Fonaxel 2.5mg Injection

Introduction:

Fonaxel 2.5mg Injection consists of the active ingredient Fondaparinux Sodium. It is indicated for the prevention and treatment of venous thromboembolism after surgery. Venous thromboembolism is the leading cause of preventable death among patients undergoing surgical procedures. This condition occurs due to altered blood flow, injury and variation in the composition of blood.

This medicine is also prescribed to prevent and treat blood clot formation in acutely ill patients who are deprived of movement. It also treats heart attacks and chest pain due to narrow blood vessels (angina).

Uses of Fonaxel 2.5mg Injection:

• Prevention and treatment of venous thromboembolism
• Treatment of heart attack and severe angina
• Treatment of blood clots on the surface of the skin of the legs
• Prevention of blood clot formation in acutely ill patients devoid of mobility

How Fonaxel 2.5mg Injection works:

Fondaparinux Injection binds to the antithrombin protein and enhances the inactivation of factor Xa. This interrupts the blood clotting cascade and inhibits thrombin formation and clot development. As a result, unwanted blood clots do not develop in the blood vessels.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Store at a temperature below 25˚C. Do not freeze.

References:

1. GlaxoSmithKline Pharmaceuticals Limited, [Revised on 6th Nov 2015] [Accessed on 13th Jul 2021], https://india-pharma.gsk.com/media/701015/arixtra.pdf
2. Dr. Reddy’s Laboratories (UK) Ltd, Electronic Medicines Compendium (EMC), [Revised on Jul 2019] [Accessed on 13th Jul 2021], https://www.medicines.org.uk/emc/files/pil.9756.pdf
3. James L. Zehnder, Drugs Used in Disorders of Coagulation, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 608-625.
4. Kumar et al., Fondaparinux Sodium Compared With Low-Molecular-Weight Heparins for Perioperative Surgical Thromboprophylaxis: A Systematic Review and Meta-analysis, Journal of the American Heart Association, 2019, https://pdfs.semanticscholar.org/79e3/238225d5e7a5c08ea60f3c2d5aa5877bae0e.pdf?_ga=2.48382756.368595277.1626168591-44692483.1618326608

How to use Fonaxel 2.5mg Injection:

For subcutaneous/intravenous use only. Use as directed by the physician.

Safety Advice:

Pregnancy:

Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will prescribe this medicine only if the benefits are more than risks.

Breastfeeding: 

Consult your physician for advice before breastfeeding during this treatment. Your physician might recommend stopping breastfeeding during this treatment.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Use with caution if you have severe liver impairment.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. Your physician will alter the dose according to your condition.

Allergies: 

Inform your physician if you experience allergic reactions to latex, Fondaparinux Sodium or its ingredients.

Others:

• Inform your physician if you are older than 75 years of age or weigh less than 50kg.
• Inform your physician before starting this treatment if you have recently undergone surgery on the brain, spine or eye.
• Inform your physician before starting this treatment if you have bleeding disorders or stomach ulcers.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Severe allergic reactions

Common:

• Bleeding
• Anaemia