Quick Summary
Lcbuzz 50 Injection
Last updated on 26 Sep 2026 | 08:41 AM (IST)
₹125
MRP: ₹351
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1 VIAL(s) OF 5ML
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₹125
MRP: ₹351.00
Inclusive of all taxes
64% Off
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Introduction
Lcbuzz 50 Injection contains the active substance Leucovorin calcium, which is chemically related to a vitamin called folic acid. It belongs to the class folic acid analogues. It is used to prevent the harmful effects of methotrexate medicine when treating certain types of cancer. It is also used to treat people who have accidentally overdosed on methotrexate medicine or medications that belong to a similar class. It is also used with other anticancer medications to treat colorectal cancer (cancer that begins in the colon or rectum). Other uses include treating anaemia caused by low folic acid levels.
Do not take Lcbuzz 50 Injection if you are allergic to Leucovorin calcium, calcium folinate, or any other ingredients of this medicine if you have certain types of anaemia (pernicious anaemia or megaloblastic anaemia) where vitamin B12 is deficient. Before initiating the treatment, inform your physician if you have anaemia, kidney, heart, or liver problems. Inform your physician if you are using any medications for treating seizures. Notify your physician if you face any symptoms of wheezing or trouble breathing, skin rash, itching or hives, or swelling in the lips, face, or tongue. Lcbuzz 50 price is same across all the locations. You can buy Lcbuzz 50 Injection online in Online platforms like MrMed.
Uses
Lcbuzz 50 Injection uses:
Methotrexate overdose and toxicity
Prevent the harmful effects of methotrexate or similar medications
Colorectal cancer
Anemia
How Lcbuzz 50 Injection Works
Lcbuzz 50 mg Tablet counteracts the therapeutic effects of folic acid antagonists such as methotrexate and similar medications by inhibiting the dihydrofolate reductase enzyme. It treats anaemia by supplying the folic acid needed for red blood cell formation. It treats colorectal cancer by enhancing the therapeutic effects of another anticancer medication called 5-fluorouracil.
Interaction of Lcbuzz 50 Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Lcbuzz 50 Injection and reduce its effectiveness by causing undesirable side effects. Especially inform your physician if you are taking medications for seizures.
Storage Conditions
Store Lcbuzz Tablet in a refrigerator at 2° to 8°C
Keep the injection away from the reach of children and pets.
If you forgot your dosing schedule, inform your healthcare professional immediately and reschedule the dosing
How to take Lcbuzz 50 Injection
A trained physician or nurse in cancer chemotherapy will administer the drug to you. Your doctor will decide the Lcbuzz 50 Injection dosage and duration of the treatment based on your disease condition, severity, and other factors. The medicine is administered either intravenously (into your vein) or intramuscularly (into your muscle) based on your disease condition.
Safety Advices
Pregnancy
There is a limited number of studies on the safety of Lcbuzz 50 Injection during pregnancy, and it is unknown whether the medicine can be given during pregnancy. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Breast Feeding
Limited information is available on Lcbuzz 50 Injection safety during breastfeeding. Inform your physician if you are planning to breastfeed.
Lungs
It is unknown whether Lcbuzz 50 Injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Liver
It is unknown whether Lcbuzz 50 Injection can be used in patients with liver disorders. Consult your doctor if you have any liver diseases before starting the treatment.
Alcohol
It is unknown whether it is safe to consume alcohol when taking Lcbuzz 50 Injection. Consult your doctor for more advice.
Driving
It does not affect the ability to drive or operate heavy machinery after taking Lcbuzz 50 Injection.
Side Effects
Lcbuzz 50mg side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
Diarrhea
Nausea
Vomiting
Inflamed and sore mouth
Tiredness
Serious
Allergic reactions
Expert Tips
If you have a known intolerance to certain sugars, consult your doctor before starting this medicine.
Inform your doctor if you vomit soon after receiving the injection, as it may affect treatment effectiveness.
In the event of an accidental overdose, seek immediate medical attention.
Do not stop taking the medication without your doctor’s recommendation, even if you feel better.
Your doctor may schedule regular lab tests to track how well the medicine is working during the course of treatment.
Frequently Asked Questions(FAQs)
Q1.
Why is Lcbuzz 50 Injection given 24 hours after methotrexate?
Lcbuzz 50 Injection is usually administered 24 hours after methotrexate so that it does not interfere with the therapeutic effect of methotrexate. It can also be used in methotrexate overdose; it should be administered as soon as possible.
Q2.
Can Lcbuzz 50 Injection cause swelling?
Lcbuzz 50 Injection may cause allergic reactions like rash, low blood pressure, wheezing, shortness of breath, and swelling of the face or throat.
Q3.
Can Lcbuzz 50 Injection cause seizures?
There is no evidence that Lcbuzz 50 Injection cause seizures. But the medicine can affect the effect of seizure medication when administered concurrently. Inform your physician about all your medicines, including over-the-counter medications.
Q4.
What time does it take for Lcbuzz 50 Injection to work?
Lcbuzz 50 Injection starts acting on the body within 5 minutes of administration. However, this might vary with respect to dosage, the patient receiving the drug, and response to treatment.
Fact Box
Molecule name: | Leucovorin Calcium |
Pharmacological class: | Folic acid analogues |
Therapeutic class: | 1. Antineoplastics 2. Antidote 3. Rescue agents |
Indications: | 1. Methotrexate overdose and toxicity 2. Prevent the harmful effects of methotrexate or similar medication 3. Anaemia 4. Colorectal cancer |
References
Calcium Folinate 10 mg/ml Injection - Summary of Product Characteristics (SmPC) - (emc) [Internet]. www.medicines.org.uk. 2020 [cited 2023 Apr 4]. Available from: https://www.medicines.org.uk/emc/product/1572/smpc
HIGHLIGHTS OF PRESCRIBING INFORMATION [Internet]. [cited 2023 Apr 4]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/020140s024lbl.pdf
Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Drug toxicity and poisoning, 12th edition, 2011, 86.
KD Tripathi, Essentials of Medical Pharmacology, Haematinics and erythropoietin, 7th edition, 2013, 611.
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
P. Thirumal Reddy
B. Pharm
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:41 AM (IST)
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