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HOLOXAN WITH UROMITEXAN 2GM INJECTION
Prescription Required
Salt Composition : Ifosfamide,mesna
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
1 Vial(s) Of (1x2g),(6x2ml)
Introduction to Holoxan With Uromitexan 2gm Injection
Holoxan with uromitexan 2gm injection is an anticancer and cytoprotective drug belonging to the category of alkylating agents and hemorrhagic cystitis inhibitors, containing the active ingredient Ifosfamide and Mesna. These drugs are indicated for the treatment of bladder inflammation and cancers in the soft tissues, germ cells, pancreas, and cervix. Mesna mainly protects against some of the harmful effects of certain chemotherapy medications.Â
If you had an allergic reaction to this drug or any of its components, it should not be used. This medicine may cause severe bone marrow suppression which results in low white blood cell count or low platelet count due to chemotherapy or radiation therapy. You should wait for three months before starting the treatment with this drug if you have received a live virus vaccine such as measles, mumps, rubella, or chickenpox. It is advised to use this drug with caution in severe kidney or liver-diseased individuals. Talk to your doctor if you take any other medications or before using over-the-counter medicines or herbal products. Your doctor will evaluate the risk of interaction with this medication.
Consult your doctor before using this medication if you are pregnant or plan to have a baby. Holoxan with uromitexan 2gm injection is unsafe to use during pregnancy as it causes harm to an unborn fetus. Your healthcare practitioner will conduct a pregnancy test before you start treatment with this drug. Discuss with your doctor effective birth control methods and utilize them for at least two weeks following the last dose. Breastfeeding should be avoided during the treatment with this drug as it may pass into breast milk in small amounts.
Uses of Holoxan With Uromitexan 2gm Injection
- Hemorrhagic cystitis (bladder inflammation)
- Soft tissue cancer
- Germ cell cancer
- Pancreatic cancer
- Cervical cancer
Therapeutic Effects of Holoxan With Uromitexan 2gm Injection
These two combinations together work by damaging the DNA in cancer cells, which leads to cell death and slows the growth and spread of cancer. Mostly, this involves the formation of reactive metabolites in the liver, which are then transported to cancer cells in the body. These metabolites react with the DNA in the cancer cells, causing cross-links and breaks in the DNA strands. This interferes with the replication and transcription of DNA, leading to cell death.
Interaction of Holoxan With Uromitexan 2gm Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Holoxan with uromitexan 2gm injection and reduce effectiveness by causing undesirable side effects.Â
More Information about Holoxan With Uromitexan 2gm Injection
- Store Holoxan with uromitexan 2gm injection in a refrigerator (20°C to 25°C).
- Do not freeze.
- Keep it out of reach from children.
How to consume Holoxan With Uromitexan 2gm Injection
It will be given to you by a doctor or nurse in a hospital or clinic setting trained in cancer chemotherapy. Holoxan with uromitexan 2gm injection is given as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Safety Advices for Holoxan With Uromitexan 2gm Injection
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Pregnancy
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Holoxan with uromitexan 2gm injection is unsafe for pregnant women as it may harm the unborn baby. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
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Breast Feeding
 ÂHoloxan with uromitexan 2gm injection is not recommended in breastfeeding women as it may pass into the breast milk.
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Lungs
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It is unknown whether Holoxan with uromitexan 2gm injection can be used for patients with lung problems. Consult your doctor if you have any lung diseases before starting the treatment.
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Liver
  It is unknown whether Holoxan with uromitexan 2gm injection can be used for patients with liver disorders. Consult your doctor if you have any liver diseases before starting the treatment.
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Alcohol
 ÂIt is unknown whether consuming alcohol interacts with the Holoxan with uromitexan 2gm injection. Please consult your doctor for more advice.
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Driving
  It is unsafe to drive vehicles or operate heavy machinery after taking the Holoxan with uromitexan 2gm injection.
