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Kaviox 500mg Injection
Last updated on 26 Sep 2026 | 08:41 AM (IST)
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Introduction to Kaviox 500mg Injection
Kaviox 500mg Injection contains Avibactam, a non-β-lactam β-lactamase inhibitor belonging to the pharmacological class of beta-lactamase inhibitors. It is used in combination with other antibiotics, such as ceftazidime, to combat resistant bacterial infections. Avibactam inhibits certain β-lactamases produced by resistant bacteria, restoring the efficacy of antibiotics.
Therapeutically, Kaviox 500mg Injection is classified as an antibacterial agent, particularly effective against multidrug-resistant Gram-negative bacteria. It is used to treat conditions like complicated intra-abdominal infections (cIAIs), complicated urinary tract infections (cUTIs), and hospital-acquired bacterial pneumonia (HABP). Patients with renal impairments, pregnancy, or a history of severe allergic reactions to antibiotics should consult their healthcare provider before use. The product should only be administered under medical supervision to ensure safety and efficacy.
Uses of Kaviox 500mg Injection
- Treatment of complicated intra-abdominal infections (cIAIs)
- Management of complicated urinary tract infections (cUTIs), including pyelonephritis
- Treatment of hospital-acquired bacterial pneumonia (HABP) and ventilator-associated bacterial pneumonia (VABP)
- Effective against infections caused by carbapenem-resistant Enterobacteriaceae (CRE)
Therapeutic Effects of Kaviox 500mg Injection
Avibactam works by inhibiting specific β-lactamases, enzymes that bacteria produce to resist antibiotics. This inhibition allows the partner antibiotic, such as ceftazidime, to remain effective against the bacteria. Avibactam does not possess antibacterial activity on its own but enhances the efficacy of β-lactam antibiotics by neutralizing bacterial resistance mechanisms. This dual-action helps in managing infections caused by multidrug-resistant organisms, ensuring better clinical outcomes.
Interaction of Kaviox 500mg Injection with other drugs
Avibactam may interact with other medications, leading to altered efficacy or increased side effects.
Serious drug interactions and contraindications include:
- Probenecid: May increase Avibactam levels by inhibiting its renal excretion, necessitating dose adjustments.
- Aminoglycosides: Concomitant use may increase the risk of nephrotoxicity; monitoring kidney function is advised.
- Penicillin-allergic patients: Cross-reactivity with cephalosporins combined with Avibactam may trigger hypersensitivity reactions.
- Loop diuretics: Concurrent use may increase the risk of kidney damage.
It is essential to inform the healthcare provider of all ongoing medications to avoid serious drug interactions.
More Information about Kaviox 500mg Injection
- Storage: Store at 20°C–25°C (68°F–77°F); avoid exposure to moisture and light.
- Missed dose: Administer as soon as remembered, but skip if close to the next scheduled dose.
- Overdose: Seek immediate medical attention for overdose symptoms like severe nausea or renal issues.
- General: Keep out of reach of children and use only as directed by a healthcare provider.
How to consume Kaviox 500mg Injection
- Recommended dosage is based on patient weight and infection severity; follow the doctor’s prescription.
- Typically administered intravenously over 2 hours in a hospital setting.
- Kaviox 500mg Injection is given in combination with ceftazidime for optimal efficacy.
Safety Advice for Kaviox 500mg Injection
Breast Feeding
Kaviox 500mg Injection may pass into breast milk, posing potential risks to nursing infants. It is generally advised to avoid breastfeeding while on this medication unless deemed essential by your doctor. Discuss alternative feeding methods or options with your healthcare provider during treatment.
Alcohol
No direct interactions between Kaviox 500mg Injection and alcohol have been reported. However, it is advisable to avoid alcohol consumption during the treatment to prevent unnecessary strain on the liver and kidneys. Always follow your doctor’s guidance for safe medication use.
Liver
Patients with liver impairment should use Kaviox 500mg Injection cautiously, as it may require dosage adjustments or additional monitoring. Inform your doctor about any history of liver disease to avoid complications during the course of treatment. Regular liver function tests may be recommended for safety.
Lungs
There are no direct adverse effects of Kaviox 500mg Injection on lung function. It can be safely used in patients without pre-existing severe respiratory conditions. Always inform your doctor if you have any respiratory issues before starting the treatment.
Driving
Kaviox 500mg Injection may cause dizziness or fatigue in some patients, which can impair reaction time and focus. Avoid driving or operating heavy machinery until you know how the medication affects you. If you experience such symptoms, consult your doctor for advice on managing them.
Pregnancy
Limited data is available regarding the use of Kaviox 500mg Injection in pregnant women. It should only be used if the potential benefits outweigh the risks to the fetus, and always under strict medical supervision. If you are pregnant or planning to conceive, consult your doctor before starting this medication.
Side Effects of Kaviox 500mg Injection
Common side effects:
- Nausea
- Diarrhea
- Headache
- Abdominal pain
Serious side effects:
- Severe allergic reactions (rash, swelling, or difficulty breathing)
- Kidney impairment
- Clostridioides difficile-associated diarrhea
- Seizures (rare)
Word of Advice
Patients should complete the prescribed course to prevent antibiotic resistance. Avoid self-medicating or discontinuing treatment without consulting a doctor. Regular monitoring of kidney function is advised for patients with renal issues. Stay hydrated and adhere to medical recommendations for optimal recovery.
FAQs about Kaviox 500mg Injection
Q1.
What is Kaviox 500mg Injection used for?
Kaviox 500mg Injection is used to treat severe bacterial infections, including cIAIs, cUTIs, and hospital-acquired pneumonia, especially those caused by multidrug-resistant bacteria.
Q2.
Is Kaviox 500mg Injection effective against carbapenem-resistant infections?
Yes, Kaviox 500mg Injection is effective against carbapenem-resistant Enterobacteriaceae when combined with ceftazidime.
Q3.
How is Kaviox 500mg Injection administered?
It is administered intravenously over 2 hours in combination with ceftazidime, under medical supervision.
Q4.
Can I take Kaviox 500mg Injection if I have kidney problems?
Yes, but dosage adjustments are necessary, and kidney function should be regularly monitored by a doctor.
Q5.
What should I avoid during treatment with Kaviox 500mg Injection?
Avoid skipping doses and alcohol consumption; inform your doctor about all medications to prevent drug interactions.
Fact Box of Kaviox 500mg Injection
| Molecule name: Avibactam | Pharmacological class: Beta-lactamase inhibitor
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| Therapeutic class: Antibacterial agent | Indications:
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References
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)
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