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Grandem Syrup
Prescription Required
Salt Composition : Granisetron
Manufacturer : ARISTO PHARMACEUTICALS PVT LTD
Origin of Medicine : India
1 Bottle(s) Of 10ml
Introduction to Grandem Syrup
Grandem Syrup belongs to the group of medicines known as 5-HT3 receptor antagonists or antiemetics. It contains the active ingredient, Granisetron. It is used to prevent and treat nausea, vomiting, or sickness caused by cancer treatments such as chemotherapy, radiotherapy, or after surgery. Nausea is characterised by stomach pain and the urge to vomit. The forcible, voluntary or involuntary emptying of the stomach's contents through the mouth is known as vomiting.
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Uses of Grandem Syrup
The Grandem Syrup uses are to:
- Prevent or treat nausea and vomiting during cancer treatment.
Therapeutic Effects of Grandem Syrup
Grandem Syrup works by blocking the action of serotonin (chemical messenger) in the brain, which is responsible for nausea and vomiting during cancer treatment like chemotherapy and radiation therapy or after surgery.
Interaction of Grandem Syrup with other drugs
Grandem Syrup, which contains granisetron as its active ingredient, may interact with other medications, potentially affecting its effectiveness or increasing the risk of side effects. Caution should be exercised when taken with other serotonergic drugs such as SSRIs, SNRIs, or MAO inhibitors, as this may increase the risk of serotonin syndrome—a rare but serious condition. Additionally, combining Grandem Syrup with medications that affect heart rhythm, such as certain antiarrhythmics or antipsychotics, may increase the risk of QT prolongation. Always inform your healthcare provider about all the medications, supplements, or herbal products you are taking to avoid harmful interactions.
More Information about Grandem Syrup
- Keep this medicine out of sight and out of reach of children.
- Do not use it after the expiration date.
How to consume Grandem Syrup
Grandem Syrup is administered into the vein by a nurse or doctor. Your physician will decide on the grandem syrup dosage and duration depending on the severity of your medical condition. Grandem syrup dosage for infants is always decided by the paediatrician. Remember that Grandem Syrup is for paediatric use only.
Safety Advices for Grandem Syrup
Pregnancy
Grandem Syrup is not safe to be used during pregnancy. Consult with your doctor for advice.
Breast Feeding
Grandem Syrup is used with caution in breastfeeding women as it is unknown if it passes into breast milk. Consult with your physician for advice.
Lungs
Inform your physician before consuming syp grandem if you have lung disease.
Liver
Inform your physician before starting this treatment if you have liver disease.
Alcohol
It is unknown whether it is safe to consume alcohol with Grandem Syrup. Consult your doctor for advice.
Driving
Grandem Syrup usually does not affect your ability to drive and operate heavy machines. Avoid driving or using machinery if you experience side effects.
Side Effects of Grandem Syrup
Side effects are unwanted symptoms caused by medicines. Although all medicines cause side effects, not everyone gets them.
Severe side effects of Grandem Syrup are:
- Allergic reaction (anaphylaxis)
- Skin rashes
- Abnormal involuntary movements, such as shaking
- Muscle rigidity and contractions
- Changes in the heartbeat and ECG readings
Common side effects of Grandem Syrup are:
- Headache
- Constipation
- Diarrhea
- Insomnia (difficulty in sleeping)
- Changes in liver function tests
Word of Advice
Inform your healthcare provider while taking Grandem Syrup if you are undergoing any medical tests. It is advised to monitor your heart function with an ECG (electrocardiogram) since this medication may cause irregular heartbeat. It is not given to children to treat sickness after surgery. Eat high-fiber foods in your diet and drink more water to stay hydrated.
FAQs
Q 1. What is Grandem Syrup used for?
Grandem Syrup is used to prevent or treat nausea and vomiting during cancer treatment, like radiotherapy, chemotherapy, or after surgery.
Q 2. Does Grandem Syrup cause constipation?
Yes, Grandem Syrup can cause constipation, which is one of the side effects of this medication. You can avoid it by eating high-fiber foods in your diet.
Q 3. Can I drive after taking Grandem Syrup?
Yes, Grandem Syrup does not affect the ability to drive and operate heavy machines. If you experience any side effects, then avoid driving or operating any machine.
Q 4. What class of medication is Grandem Syrup?
Grandem Syrup belongs to the class of medications known as 5-HT3 receptor antagonists or antiemetics.
Q 5. Who is contraindicated to taking Grandem Syrup?
Patients who have experienced allergic reactions (hypersensitivity), bowel movement problems, heart problems, and pregnant and breastfeeding women should not use Granisetron.
Fact Box of Grandem Syrup
Molecule name: Granisetron
| Therapeutic class: 5-HT3 receptor antagonists |
| Pharmacological class: Antiemetics | Indications: Prevent or treat nausea and vomiting |
References
1. Hameln Pharma, Electronic Medicines Compendium (EMC), [Revised on Apr 2020] [Accessed on 22 November 2022], https://www.medicines.org.uk/emc/files/pil.6423.pdf
2. Roche Laboratories Inc., US Food and Drug Administration, [ Revised on Sep 2009] [ Accessed on 22 November 2022], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/20334s007s008lbl.pdf
3. GL Plosker et al; Granisetron: A review of its pharmacological properties and therapeutic use as an antiemetic; Published on 1991, Accessed on 22/09/2022, https://pubmed.ncbi.nlm.nih.gov/1723376/
4. Matti Apro; Granisetron: an update on its clinical use in the management of nausea and vomiting; Published on 2004, Accessed on 22/9/2022, https://pubmed.ncbi.nlm.nih.gov/15561811/
Disclaimer
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