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Duovir E Kit Tablet
Prescription Required
Salt Composition : Efavirenz,lamivudine,zidovudine
Manufacturer : CIPLA LTD
Origin of Medicine : India
1 Tablet(s) In A Strip
Introduction to Duovir E Kit Tablet
Duovir E Kit Tablet contains the active ingredient Efavirenz + Lamivudine + Zidovudine. It is a combination of three antiretroviral medicines. Lamivudine, Zidovudine belong to the class of medications called nucleoside/nucleotide reverse transcriptase inhibitors. Efavirenz belongs to the class of medication called non-nucleoside reverse transcriptase inhibitors. It is used to treat HIV-1 infection. It mainly occurs when a person's immune system is attacked and weakened by the human immunodeficiency virus (HIV). This infection progressively weakens the immune system, making individuals more susceptible to opportunistic infections.
This drug is contraindicated in individuals with severe renal impairment and may have altered drug clearance, which mainly affects the efficacy and safety of the medicine. Also, it is highly advised not to use this drug in patients with severe renal impairment. Dose adjustment is necessary for such conditions. Tell your doctor if you have any liver disease, including hepatitis B or C, kidney disease, heart problems, diabetes, history of seizures, mental health problems, consumed street drugs, or large amounts of alcohol before taking Duovir E Kit Tablet. The administration of this medicine is associated with hematologic toxicity (decrease in blood cells), muscle weakness, liver diseases, infection, and lactic acidosis (acid buildup due to problems in the body's metabolism). Do not breastfeed. Consult your doctor about safe sex practices.
During the initial stage of treatment, some patients may experience an inflammatory response to opportunistic infections. This condition, immune reconstitution syndrome, can occur after starting the drug or other antiretroviral therapies. Knowing this possibility and monitoring for any signs of worsening infections or inflammatory symptoms is necessary. Inform your healthcare provider if the symptoms concern you or persist longer than usual. Patients are also advised to report any skin or hypersensitivity reactions to their healthcare provider and to seek medical emergency immediately if they experience any symptoms of a severe reaction. Tell your doctor immediately about all the medications you have been taking recently, including herbal and supplements, before taking Duovir E Kit Tablet.
Uses of Duovir E Kit Tablet
- HIV-1 Infection
Therapeutic Effects of Duovir E Kit Tablet
Duovir E Kit Tablet is a combination of three antiretroviral medicines. It works by inhibiting the enzyme reverse transcriptase, thereby inhibiting the replication of viral particles in the body and treating the infection.
Interaction of Duovir E Kit Tablet with other drugs
Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, supplements, and herbal products. Certain medications, including Trimethoprim/sulfamethoxazole, zalcitabine, Co-administration of ganciclovir, interferon-alpha, and stavudine, may interact with Duovir E Kit Tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Duovir E Kit Tablet
- Store Duovir E Kit Tablet at (20°C to 25°C).
- Keep the medicine out of reach of children and pets.
How to consume Duovir E Kit Tablet
Take the Duovir E Kit Tablet as advised by your physician. Swallow the tablets whole and intact. This tablet should be taken with food. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the medicine if your doctor advises you to stop.
Safety Advices for Duovir E Kit Tablet
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Pregnancy
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Duovir E Kit Tablet may cause harm to an unborn baby. Inform your doctor if you are pregnant or planning to get pregnant before taking this tablet. The doctor will explain the potential risks and benefits.
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Breast Feeding
 ÂBreastfeeding is not recommended in patients taking Duovir E Kit Tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.Â
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Lungs
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It is unknown whether Duovir E Kit Tablet is safe for lung disease patients. Inform your physician if you have any lung diseases before initiating the therapy.
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Liver
  Duovir E Kit Tablet should be cautiously used in patients with liver diseases. Dose adjustments are necessary. However, inform your physician of any liver diseases before initiating the therapy.
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Alcohol
 ÂIt is unsafe to consume alcohol while taking the Duovir E Kit Tablet. It may reduce the drug's effectiveness and can cause toxic side effects.
