Kerendia 20mg tablet uses are: 

• Chronic kidney disease (CKD) with type 2 diabetes

Kerendia 20mg Tablet is a selective nonsteroidal mineralocorticoid receptor antagonist (MRA) that blocks the effects of aldosterone, a hormone involved in fluid balance and blood pressure regulation. Inhibiting mineralocorticoid receptors reduces sodium and water retention, prevents potassium excretion, and provides therapeutic benefits in chronic kidney disease, including slowing disease progression, reducing cardiovascular risk, and controlling blood pressure.

• Strong CYP3A4 Inhibitors (Ketoconazole, Itraconazole, Clarithromycin) Severe
  Do not consume Kerendia with these medicines. They can significantly increase finerenone levels, raising the risk of serious side effects such as high potassium.

• Moderate CYP3A4 Inhibitors (Erythromycin, Diltiazem, Verapamil) Moderate
  Use with caution. These medicines may increase finerenone blood levels and the risk of hyperkalemia.

• Strong CYP3A4 Inducers (Rifampicin, Carbamazepine, Phenytoin, St John’s wort) Severe
  Do not consume Kerendia with these medicines. They may reduce finerenone levels and decrease its effectiveness.

• Potassium Supplements and Salt Substitutes Severe
  Avoid concurrent use. This combination can increase potassium levels in the blood and cause serious heart rhythm problems.

• Potassium Sparing Diuretics (Spironolactone, Eplerenone, Amiloride) Severe
  Do not use together. The risk of dangerously high potassium levels is increased.

• ACE Inhibitors and ARBs (Enalapril, Lisinopril, Losartan) Moderate
  Use with caution. Potassium levels should be closely monitored during combined use.

• NSAIDs (Ibuprofen, Diclofenac) Moderate
  Caution is advised. NSAIDs may worsen kidney function and increase the risk of high potassium when taken with Kerendia.

• Store at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• Take only a partial dose to compensate for a forgotten dose.

To use Kerendia 20mg Tablet, follow the prescribed dosage and instructions provided by your healthcare provider. Take the medications as directed, usually orally, with or without food. Do not skip Kerendia dosage or stop taking them without consulting your healthcare provider. Consult your healthcare provider or pharmacist for guidance if you have any questions or concerns.

Kerendia side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. Here are some side effects of Kerendia 20 mg tablets:

Serious

• Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)
• Worsening of kidney function or acute kidney injury
• Liver problems (e.g., jaundice, dark urine, abdominal pain)
• Severe hyperkalemia (symptoms can include muscle weakness, irregular heartbeat, and palpitations)
• Hypotension leading to fainting or loss of consciousness

Common

• Hyperkalemia (high levels of potassium in the blood)
• Diarrhea
• Dizziness
• Fatigue
• Headache
• Nausea
• Hypotension (low blood pressure)

• Follow the recommended dosage and instructions for Kerendia 20mg Tablet.

• Consult your doctor if you are pregnant, planning pregnancy, or breastfeeding, as its use is generally not recommended.

• Avoid high-potassium foods like bananas, oranges, tomatoes, and salt substitutes unless advised otherwise.

• Some people may experience mood changes or symptoms of depression during treatment.

• Use in elderly individuals and children requires special medical consideration.

• Adherence to treatment and open communication with your healthcare provider ensures safe use.

1. Glenmark Pharmaceuticals Europe Limited, Electronic Medicines Compendium, [Revised on Feb 2021] [Accessed on 27th May 2023], https://www.medicines.org.uk/emc/files/pil.9939.pdf
2. 2. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.