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Hepaglan 25000IU Injection
Last updated on 16 Jul 2026 | 04:47 AM (IST)
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Introduction to Hepaglan 25000IU Injection
Hepaglan 25000IU Injection contains an active component such as Heparin. It is a widely used anticoagulant medication, meaning it prevents the formation of blood clots. It is commonly prescribed in various medical situations to reduce the risk of clotting, especially in patients who are at higher risk for developing blood clots. Hepaglan 25000IU Injection is commonly used in hospitals to prevent and treat deep vein thrombosis (DVT), pulmonary embolism (PE), and other conditions where the formation of blood clots is a concern. It is also used during certain surgical procedures and in dialysis to prevent clotting in the extracorporeal circuit. The effect varies among individuals, so its administration requires careful monitoring of blood clotting parameters, usually through the activated partial thromboplastin time (aPTT) test. The dosage may need to be adjusted to maintain therapeutic levels. In case of excessive bleeding or an overdose of Hepaglan 25000IU Injection, its effects can be reversed using protamine sulfate, an antidote for this medication.
Patients with known hypersensitivity or allergic reactions should not use Hepaglan 25000IU Injection. While this medication is generally safe, it may not suit people with certain medical conditions, such as bleeding disorders or recent major surgeries. You must inform your healthcare provider about any existing medical conditions and medications you are taking before starting the therapy. Elderly individuals may be more susceptible to bleeding complications, and lower dosages or closer monitoring may be necessary. Impaired liver or kidney function can affect the metabolism and elimination of this medication, potentially leading to adverse effects. Dosing adjustments may be necessary for patients with these conditions.
Uses of Hepaglan 25000IU Injection
Hepaglan 25000IU Injection is used to treat the following:
- Deep vein thrombosis
- Pulmonary embolism
- Disseminated intravascular coagulation
- Venous thromboembolism prophylaxis
- Atrial fibrillation with a high risk of stroke
- Hemodialysis
- Pregnancy-related thrombosis
Therapeutic Effects of Hepaglan 25000IU Injection
Hepaglan 25000IU Injection enhances the activity of antithrombin III, a natural anticoagulant protein in the body. By binding to antithrombin III, this medication accelerates its inhibitory effect on clotting factors, particularly thrombin and factor Xa. This inhibition disrupts the blood coagulation cascade, preventing fibrin formation, an essential component of blood clots. As a result, this medication effectively reduces the risk of clot formation and growth, making it a valuable anticoagulant used in various medical conditions.
Interaction of Hepaglan 25000IU Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Hepaglan 25000IU Injection, reducing effectiveness by causing undesirable side effects.
More Information about Hepaglan 25000IU Injection
- Store at room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Hepaglan 25000IU Injection
Hepaglan 25000IU Injection is typically administered by injection either intravenously (IV) or subcutaneously (under the skin). The specific dosage and administration method depends on the medical condition being treated, the patient's weight, age, and other factors, which a healthcare professional should determine. For IV use, this medication is usually given in a hospital setting under continuous monitoring to adjust the dosage as needed. Subcutaneous injections are often used for prophylactic purposes or in outpatient settings.
Safety Advice for Hepaglan 25000IU Injection
Breast Feeding
While Hepaglan 25000IU Injection is considered safe during breastfeeding, as with any medication, nursing mothers need to discuss their specific situation with a healthcare provider.
Alcohol
Hepaglan 25000IU Injection may affected by alcohol consumption. It's essential to consult with a healthcare professional about the suitability of alcohol consumption based on individual health conditions and the specific regimen.
Liver
Hepaglan 25000IU Injection is considered relatively safe for patients with liver impairment. Unlike other anticoagulant medications, this medication is not metabolized by the liver, and its elimination primarily occurs through the kidneys.
Lungs
Hepaglan 25000IU Injection is generally safe for the lungs, as it is an anticoagulant primarily used to prevent and treat blood clots in the circulatory system, not the lungs directly. It is often used to treat conditions like pulmonary embolism (PE), where blood clots block blood flow to the lungs.
