Meqsel 2mg Tablet has Trametinib as an active agent. It is a prescription medication used to treat certain types of cancers. Cancer is a disorder in which cells multiply uncontrolled and abnormally. This medication inhibits the cell growth and division of cancer cells and used in treatment of advanced melanoma. It is typically used with another drug (dabrafenib) to improve treatment outcomes. This medication is used to treat skin cancer called melanoma which cannot be removed by surgery or has spread to other parts of the body. It also prevents melanoma from returning after being removed from surgery. Also used to treat a kind of lung cancer called non-small cell lung cancer (NSCLC). 

Like all medications, it can cause side effects. The most common side effects include rash, diarrhea, nausea, vomiting, fatigue, and peripheral edema (hand and foot swelling). Talk to your physician if you have liver disorders, kidney disorders, breathing problems, heart diseases, or eye problems before taking Meqsel 2mg Tablet. It is not recommended for adolescents and children under the age of 18 and for also who are allergic to it or one of its components. The recommended dose is one tablet daily, taken orally with or without food. 

• Metastatic melanoma
• Use in combination with dabrafenib for improved treatment outcomes of melanoma
• Used in treatment of non-small cell lung carcinoma
• Used in treating metastatic anaplastic thyroid cancer
• Metastatic solid tumours

Meqsel 2mg Tablet works by blocking the activity of a protein called Mitogen-activated protein kinase kinase (MEK), which is part of the Mitogen-activated protein kinase (MAPK) signaling pathway. This pathway is critical in regulating cell growth, division, and survival. It  helps slow or stop cancer cell growth and spread by blocking MEK.

You should tell the doctor about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Meqsel 2mg Tablet  and reduce effectiveness by causing undesirable side effects.

• Meqsel 0.5 mg Tablet  should be stored at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep in original packaging.
• Protected from light and moisture.
• Keep out of the reach of children and pets.

Meqsel 2mg Tablet  is usually taken orally as a tablet. It can be taken either with or can also be taken without food. Your specific condition, such as medical conditions, age, weight, and overall health, will decide the dosage and duration of treatment. It is essential to follow the instructions provided by the healthcare provider or pharmacist when taking. Generally, the tablet should be swallowed whole with a full glass of water. You should not crush, chew, or break the tablet. If a dose is missed, it is important to take it as soon as possible unless it is almost time for the next scheduled dose. In that case, the missed dose should be skipped, and the regular dosing schedule should be resumed. It would help if you did not take two drug doses together to compensate for a missed dose.

Side effects are unwanted symptoms that occur due to medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Heart failure
• Irregular heartbeat
• Shortness of breath
• Liver injury or hepatitis
• Retinal detachment
• Gastrointestinal perforation (a hole or tear in the stomach or intestine)
• Stevens-Johnson syndrome (a severe skin reaction)

Common:

• Nausea
• Diarrhoea
• Fatigue
• Skin rash
• Acne
• Dry skin
• Headache
• Fever
• Swelling in the hands or feet
• High blood pressure
• Eye problems, such as blurred vision or sensitivity to light

If you have been prescribed Meqsel 2mg Tablet or any other medication, it is important to follow the instructions provided by your healthcare provider and promptly report any side effects or concerns. It can cause serious side effects, so it is important to monitor your symptoms and seek medical attention if you experience any concerning changes in your health. It is also important to avoid alcohol and to follow any safety recommendations provided by your healthcare provider. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately. Patients with liver or kidney disease should use it cautiously. During pregnancy or breastfeeding it is not recommended. Discussing all medical conditions and medications with a healthcare provider before starting treatment is important. With proper monitoring and management, this medication can be an effective treatment option for certain types of cancer.

1. Novartis Europharm Limited, Electronic medicines compendium (emc),[ Revised on Nov 2022] [Accessed on 28th March 2023], https://www.medicines.org.uk/emc/product/5072/smpc
2. Novartis Pharmaceuticals Corporation, US Food and Drug Administration, [Revised on April 2018] [ Accessed on 28th March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/204114s007lbl.pdf
3. Goodman & Gilman's The Pharmacological Basis of Therapeutics, 13th Edition, 2018, 1625-1626
4. Katzung and Trevor, Basic and Clinical Pharmacology, 14th Edition, 2018, 579