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Metalyse 40mg Injection
Prescription Required
Salt Composition : Tenecteplase
Manufacturer : BOEHRINGER INGELHEIM INDIA PVT LTD
Origin of Medicine : Germany
1 Vial(s)
Introduction to Metalyse 40mg Injection
Metalyse 40mg Injection belongs to the antiplatelet agent category, containing the active ingredient Tenecteplase. It is used to prevent blood clots in patients with acute coronary syndrome (ACS), including unstable angina or myocardial infarction (heart attack).
This drug is contraindicated in individuals with known hypersensitivity or allergic reactions to other ingredients in it. If you are scheduled for surgery (including dental work), it is important to inform your doctor. Due to the increased risk of bleeding associated with this drug, your physician may advise you to stop taking the medication five days prior to the surgery.
If you develop irregular breathing patterns such as speeding up, slowing down or experiencing short pauses in breathing, it is recommended to consult your doctor for further evaluation.
Metalyse 40mg Injection is not recommended during pregnancy or if there is a possibility of becoming pregnant. It is advised for women to use appropriate contraceptive measures to prevent pregnancy while using this medication. If you are breastfeeding, it's important to consult with your physician before taking this drug.
Uses of Metalyse 40mg Injection
Metalyse 40mg Injection is used in the treatment of the following:
- Prevent blood clots in patients with acute coronary syndrome (ACS)
Therapeutic Effects of Metalyse 40mg Injection
Metalyse 40mg Injection works by inhibiting platelet activation and aggregation. It specifically blocks a receptor called P2Y12 on the platelets, preventing them from clumping together and forming blood clots. This helps reduce the risk of heart-related events in individuals with ACS.
Interaction of Metalyse 40mg Injection with other drugs
Inform your physician about all your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications such as rosuvastatin, rifampicin, phenytoin, digoxin, cyclosporine, verapamil and opioids may interact with Metalyse 40mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Metalyse 40mg Injection
- Do not store Metalyse 40mg Injection above (30°C).
- Keep out of reach of children.
How to consume Metalyse 40mg Injection
Take the Metalyse 40mg Injection as advised by your physician. Do not crush, chew, or open the medicine. Your physician will decide the correct dosage and duration based on age, body weight, and disease condition. Only stop taking the tablet if your doctor advises you to stop.
Safety Advices for Metalyse 40mg Injection
Pregnancy
Metalyse 40mg Injection is not recommended during pregnancy or if there is a possibility of becoming pregnant. It is advised for women to use appropriate contraceptive measures to prevent pregnancy while using this medication
Breast Feeding
If you are breastfeeding, it's important to consult with your physician before taking Metalyse 40mg Injection.
Lungs
Inform your doctor if you have lung disease because Metalyse 40mg Injection should be used cautiously with a lung condition.
Liver
It is unknown whether Metalyse 40mg Injection is safe for patients with lung problems. Inform your physician if you have lung disease before starting the treatment.
Alcohol
It is unknown whether consuming alcohol interacts with Metalyse 40mg Injection. Please consult your doctor for more advice.
Driving
Metalyse 40mg Injections are not known to cause drowsiness or impair driving ability, so they are generally considered safe for use while driving or operating machinery.
Side Effects of Metalyse 40mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious side effects of Metalyse 40mg Injection are:
- Shortness of breath
- Blood clotting problem called TTP (purplish spots in the mouth or mouth, fever, confusion, yellowing of the eyes or skin, fever)
- Fainting
- Bleeding (red or black stools, coughing up or vomiting with blood, red, pink, or brown urine)
Common side effects of Metalyse 40mg Injection are:
- Headache
- Indigestion
- Nausea
- Constipation
- Rash, itching
- Pain and swelling in the joints
- Blurred vision
- Bleeding gums
- Bruising
Word of Advice
Since Metalyse 40mg Injection affects platelet production, it's essential to take precautions to avoid injuries and bleeding. Be cautious when engaging in activities that may increase your risk of injury, and report any unusual bleeding or bruising to your physician.
FAQs
Q 1. How does Metalyse 40mg Injection work?
Tenecteplase works by inhibiting platelet activation and aggregation. It specifically blocks a receptor called P2Y12 on platelets, which prevents them from sticking together and forming blood clots. This helps maintain blood flow and reduce the risk of cardiovascular events in patients with ACS.
Q 2. How is Metalyse 40mg Injection taken?
Metalyse 40mg Injection is taken orally in tablet form. The usual recommended dose for ACS patients is 180 mg as a loading dose, followed by 90 mg twice daily. It is important to follow the dosing instructions provided by your healthcare provider.
Q 3. What are the common side effects of Metalyse 40mg Injection?
Common side effects of Metalyse 40mg Injection may include bleeding, shortness of breath, headache, dizziness, nausea, and fatigue. It is important to seek medical attention if you experience any signs of bleeding, such as prolonged or excessive bleeding from cuts, blood in urine or stool, or unexplained bruising.
Q 4. Are there any drug interactions with Metalyse 40mg Injection?
Metalyse 40mg Injection may interact with other medications, including prescription drugs, over-the-counter medications, and herbal supplements. It is crucial to inform your healthcare provider about all the medications you are taking to avoid potential interactions that may affect the safety or efficacy of Tenecteplase.
Q 5. What should I do if I miss a dose of Metalyse 40mg Injection?
If you miss a dose of Metalyse 40mg Injection, take it as soon as you remember and then continue with your regular dosing schedule. Do not take a double dose to make up for a missed dose unless advised by your healthcare provider.
Fact Box of Metalyse 40mg Injection
| Molecule name: Tenecteplase | Therapeutic class: Thrombolytics |
| Pharmacological class: Tissue-plasminogen activator (tPA) | Indications: Prevent blood clots |
References
1. Boehringer Ingelheim Ltd, Electronic medicines compendium (EMC), [ Revised on Feb 2023] [ Accessed on 18th July 2023], https://www.medicines.org.uk/emc/files/pil.3013.pdf
2. Genentech, Inc, US Food and Drug Administration, [ Revised on Feb 2018] [ Accessed on 18th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/103909s5187lbl.pdf
3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Modulation of cardiovascular functions, 12th edition, 2011, 866.
4. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding and thrombosis, 7th edition, 2013, 627
Disclaimer
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