• Treatment of acute lymphoblastic leukemia (ALL) as part of a multi-agent chemotherapy protocol.
• Suitable for both pediatric and adult patients diagnosed with ALL.
• Being part of a group of medicines used during early and ongoing treatment stages.
• Helping patients who may be allergic to other types of asparaginase made from E. coli (depending on the formulation).

This medicine works by targeting cancer cells that need a specific protein called asparagine to grow and survive. Normal cells in the body can make their own asparagine, but certain cancer cells, like those found in acute lymphoblastic leukaemia (ALL), cannot. They rely on getting it from the bloodstream. The treatment lowers the level of asparagine in the blood, which starves the cancer cells and helps stop them from growing or spreading.

By cutting off this essential supply, it helps slow down the disease and allows healthy cells to take over. This approach is especially effective in combination with other chemotherapy medicines, forming part of a complete treatment plan for leukaemia. The therapy is typically given in carefully controlled cycles to maximise results while minimising side effects.

Before starting treatment, it’s important to inform your healthcare provider about all medications, supplements, or herbal products you are taking. Some drugs can interfere with how this medicine works or increase the risk of serious side effects. Combining certain therapies may lead to increased toxicity, reduced effectiveness, or complications in treatment.

L Aprakast Injection should not be used in the following situations:

• If there is a history of serious allergic reaction to asparaginase or similar enzyme-based treatments.
• In patients who have experienced severe pancreatitis, bleeding disorders, or liver problems during prior asparaginase therapy.
• If there is pre-existing or active thrombosis (blood clots).
• In individuals with known hypersensitivity to E. coli derived proteins (for formulations derived from E. coli).

Serious drug interactions may occur with:

• Methotrexate: Concomitant use can reduce the effectiveness of both drugs.
• Prednisone: May increase the risk of pancreatitis and other toxicities.
• Vincristine: Co-administration may enhance neurotoxic effects.
• Anticoagulants (e.g., warfarin): Increased risk of bleeding due to clotting abnormalities.

• Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep away from light and out of reach of children.
• If a dose is missed, contact your healthcare provider immediately. Do not attempt to self-administer or double the dose.
• In case of overdose, seek emergency medical attention. Symptoms may include severe allergic reactions, bleeding, or pancreatitis.
• Only a trained healthcare professional should administer this medication in a clinical setting.
• Regular blood tests may be required to monitor liver function, pancreas health, and clotting factors.
• Do not use after the expiry date printed on the packaging.

L Aprakast Injection is given by a healthcare professional in a hospital or clinic setting. It is not taken by mouth and should never be self-administered. The recommended dose varies based on body weight, age, and treatment protocol. It is usually given into a muscle (intramuscular) or vein (intravenous). Food intake does not affect this treatment, as it is not taken orally. Always follow your doctor’s dosing schedule and never miss an appointment for administration.

Common Side Effects:

• Nausea or vomiting
• Loss of appetite
• Fatigue or weakness
• Mild stomach pain
• Joint or muscle pain
• Temporary changes in blood sugar levels

Serious Side Effects:

• Severe allergic reactions (rash, swelling, difficulty breathing)
• Inflammation of the pancreas (pancreatitis) – signs include severe abdominal pain
• Blood clotting issues (easy bruising, unusual bleeding)
• Liver problems (yellowing of skin or eyes, dark urine)
• Changes in mental status such as confusion or drowsiness
• Fever or signs of infection

While undergoing treatment with L Aprakast Injection, it is crucial to attend all follow-up appointments and undergo regular blood tests to monitor liver function, blood cell counts, and signs of infection. Inform your healthcare provider immediately if you experience any unusual symptoms, such as severe abdominal pain or swelling. Ensure you stay hydrated and maintain a balanced diet to support your body during treatment. Be mindful of any changes in your physical or mental health, as these could indicate potential side effects. Always keep your doctor updated on any other medications or supplements you are taking to prevent any unwanted interactions.

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/aspamer080102LB.pdf
2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/101063s5081LBL.pdf
3. https://pmc.ncbi.nlm.nih.gov/articles/PMC4246078/
4. https://pmc.ncbi.nlm.nih.gov/articles/PMC10414282/
5. https://www.cancerresearchuk.org/about-cancer/treatment/drugs/asparaginase