The uses of Endokine 300mcg Injection PFS are:

• To prevent infections after chemotherapy due to decreased white blood cells (neutropenia)

Endokine 300mcg Injection PFS is a colony-stimulating factor that acts on blood-forming cells by binding to specific cell surface receptors, thereby inducing cell division, multiplication, and cell functional activation. 

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Endokine 300mcg Injection PFS and reduce effectiveness by causing undesirable side effects. 

• Store Endokine 300mcg Injection PFS in a refrigerator (2°C – 8°C). Do not freeze.
• Do not shake the pre-filled syringe.
• Discard the medicine if stored at room temperature for more than 48 hours.
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor immediately for advice.

Endokine 300mcg Injection PFS is available as a prefilled syringe and solution for injection. A qualified healthcare professional will administer the injection slowly in the fatty tissues just under your skin (subcutaneously), or it will be administered slowly as an intravenous injection into your vein. The dose, route of administration, and frequency will be decided by your doctor based on your disease condition and other factors. 

If your physician decides that you or your caregiver can administer the Endokine 300mcg Injection PFS prefilled syringe at home, then read the “Instructions for use” carefully from the package insert with the medicine. 

Your doctor or other healthcare professionals will train you on self-administration. Do not administer the medicine if you have not been trained and are not sure about the administration procedure. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common side effects of Endokine 300mcg Injection PFS are:

• Pain in the bones, joints, and muscles
• Pain at the site of Injection
• Fever
• Itchiness and skin rash
• Nausea
• Headaches
• Dizziness and tiredness
• Nose bleeding
• Hair fall

Serious side effects of Endokine 300mcg Injection PFS are:

• Inflammation of Aorta
• Capillary leak syndrome (plasma leaks out of tiny blood vessels)
• Hypersensitivity reactions
• Changes in urine colour
• Swelling in hands, feet, face, and abdomen
• Difficulty in breathing
• Sickle cell anemia

Inform your physician if you are experiencing any symptoms of swelling in the face, feet, hands, and abdomen, difficulty in breathing, sudden drop in blood pressure, left abdominal pain, weakness, and skin rashes. If you use the prefilled syringe, allow the medicine to warm for 30 minutes at room temperature before injecting. Read the package insert carefully if you are self-administering the medicine. This medicine may cause lung, liver, or kidney problems. Your physician may advise you to take laboratory tests regularly to monitor the effectiveness of the therapy.

1. Neupogen Singleject 30 MU (0.6 mg/ml) - Patient Information Leaflet (PIL) - (emc) ww.medicines.org.uk. [Revised on 2022] [cited 2023 Mar 14]. Available from: https://www.medicines.org.uk/emc/product/608/pil
2. Neupogen 30 MU (0.3 mg/ml) solution for injection - Patient Information Leaflet (PIL) - (emc). www.medicines.org.uk. [Revised on 2022] [cited 2023 Mar 14]. Available from: https://www.medicines.org.uk/emc/product/3000/pil
3. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs, 7th edition, 2013, 876