
Alcohol
Dapaglyn S 5mg/50mg Tablet with alcohol can increase the risk of certain side effects and adverse reactions. It is generally recommended to avoid or limit alcohol consumption while taking these medications.
Liver
If you have a liver impairment or concerns about the safety of using Dapaglyn S 5mg/50mg Tablet, discuss these with your healthcare provider. They can provide personalized guidance and ensure the most appropriate treatment plan for your medical condition.
Lungs
Individuals with pre-existing lung conditions must inform their healthcare provider about their medical history before starting any new medication.
Driving
Dapaglyn S 5mg/50mg Tablet can cause side effects that may impair driving abilities in some individuals. Therefore, caution is advised when operating a vehicle or performing any tasks that require alertness and concentration while taking these medications.
Pregnancy
The safety of Dapaglyn S 5mg/50mg Tablet during pregnancy has not been extensively studied, and limited information is available regarding its use in pregnant women. So it is advisable to consult a healthcare provider before using it.
Side Effects
Dapaglyn S 5mg/50mg Tablet cause some side effects like all medications, although not everyone will experience them.
Serious
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Upper respiratory tract infections (colds, sore throat)
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Headache
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Stomach upset or nausea
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Diarrhea
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Hypoglycemia (low blood sugar)
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Joint pain (arthralgia)
Common
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Genital yeast infections (vaginal or penile)
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Urinary tract infections (UTIs)
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Increased urination
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Thirst
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Dehydration
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Low blood pressure (hypotension)
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Dizziness or lightheadedness
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Increased levels of cholesterol and blood fats (hyperlipidemia)
Expert Tips
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Take Dapaglyn S 5mg/50mg Tablet exactly as prescribed by your doctor for type 2 diabetes.
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Watch for infections in the genital or urinary area, and stay well-hydrated to avoid dehydration.
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Be aware of diabetic ketoacidosis symptoms like nausea, vomiting, or abdominal pain, and seek help if they appear.
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If you have kidney issues or are combining it with other diabetes medications, monitor for side effects carefully.
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Attend follow-up appointments regularly and discuss any concerns with your healthcare provider.
FAQs
Q1.
What should I do if I miss a dose of Dapaglyn S 5mg/50mg Tablet?
If you miss a dose, take it as soon as you remember unless it is close to the time of your next scheduled dose. In that case, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for the missed one. If you are unsure or have questions about missed doses, contact your healthcare provider for guidance.
Q2.
Are there any potential side effects related to the combination of Dapaglyn S 5mg/50mg Tablet?
While Tab Dapaglyn S 5mg/50mg has their own specific side effects, there are no known unique side effects associated with the combination of these medications. However, the risk of certain side effects, such as urinary tract infections or genital infections, may be increased due to the mechanism of action of dapagliflozin.
Q3.
Can Dapaglyn S 5mg/50mg Tablet be used in older adults with type 2 diabetes?
Both Dapaglyn S 5mg/50mg Tablet can be used in older adults with type 2 diabetes; however, individual factors and medical conditions should be considered. Older adults may have different medical needs and risk profiles, so your healthcare provider will assess your overall health and determine the most suitable treatment plan. Regular monitoring and follow-up are particularly important in this population.
Q4.
Can I take Dapaglyn S 5mg/50mg Tablet if I have a history of recurrent urinary tract infections?
It is essential to discuss your medical history with your healthcare provider. While dapagliflozin may increase the risk of urinary tract infections, sitagliptin is not associated with such risk. Your healthcare provider will evaluate the overall benefit-risk profile and may suggest additional preventive measures or alternative medications based on your health status.
Q5.
Can Dapaglyn S 5mg/50mg Tablet be used together with insulin or other antidiabetic medications?
Yes, Dapaglyn S 5mg/50mg Tablet can be combined with other antidiabetic medications, including insulin, to achieve better blood glucose control in individuals with type 2 diabetes. However, adjustments in dosages or monitoring may be necessary to minimize the risk of hypoglycemia (low blood sugar) when using multiple diabetes medications together.
Fact Box
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Molecule name: |
Dapagliflozin + Sitagliptin |
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Therapeutic class: |
Antidiabetic |
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Pharmacological class: |
1. Sodium-glucose cotransporter 2 (SGLT2) inhibitors 2. Dipeptidyl peptidase-4 (DPP-4) inhibitor |
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Indications: |
1. Type 2 diabetes mellitus 2. Obese individuals with type 2 diabetes |
References
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Mohsin Kazi et al., Development and optimization of sitagliptin and dapagliflozin loaded oral self-nanoemulsifying formulation against type 2 diabetes mellitus, [Revised on 28/12/2021] [Accessed on 19/07/2023], https://pubmed.ncbi.nlm.nih.gov/33345632/
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Yue Sun et al., Effects of Dapagliflozin and Sitagliptin on Insulin Resistant and Body Fat Distribution in Newly Diagnosed Type 2 Diabetic Patients [Revised on 26/4/2020] [Accessed on 19/07/2023], https://pubmed.ncbi.nlm.nih.gov/32240122/
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details

Written By
P. Thirumal Reddy
B. Pharm

Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 03 Oct 2026 | 08:57 AM (IST)

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