• Treatment of orthostatic hypotension (low BP when a person stands up from a seated or lying)

The therapeutic effect of Midodrive 2.5mg is to increase blood pressure in individuals with low blood pressure or orthostatic hypotension. Acting as an alpha-1 adrenergic agonist and constricting blood vessels, helps to raise peripheral vascular resistance and improve blood flow to vital organs, particularly the brain. This medication enhances blood pressure and offers a therapeutic benefit by improving quality of life, functional capacity, and cognitive function in individuals with orthostatic hypotension.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Midodrive 2.5mg Tablet and reduce effectiveness by causing undesirable side effects. 

• Midodrive 2.5mg Tablet should be stored at room temperature between 68°F to 77°F (20°C to 25°C).
• Keep in the original package.
• Keep away from light, moisture, and heat.
• Keep away from children and pets.

Midodrive 2.5 Tablet is taken orally as a Tablet and should be taken with or without food. The Tablet should be swallowed whole with water and not crushed, chewed, or opened. The dosage and duration of treatment will depend on the individual's condition and response to the medication and should be determined by a healthcare provider.

Midodrive 2.5mg Tablet can cause side effects like all medications, although not everyone who takes it will experience them. 

Serious:

• Chest pain or tightness
• Rapid or irregular heartbeat
• Severe dizziness or lightheadedness
• Shortness of breath or difficulty breathing
• Severe headache
• Blurred vision or other vision changes
• Fainting or loss of consciousness
• Signs of an allergic reaction (e.g., hives, swelling, difficulty breathing)

Common: 

• Scalp tingling or piloerection (goosebumps)
• Itching or rash
• Abdominal discomfort or pain
• Nausea
• Headache
• High blood pressure (especially when lying down)

• It is advised to use caution when using Midodrive 2.5mg Tablet in individuals with pre-existing heart conditions, as it may worsen symptoms.
• It should be used cautiously in individuals with urinary retention and in kidney patients. Any signs of hypersensitivity or allergic reactions should be promptly addressed.
• This medication should be avoided in individuals with pheochromocytoma (a type of adrenal gland tumor) and peripheral vascular disease. Medication should not be discontinued abruptly.
• Pregnancy and breastfeeding are not recommended during treatment before consulting a  doctor.
• It is contraindicated in individuals with hypertension (high blood pressure) or other hypertensive states where a significant increase in blood pressure would be detrimental. This medication should be avoided in heart conditions, such as unstable angina, congestive heart failure, or recent myocardial infarction (heart attack).
• Pediatric and geriatric populations require close monitoring when using Midodrive 2.5mg Tablet.

1. Goodman & Gilman’s, The Pharmacological Basics of Therapeutics, Adrenergic agonists and antagonists, 12th edition, 2011,294-295.
2. Tillomed Laboratories Ltd, Electronic medicines compendium (EMC), [Revised on 16 November 2022], [Accessed on 30th May 2023], https://www.medicines.org.uk/emc/files/pil.12496.pdf 
3. Shrine US, US Food and Drug Administration, [Revised on Jan 2017] [Accessed on 30th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/019815s010lbl.pdf