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Invega Sustenna 150mg Injection
Last updated on 07 Apr 2026 | 10:23 AM (IST)
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Invega Sustenna 150mg Injection
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PALIPERIDONEMarketer
JOHNSON & JOHNSON PVT LTD
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Introduction
Invega sustenna 150mg injection contains an active component as Paliperidone. It is an antipsychotic medication for schizophrenia and related mental disorders like schizoaffective disorder. It belongs to a class of drugs known as atypical antipsychotics. This medication works by affecting certain neurotransmitters in the brain, specifically dopamine and serotonin, which regulate mood, behavior, and cognition. Schizophrenia is a chronic mental disorder characterized by delusions (false beliefs), hallucinations (false perceptions), disorganized thinking, disorganized or catatonic behavior, and negative symptoms such as reduced emotional expression or motivation. Schizoaffective disorder is a condition that combines symptoms of schizophrenia with mood disturbances, such as depression or mania. Individuals with schizoaffective disorder experience a combination of psychotic symptoms and mood episodes.
If you have a known allergy to Invega sustenna 150mg injection or other antipsychotic medications, you should inform your healthcare provider before starting treatment. This medication is contraindicated (not recommended) in individuals with known hypersensitivity or allergy to this medication or any of its components. It should not be used in patients who have experienced severe hypersensitivity reactions to other antipsychotic medications from the same class. Additionally, it should be used cautiously in patients with a history of cardiovascular disease, seizures, or certain medical conditions. It's important to discuss your complete medical history with your healthcare provider before starting this medication or any other medication. Invega SustennaĀ 150mg dosage adjustments may be necessary in patients with renal impairment. The specific age at which Invega sustenna 150mg injection may be considered for pediatric use can vary based on regulatory approvals and clinical guidelines in different countries.Ā invega sustenna 150mg price varies by location and retailer.
Uses
Invega sustenna 150mg uses inĀ the following:
- Schizophrenia treatment
- Schizoaffective disorder treatment
How Invega Sustenna 150mg Injection Works
Invega sustenna injection, an atypical antipsychotic medication, primarily works by blocking dopamine receptors, particularly D2 receptors, in the brain. Reducing excessive dopamine activity helps alleviate the positive symptoms of schizophrenia, like hallucinations and delusions. Additionally, it modulates serotonin receptors, contributing to its effectiveness in managing both positive and negative symptoms. The medication's complex interactions with these neurotransmitter systems contribute to its therapeutic effects in treating schizophrenia and related conditions.
Interaction of Invega Sustenna 150mg Injection with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Invega sustenna 150mg injection, reducing effectiveness by causing undesirable side effects.Ā
Storage Conditions
- Store at room temperature, between 20Ā°C to 25Ā°C (68Ā°F to 77Ā°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets.
How to consume Invega Sustenna 150mg Injection
Invega sustenna 150mg injection is administered through extended-release injection. The injection is administered by a healthcare professional as a monthly injection, gradually releasing the medication over time. The choice of administration route depends on the individual's condition, treatment plan, and the healthcare provider's recommendations.
Safety Advice for Invega Sustenna 150mg Injection
Breast Feeding
The use of Invega sustenna 150mg injection during breastfeeding should be discussed with a healthcare professional.Ā
Alcohol
Consumption of alcohol while taking Invega sustenna 150mg injection can enhance sedation and impair cognitive function. It's advisable to avoid alcohol or use it in moderation, as alcohol can interact with the medication's effects and potentially increase side effects.
Liver
Invega sustenna 150mg injection is metabolized in the liver, so individuals with liver impairment should consultĀ a healthcare provider before using the medication.
Lungs
While Invega sustenna 150mg injection is primarily metabolized in the liver and does not directly affect the lungs, individuals with pre-existing respiratory conditions should inform their healthcare provider before starting the medication.Ā
Driving
Invega sustenna 150mg injection may cause drowsiness, dizziness, or other side effects that can affect your ability to drive or operate machinery safely.
Pregnancy
The use of Invega sustenna 150mg injection during pregnancy should be discussed with a healthcare professional. The potential benefits and risks need to be carefully considered.
Side Effects
Invega sustenna 150mg side effects like all medications, although not everyone will experience them.Ā
Serious:
- Extrapyramidal symptoms
- Neuroleptic malignant syndrome (NMS)
- Tardive dyskinesia
- Cardiovascular effects
- Metabolic changes
- Blood disorders
- Seizures
Common:
- Drowsiness or Sedation
- Dizziness
- Weight Gain
- Increased Heart Rate
- Dry Mouth
- Constipation
Expert tips
-
Avoid use if you have hypersensitivity to paliperidone or risperidone.
-
Use with caution in patients with cardiovascular or cerebrovascular conditions, epilepsy, metabolic disorders, or a history of neuroleptic malignant syndrome (NMS).
-
Regular monitoring is needed for blood glucose, QT interval prolongation, and neutropenia.
-
Watch for orthostatic hypotension, mood changes, or suicidal thoughts and report them promptly.
-
Gradual discontinuation is recommended to prevent withdrawal effects.
-
May cause cognitive and motor impairment, so avoid alcohol, driving, or operating machinery.
-
Be aware of risks like hyperprolactinemia, sensitivity to heat, and special considerations in elderly or pediatric patients.
FAQs about Invega Sustenna 150mg Injection
Q1.
Can I stop taking Invega sustenna 150mg injection suddenly?
No, sudden discontinuation of Invega sustenna 150mg injection can lead to withdrawal symptoms or symptom recurrence. Consult your doctor before making any changes to your medication regimen.
Q2.
What should I Do if I miss a dose?
If you miss a dose, take it as soon as you remember. However, if it's close to the time for the next dose, skip the missed dose and continue with your regular schedule.
Q3.
Can Invega sustenna 150mg injection Be crushed or split?
Invega sustenna 150mg injection tablets should not be crushed, split, or chewed unless your healthcare provider advises. Follow their instructions for proper administration.
Q4.
What should I do if I accidentally take an extra dose ofĀ Invega sustenna 150mg injection?
If you accidentally take an extra dose of Invega sustenna 150mg injection, contact your healthcare provider or seek medical advice for guidance.
Q5.
Can I drink grapefruit juice while taking Invega sustenna 150mg injection?
Avoiding large amounts of grapefruit juice while on Invega sustenna 150mg injection is generally advisable, as it may interact with the medication's metabolism.
Q6.
Can side effects of Ā Invega sustenna 150mg injection impact my mental health?
Some side effects, such as changes in mood or cognition, can impact mental health. Discuss any concerns with your healthcare provider promptly.
Fact Box
|
Molecule name: Paliperidone |
Therapeutic class:Ā Antipsychotic Agents |
|
Pharmacological class: Atypical Antipsychotic AgentsĀ |
Indications:Ā 1. Schizophrenia treatment 2. Schizoaffective disorder treatment |
References
- Goodman & Gilmanās, The Pharmacological Basis of Therapeutics, Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of psychotics and mania, 12th edition, 2011, 428.
- Janssen-Cilag International NV, Electronic medicines compendium (EMC), [Revised on 06 Oct 2021] [ Accessed on 9th August 2023], https://www.medicines.org.uk/emc/product/6816/smpc#gref
- Janssen Pharmaceuticals Inc, US Food and Drug Administration, [Revised on 06/2017] [ Accessed on 9th August 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022264s023lbl.pdf
Disclaimer
MrMedās primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 07 Apr 2026 | 10:23 AM (IST)
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