Quick Summary
Makenza 160mg Tablet
Last updated on 19 Aug 2026 | 06:50 AM (IST)
₹9188
MRP: ₹26250
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28 TABLET(s) IN A BOTTLE
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MRP: ₹26,250.00
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Introduction
Makenza 160mg Tablet mg Capsule contains Enzalutamide, a targeted therapy classified as an androgen receptor inhibitor. It is commonly prescribed for adults with advanced prostate cancer, especially when the disease no longer responds to surgical or hormonal interventions. This oral anticancer medication works by blocking the effects of male hormones (androgens) that fuel the growth of prostate cancer cells.
Patients on Makenza 160mg Tablet may need regular monitoring through PSA (Prostate-Specific Antigen) blood tests to assess disease progression and treatment response. Liver function tests and complete blood counts are also recommended periodically to track safety during long-term use.
This medication may lower the threshold for seizures and should be used with caution in individuals with a history of neurological conditions. Avoid grapefruit or grapefruit juice, as it may raise drug levels in the blood. Because of its potential to cause infertility and fetal harm, effective contraception is essential for both men and women during and for at least three months after stopping the treatment. Enzabuzz 160 price is the same across all the locations.
Uses
Makenza 160mg Tablet uses:
Used in the treatment of advanced prostate cancer that has not responded to other therapies.
How Makenza 160mg Tablet Works
Enzabuzz 160 mg Tablet works by blocking the androgen receptors on prostate cancer cells. These receptors normally allow the hormone dihydrotestosterone (DHT) to stimulate cancer growth. By preventing DHT from binding, the drug disrupts cancer cell signalling, slows disease progression, and reduces tumour proliferation.
Interaction with Other Medications
Tell your doctor about any prescription drugs, herbal supplements, or over-the-counter medications you take regularly. Enzabuzz Tablet may interact with anticoagulants, anticonvulsants, or drugs affecting liver enzymes. Some interactions may reduce treatment effectiveness or increase the risk of side effects.
Storage
Store in a cool, dry place between 20°C to 25°C.
Keep away from children and pets.
Do not remove capsules from the original packaging until use.
How to Take Makenza 160mg Tablet
Take Makenza 160mg Tablet Capsule exactly as prescribed by your doctor. The standard dose is 160mg once daily, which may be taken with or without food. Swallow the capsules whole with water. Do not crush or open them. If you miss an Makenza 160mg Tablet, take it at the next scheduled time. Do not double up to compensate for a missed dose.
Safety Advice
Pregnancy
Though not used by women, exposure during pregnancy can harm the unborn baby. Men with partners of childbearing age must use contraception during and for 3 months after the last dose.
Breast Feeding
Makenza 160mg Tablet is not intended for use in women, especially during lactation. Speak with your doctor if there is accidental exposure.
Lungs
The safety of Makenza 160mg Tablet in patients with lung diseases has not been established. Report any existing respiratory concerns to your physician.
Liver
Patients with liver conditions should be closely monitored while taking Makenza 160mg Tablet. Liver function tests are advised before and during therapy.
Alcohol
The interaction of Makenza 160mg Tablet with alcohol is not well studied. Avoid alcohol unless your doctor says it is safe.
Driving
This medication may cause dizziness, fatigue, or seizures in rare cases. Avoid driving or operating machinery if these symptoms occur.
Side Effects
Makenza 160mg Tablet side effects. While not everyone experiences them, it’s important to be aware:
Common Side Effects:
Fatigue or tiredness
Back pain or joint stiffness
Headache or difficulty concentrating
High blood pressure
Constipation or diarrhoea
Loss of appetite
Dry skin or skin rashes
Breast swelling in men (gynecomastia)
Serious Side Effects:
Seizures
Allergic reactions
Posterior Reversible Encephalopathy Syndrome (PRES)
Falls or bone fractures
Heart conditions or palpitations
Seek immediate medical help if you experience any signs of severe side effects.
Expert Tips
Take the medicine at the same time daily to maintain consistent drug levels in your body.
Avoid grapefruit juice, which may dangerously increase enzalutamide concentration in the bloodstream.
Use skin moisturisers regularly, as Makenza 160mg Tablet may cause dryness and flaking.
Stay hydrated and eat a balanced diet to manage fatigue and improve treatment tolerance.
Inform all healthcare providers about your treatment if you’re scheduled for surgery or dental work.
Do not stop the medicine abruptly without your oncologist’s advice even if you feel better.
Contraception is crucial: Men must use barrier protection throughout treatment and for 3 months afterwards.
FAQs
Q1.
What is Makenza 160mg Tablet used for?
Makenza 160mg Tablet is prescribed to treat men with advanced prostate cancer, particularly when the disease no longer responds to surgical or hormonal therapy. It’s part of hormone-based treatment plans.
Q2.
Can Makenza 160mg Tablet replace chemotherapy?
Makenza 160mg Tablet is not chemotherapy. Instead, it's a targeted hormone therapy (androgen receptor inhibitor) used with castration or other hormone treatments. It may be used before or after chemotherapy, depending on the stage and patient condition.
Q3.
What are the common side effects from Makenza 160mg Tablet?
Common experiences may include fatigue, back or joint pain, diarrhea, high blood pressure, headache, hot flushes, and swelling in hands or feet.
Q4.
What tests are needed during treatment?
Your doctor will regularly check PSA levels (to monitor cancer response), liver function tests, and blood counts. Blood pressure checks are also common during treatment monitoring.
Q5.
Which serious side effects require immediate attention?
Seek medical help if you encounter seizures, chest pain, significant swelling, fractures, or symptoms of PRES. Though rare, these could indicate severe complications.
Fact Box
Molecule name | Enzalutamide |
Therapeutic class | Antineoplastics |
Pharmacological class | Androgen receptor inhibitors |
Indications | Advanced prostate cancer |
References
Astellas Pharma Ltd, [Revised on Oct 2020] [Accessed on 8th Apr 2021], https://www.astellas.us/docs/12a005-enz-wpi.pdf
Astellas Pharma Europe B.V, Electronic Medicines Compendium (EMC), [Revised on May 2021] [Accessed on 12th Nov 2021], https://www.medicines.org.uk/emc/files/pil.10318.pdf
Martín LázaroQuintela et al., Enzalutamide: a new prostate cancer targeted therapy against the androgen receptor, Cancer Treatment Reviews. Mar 2015; 41(3): 247-253 [Accessed on 8th Apr 2021],https://ruc.udc.es/dspace/bitstream/handle/2183/21551/Lzro_Enzlutamide.pdf?sequence=3&isAllowed=y
Marina D. Kaymakcalan and Christy S. Harris, Prostate Cancer, Applied Therapeutics, The Clinical Use Of Drugs, 11th Edition, 2018, 2083-2100.
Disclaimer
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Author Details
Written By
Dr Arathy J S
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 19 Aug 2026 | 06:50 AM (IST)
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