• Prostate cancer resistant to other treatments
• Metastatic prostate cancer reacts to hormone therapy or surgery to reduce testosterone levels
• Non metastatic prostate cancer with a high chance of spread and recurrence.

Enzalieva 40mg Capsule medicine acts by blocking the activity of androgens hormone (such as testosterone) by binding with androgen receptors. Enzalieva 40mg Capsule prevents the Androgen receptor from moving to its new site, which further lowers AR-mediated transcriptional activity and stops the growth of tumor cells. Enzalieva 40mg Capsule inhibits the AR complex's ability to bind to DNA, which stops the transcriptional activation of AR target genes. As a result, it reduces testosterone levels and halts the growth and division of prostate cancer cells.

Interaction with other drugs:

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Enzalieva 40mg Capsule and reduce effectiveness by causing undesirable side effects. 

• Enzalieva 40mg Capsule should be stored at room temperature between 20°C and 25°C (68°F and 77°F).
• It should be kept dry and protected from light and moisture.
• The capsules should be kept in the original container with the cap tightly closed..
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

Enzalieva 40mg Capsule is usually taken orally, with or without food. The capsules should be swallowed whole with a glass of water and not crushed, chewed or broken.

The dosage and frequency of Enzalieva 40mg Capsule will depend on various factors, including the patient's age, weight, overall health, and the type and stage of cancer being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first. Pregnant or potentially pregnant women shouldn't handle broken or damaged Xtandi tablets without wearing gloves or other protective gear.

If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It's important not to take a double dose of abemaciclib to make up for a missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

• Tiredness
• Fall
• Hot flushes
• High blood pressure
• Headache
• Feeling anxious
• Dry skin
• Itching
• Difficult in remembering
• Restlessness

Serious: 

• Posterior Reversible Encephalopathy Syndrome (PRES)
• Blockage of the arteries (ischemic heart disease)
• Enlargement of breast in men (gynaecomastia)
• Broken bones

If you have prescribed Enzalieva 40mg Capsule, it is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly.  It is advised not to consume grape juice during the treatment. Stay hydrated by consuming lots of liquids, particularly if you get diarrhea when using Enzalieva 40mg Capsule. It's critical to maintain a sufficient fluid intake because dehydration can exacerbate symptoms such as diarrhea and other gastrointestinal disorders. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping Enzalieva 40mg Capsule. It is recommended to monitor your blood counts and bone density at regular intervals. It is not advised for women, particularly for those who are nursing or pregnant. Notify your physician if you experience frequent urges to urinate, blood in your urine, or digestive issues. Inquire with your physician if you get discomfort in the bladder or colon, as the medication may result in bladder or colon cancer as a side effect.

Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately. With proper monitoring and management, Enzalieva 40mg Capsule can be an effective treatment option for prostate cancer.

1. Astellas Pharma Europe B.V, Electronics Medicines Compendium(emc), [ Revised on December 2022] [ Accessed on 30/03/2024], https://www.medicines.org.uk/emc/files/pil.10318.pdf
2. Astellas Pharma US Inc,  United States Food and Drug Administration (US FDA), [ Revised on January 2022] [ Accessed on 30/03/2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/203415s018,213674s005lbl.pdf
3. Astellas Pharma US, Inc, [Revised on November 2023], [Accessed on 30/03/2024],  https://www.astellas.us/docs/12A005-ENZ-WPI.PDF
4. KD Tripathi, Essentials of Medical Pharmacology, Adrenergic system and drugs, 7th edition, 2013, 134.