Netupin Tablet Combi Pack is an anti-emetic drug which contains the active ingredient Netupitant, Palonosetron. These drugs belong to the class of 5-HT3  receptor antagonists, containing the active ingredient Palonosetron. It is used to treat nausea and vomiting associated with chemotherapy (usage of medicines to treat cancer). Nausea is characterised by stomach pain and the urge to vomit. The forcible voluntary or involuntary emptying of the stomach's contents through the mouth is known as vomiting.
 

The common side effects that are likely to occur with this medicine are hives, swollen face, breathing trouble and chest pain. Inform your healthcare provider if these side effects concern you or persist for longer than usual. It is given right away or later with anticancer medicines. It is usually given up to 24 hours while recovering from anaesthesia after surgery. 

Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals in your blood (such as magnesium and potassium). This medicine should not be used if you are allergic to Netupitant, Palonosetron . Tell your physician about all the medications you are taking recently, including herbal medicines and supplements, before taking Netupin Tablet Combi Pack .

Palonosetron  is a prescription medicine, and it is used to treat
 

• Postoperative nausea and vomiting.
• Chemotherapy-induced nausea and vomiting.

Palonosetron is an Isoquinoline derivative that interacts with 5-HT3 receptor antagonists. It is a type of serotonin receptor antagonist that works by blocking the action of serotonin in the body that induces nausea and vomiting. Palonosetron is also effective in the prevention and treatment of nausea and vomiting in patients undergoing radiation therapy to the whole body or abdomen.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Palonosetron and reduce effectiveness by causing undesirable side effects. 

• Store Netupin Tablet Combi Pack in the original package at room temperature (25°C). Do not freeze.
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

The medicine will be administered to you by a qualified healthcare professional in a hospital setting. Netupin Tablet Combi Pack is usually given about 30 minutes before you receive your anti-cancer medicine (chemotherapy) or right before anaesthesia for surgery. If you are taking palonosetron as an oral tablet, it should be swallowed whole with a glass of water, with or without food, as directed by your healthcare provider. Do not crush, chew, or break the tablet before swallowing it.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
 

 Common:

• Headache
• Fatigue
• Dizziness
• Abdominal pain.

 Serious:

• Allergic reactions
• Hives
• Swollen face
• Breathing trouble
• Chest painTalk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals (such as potassium and magnesium) in your blood before taking Netupin Tablet Combi Pack. Inform your doctor or nurse if you are taking any medicines that affect your heart beat because they could cause a heart beat problem when taken with Palonosetron solution for injection.

Talk to your physician if you have a history of repeated constipation, blockage in the bowel, heart problems, or imbalance of certain minerals (such as potassium and magnesium) in your blood before taking Netupin Tablet Combi Pack. Inform your doctor or nurse if you are taking any medicines that affect your heart beat because they could cause a heart beat problem when taken with Palonosetron solution for injection.
 

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2. Fresenius kabi, US Food and Drug Administration, [Revised on Dec 2018] [Accessed on 01st March 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/208109s001lbl.pdf
3. Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Treatment of disorders of bowel motility and water flux, 12th edition, 2011, 1341.
4. KD Tripathi, Essentials of Medical Pharmacology, Antiemetic, prokinetic and digestant drugs, 7th edition, 2013, 669