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Driving
  Avoid driving if you feel unwell, as Duovir E Kit Tablet may make you feel dizzy and less alert.
Side Effects of Duovir E Kit Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Lactic acidosis (breathing difficulties along with weakness in limbs, stomach pain, and drowsiness)
- Liver problems (yellowing of skin or eyes, tea-colored urine, light-colored stools, abdominal pain)
- Nervous system symptoms (trouble-concentrating, sleeping, unusual dreams, lack of coordination)
- Hypersensitive reactions
- Seizures
- Changes in body fat
- Muscle pain or weakness
- Blood problems (low number of white blood cells)
Common
- Nausea, vomiting
- Headache, dizziness
- Tiredness
- Fever or chills
- Diarrhea
- Cough
- Decreased appetite
Word of Advice
Do not share personal objects such as toothbrushes or razors with anyone. To prevent the spread of HIV infection, avoid sharing needles or syringes, which can transmit the infection easily. It's necessary for individuals who use injectable drugs to use sterile needles and syringes and never share them with others. Personal items should also be avoided. They should not be shared because HIV-1 can be present in blood and certain body fluids, and sharing these items could mainly transmit the virus.
Since this drug is unsafe for breastfeeding because HIV infection can be passed to the baby in the breast milk, alternative feeding methods can be followed to nourish the infant's growth. If you forget to take Duovir E Kit Tablet for the entire day, take your usual dose the next day. However, do not double-dose yourself. Throw away medicines that are no longer needed or are out-of-date. Keep medicines away from children and pets. Do not store these medicines in a damp place such as a bathroom, cabinet, or near the kitchen sink.
FAQs
Q 1. What happens if I miss a dose of Duovir E Kit Tablet?
Do not miss any doses of Duovir E Kit Tablet. If you forget to take these medications, take them immediately. If it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not double the next dose.
Q 2. What should I tell my doctor before taking the Duovir E Kit Tablet?
If you have previously taken medications for HIV treatment, inform your doctor to ensure appropriate adjustment of your treatment regimen before taking Duovir E Kit Tablet.
Q 3. Can I give a Duovir E Kit Tablet to others if they have the same symptoms as me?
Do not use Duovir E Kit Tablet for a condition that was not prescribed. Do not give these medications to others, even if they have the same condition you have. It may harm them.
Q 4. Does Duovir E Kit Tablet reduce the risk of passing HIV to others?
Yes, Duovir E Kit Tablet, when used as part of an effective antiretroviral therapy (ART) regimen, can reduce the risk of passing HIV to others. This combination of medications is commonly used to treat HIV infection and is known as a highly active antiretroviral therapy (HAART).
Q 5. How does Duovir E Kit Tablet work?
When used together, the combination of Duovir E Kit Tablet may help in lowering the amount of HIV in your blood (called "viral load") and increase your CD4 (T) cell count. HIV infection destroys CD4 (T) cells, which are important to the immune system. The immune system helps fight infection. Reducing the amount of HIV and increasing the CD4 (T) cell count may improve your immune system. It may reduce the risk of death or infections when your immune system is weak.
Fact Box of Duovir E Kit Tablet
Molecule name: Efavirenz + Lamivudine + Zidovudine | Therapeutic class: Antiretroviral |
Pharmacological class: Lamivudine + Zidovudine - Nucleoside reverse transcriptase inhibitor Efavirenz - Non-nucleoside reverse transcriptase inhibitor | Indications: HIV-1 infection |
References
- Strides Arcolab Limited, US Food and Drug Administration, [ Issued on May 2007] [ Accessed on 19th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/pepfar/022096PI.pdf
- Cipla Ltd, [ Revised on July 2020] [ Accessed on 19th May 2023], https://www.ciplamed.com/content/duovir-e-kit
- KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 806 - 811.
- Goodman & Gilman's, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1632-1634.
Disclaimer
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