Side Effects of Holoxan With Uromitexan 2gm Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Immune system suppression
- Low levels of RBC, WBC, and platelets in the blood
- Bone marrow suppression
- Nerve toxicity
- Urinary problems
- Lung problems
- Kidney problem
- Rash
- Hypersensitivity reactions
Common
- Hair loss
- Fever
- Phlebitis
- Liver toxicity
- Infections
Word of Advice
This injection may cause severe birth defects if taken during pregnancy. Female patients with reproductive potential should use effective contraception during the treatment. Male patients with female partners with reproductive potential should use effective birth control methods during the treatment and for at least 5 months after their last dose. Do not breastfeed during treatment with this injection. Your doctor may advise you to take certain tests to check for the effectiveness of the therapy. Holoxan with uromitexan 2gm injection may cause dizziness, drowsiness, or blurred vision, so it is important to avoid driving. It's important to avoid consuming grapefruit or grapefruit juice while taking this injection because this can lead to increased levels of the drug in your body and a higher risk of side effects. If you miss a dose of this drug and it is close to the time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. It is not recommended to take a double dose to make up for a missed one.
FAQs
Q 1. How is Holoxan with uromitexan 2gm injection administered?
Holoxan with uromitexan 2gm injection is usually administered as an intravenous infusion drip (into your vein). Do not self-administer the injection. Your doctor will decide the dose and duration of the treatment based on your disease severity, body weight, and other factors.
Q 2. What happens if I miss my Holoxan with uromitexan 2gm injection?
If you miss a dose of Holoxan with uromitexan 2gm injection and it is close to the time for your next scheduled dose, you should skip the missed dose and continue with your regular dosing schedule. It is not recommended to take a double dose to make up for a missed one.
Q 3. What is the purpose of Holoxan with uromitexan 2gm injection?
Holoxan with uromitexan 2gm injection is often used in combination with other chemotherapy drugs to increase its effectiveness. It may also be used before surgery to shrink the tumour or after surgery to kill any remaining cancer cells.
Q 4. Whether Holoxan with uromitexan 2gm injection can be given during pregnancy?
No, Holoxan with uromitexan 2gm injection can cause harm to a developing fetus and should not be given during pregnancy.
Q 5. Who should not use Holoxan with uromitexan 2gm injection?
Holoxan with uromitexan 2gm injection is not recommended for people who are allergic to this drug, or any of its ingredients. Also, women who are pregnant or breastfeeding should avoid taking it, because this medicine can harm an unborn baby or pass into breast milk.
Q 6. What should I avoid while taking Holoxan with uromitexan 2gm injection?
It is recommended to quit smoking or limit tobacco use while taking this medication. Smoking may also worsen some of the side effects of Holoxan with uromitexan 2gm injection such as the risk of liver toxicity.
Fact Box of Holoxan With Uromitexan 2gm Injection
Molecule name: Ifosfamide+Mesna | Therapeutic class: Anticancer+Cytoprotectants |
Pharmacological class:Â 1.Ifosfamide-Alkylating agents 2.Mesna-Hemorrhagic cystitis inhibitor | Indications:Â 1.Hemorrhagic cystitis (bladder inflammation) 2.Soft tissue cancer 3.Germ cell cancer 4.Pancreatic cancer 5.Cervical cancer |
References
- Baxter Corporation, [Revised on 27th Jun 2018] [Accessed on 10th Aug 2021], https://www.baxter.ca/sites/g/files/ebysai1431/files/2018-11/Ifex_EN.pdf
- Teva Parenteral Medicines, Inc., [Revised on Feb 2020] [Accessed on 17th Dec 2021], https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=14f535d7-4593-4cee-94fb-54ee239d95d2&type=display
- Boehringer-Ingelheim, Mesna [Revised on March 2014] [ Accessed on 06 April 2023], https://docs.boehringer-ingelheim.com/Prescribing%20Information/PIs/Ben%20Venue_Bedford%20Labs/55390-045-01%20MSN%201G/5539004501
- Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976
- Bertram.G.Katzung, Basic and Clinical Pharmacology, Cancer Chemotherapy, 14th edition, 2017, 953.
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