Mettaparin H 25000IU Injection is used to treat the following:

• Deep vein thrombosis
• Pulmonary embolism
• Disseminated intravascular coagulation
• Venous thromboembolism prophylaxis
• Atrial fibrillation with a high risk of stroke
• Hemodialysis
• Pregnancy-related thrombosis

Heparin enhances the activity of antithrombin III, a natural anticoagulant protein in the body. By binding to antithrombin III, this medication accelerates its inhibitory effect on clotting factors, particularly thrombin and factor Xa. This inhibition disrupts the blood coagulation cascade, preventing fibrin formation, an essential component of blood clots. As a result, this medication effectively reduces the risk of clot formation and growth, making it a valuable anticoagulant used in various medical conditions.

Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Mettaparin H 25000IU Injection, reducing effectiveness by causing undesirable side effects.

• Store at room temperature, between 20°C to 25°C (68°F to 77°F).
• Keep away from moisture, heat, and light.
• It should not be frozen.
• Keep away from children and pets.

Mettaparin H 25000IU Injection is typically administered either intravenously (IV) or subcutaneously (under the skin). The specific dosage and administration method depends on the medical condition being treated, the patient's weight, age, and other factors, which a healthcare professional should determine. For IV use, this medication is usually given in a hospital setting under continuous monitoring to adjust the dosage as needed. Subcutaneous injections are often used for prophylactic purposes or in outpatient settings.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious side effects of Mettaparin H 25000IU Injection are:

• Severe allergic reactions, including rash, itching, swelling, severe dizziness, or difficulty breathing
• Bleeding
• Heparin-induced thrombocytopenia (HIT)
• Osteoporosis (bone weakness)

Common side effects of Mettaparin H 25000IU Injection are:

• Bruising
• Hematomas
• Pain at the Injection Site
• Redness at the Injection Site
• Elevated Liver Enzymes
• Fever
• Nausea
• Vomiting

Patients should inform their healthcare providers about their medical history, including any bleeding disorders, liver or kidney problems, recent surgeries, and allergies, to determine the appropriate dosage and administration method. Regular monitoring of blood clotting parameters, such as activated partial thromboplastin time (aPTT) or anti-Xa assay, is crucial to maintain the desired anticoagulant effect and prevent bleeding or thrombosis. 

Patients should follow the prescribed dosage and administration instructions precisely and report any unusual bleeding, bruising, or allergic reactions promptly. It is advisable to avoid activities or medications that may increase the risk of bleeding while on heparin. By adhering to these instructions and maintaining open communication with healthcare providers, patients can minimise risks and maximise the benefits of this therapy.

1. Wockhardt UK Ltd, Electronic medicines compendium (EMC), [Revised on June 2018] [ Accessed on 30th July 2023], https://www.medicines.org.uk/emc/files/pil.1678.pdf
2. Baxter Healthcare Corporation, US Food, and Drug Administration, [Accessed on 30th July 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/017037s158lbl.pdf
3. KD Tripathi, Essentials of Medical Pharmacology, Drugs affecting coagulation, bleeding, and thrombosis, 7th edition, 2013, 617