Driving
Hepaglan 25000IU Injection does not directly affect a person's driving ability, as it is not known to cause drowsiness or impair cognitive and motor skills. Therefore, taking it, as prescribed will not likely interfere with one's ability to drive safely.
Pregnancy
Hepaglan 25000IU Injection is generally considered safe to use during pregnancy, and it is often preferred over certain other anticoagulants, especially vitamin K antagonists like warfarin. This preference is due to its minimal placental transfer, which means it does not cross the placenta to a significant extent and has a lower risk of harming the developing fetus.
Side Effects of Hepaglan 25000IU Injection
Hepaglan 25000IU Injection causes some side effects like all medications, although not everyone will experience them.
Serious:
- Severe allergic reactions, including rash, itching, swelling, severe dizziness, or difficulty breathing
- Bleeding
- Hepaglan 25000IU Injection-induced thrombocytopenia (HIT)
- Osteoporosis (bone weakness)
Common:
- Bruising
- Hematomas
- Pain at Injection Site
- Redness at Injection Site
- Elevated Liver Enzymes
- Fever
- Nausea
- Vomiting
Word of Advice
Patients should inform their healthcare providers about their medical history, including any bleeding disorders, liver or kidney problems, recent surgeries, and allergies, to determine the appropriate dosage and administration method. Regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay, is crucial to maintain the desired anticoagulant effect and prevent bleeding or thrombosis. Patients should follow the prescribed dosage and administration instructions precisely and report any unusual bleeding, bruising, or allergic reactions promptly. It is advisable to avoid activities or medications that may increase the risk of bleeding while on Hepaglan 25000IU Injection. By adhering to these instructions and maintaining open communication with healthcare providers, patients can minimize risks and maximize the benefits of this therapy.
FAQs about Hepaglan 25000IU Injection
Q1.
What are the side effects of Hepaglan 25000IU Injection?
Common side effects of Hepaglan 25000IU Injection may include bruising, hematomas, pain at the injection site, and elevated liver enzymes. Serious side effects can include bleeding, Heparin-induced thrombocytopenia (HIT), hypersensitivity reactions, and osteoporosis.
Q2.
Can I take Hepaglan 25000IU Injection if I am pregnant or breastfeeding?
Hepaglan 25000IU Injection is generally considered safe during pregnancy and breastfeeding. It does not cross the placenta significantly and is not expected to harm the baby when used appropriately. However, its use should be under the guidance of a healthcare provider.
Q3.
How is Hepaglan 25000IU Injection dosed?
Hepaglan 25000IU Injection dosing varies based on the patient's weight, medical condition, and desired anticoagulant effect. The dosage is usually adjusted based on regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay.
Q4.
Is there a risk of bleeding with Hepaglan 25000IU Injection?
Yes, Hepaglan 25000IU Injection increases the risk of bleeding. Patients should be closely monitored for signs of bleeding and inform their healthcare provider promptly if they experience any unusual bleeding or bruising.
Q5.
Can Hepaglan 25000IU Injection be used in children and the elderly?
Hepaglan 25000IU Injection can be used in children and the elderly. However, special consideration is required in these populations due to differences in dosing and potential age-related factors that may affect its use.
Fact Box of Hepaglan 25000IU Injection
Molecule name: Heparin | Therapeutic class: Anticoagulants |
Pharmacological class: Anticoagulants
| Indications: 1. Deep vein thrombosis 2. Pulmonary embolism 3. Disseminated intravascular coagulation 4. Venous thromboembolism prophylaxis 5. Atrial fibrillation with a high risk of stroke 6. Hemodialysis 7. Pregnancy-related thrombosis |
References
- Wockhardt UK Ltd, Electronic medicines compendium (EMC), [Revised on June 2018] [ Accessed on 30th July 2023], https://www.medicines.org.uk/emc/files/pil.1678.pdf
- Baxter Healthcare Corporation, US Food, and Drug Administration, [Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017037s158lbl.pdf
- KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding, and thrombosis, 7th edition, 2013, 617
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 16 Jul 2026 | 04:47 AM (IST)
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