• HIV infection

Abacavir inhibits the activity of HIV-1 reverse transcriptase (RT) by competing with the natural substrate dGTP and its incorporation into viral DNA. Dolutegravir inhibits HIV integrase by binding to the integrase active site and blocking the strand transfer step of retroviral DNA integration, which is essential for the HIV replication cycle. 

In combination, they work by decreasing the amount of HIV in your blood and increasing the number of immune cells that help fight infections in your body. Although Inbec tablet will not cure HIV, these medications may decrease your chance of developing acquired immunodeficiency syndrome (AIDS) and HIV-related illnesses such as serious infections or cancer.

Inform your healthcare provider about all your medicines, including prescription, over-the-counter, nutritional, supplements, and herbal products. Certain medications like fampridine interact with Inbec Tablet and reduce their effectiveness by causing undesirable side effects. 

• Store Inbec Tablet at 25°C
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• If you forgot to take the tablet, take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.

It is an orally available prescription drug. Your doctor will decide the dose and duration of  Inbec Tablet based on the disease condition and other factors such as body weight and age. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with a glass of water. Do not take an antacid during the 6 hours before you take this medicine or at least 2 hours after you take it.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Inbec side effects are 

Serious

• Heart attack
• Hepatitis B reactivation
• Hypersensitivity allergic reaction

Common 

• Insomnia
• Headache
• Fatigue

• Take the full course of Inbec Tablet as prescribed, even if you feel better after the first few doses.

• Follow your doctor’s instructions regarding the correct dosage.

• Do not take extra doses or double the medicine to make up for a missed dose.

• Inform your doctor if you consume alcohol.

• Calcium or iron supplements (including multivitamins) may be taken with this medicine, but only with food.

• Using this medicine during pregnancy may harm your unborn baby.

• Do not use this medicine during the first 12 weeks of pregnancy.

• Use an effective form of birth control to avoid pregnancy during treatment.

• Do not breastfeed while on this medication, as HIV/AIDS can spread to your baby through breast milk.

• Starting HIV medicines may strengthen your immune system, which can activate hidden infections.

• Inform your doctor immediately if you notice any unusual changes in your health.

1. Triumeq 50 mg/600 mg/300 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published June 2022. Accessed May 16, 2023. https://www.medicines.org.uk/emc/files/pil.3318.pdf

2. Abacavir, Dolutegravir, and Lamivudine - Highlights of Prescribing Information; 2014. Accessed May 16, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/205551s000lbl.pdf

3. KD Tripathi, Essentials of Medical Pharmacology, Antiviral drugs, 7th edition, 2013, 807-808.

4. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Antiretroviral agents and treatment of HIV infection, 12th edition, 2011, 1635-1636.