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NITROL 20MG INJECTION
Salt Composition : Mitoxantrone
Manufacturer : NEON LABORATORIES LTD
Origin of Medicine : India
1 Vial(s) Of 10ml
Introduction to Nitrol 20mg Injection
Nitrol 20mg injection contains the active constituent Mitoxantrone. It belongs to the class of medications called anthracene diones. It is indicated for reducing neurologic disability and the frequency of clinical relapses in patients with secondary (chronic) progressive, progressive relapsing, or worsening relapsing-remitting multiple sclerosis. It is also combined with other medicines to treat patients with pain related to advanced hormone-refractory prostate cancer. It is also indicated in the initial therapy of acute nonlymphocytic leukemia (ANLL) in adults.
Do not take Nitrol 20mg injection if you are allergic to Mitoxantrone or any of the other ingredients. Inform your physician if you have bronchial asthma, liver disorders, kidney disorders, heart problems, infections, or have had chest radiotherapy before taking this medicine. This medicine may cause a blue-green coloration to the urine for 24 hours after administration. Bluish discoloration of the whites of your eyes, skin, and nails may also occur. This medicine may increase the risk for the temporary or persistent absence of menstruation in women of childbearing age. Vaccinations and immunizations may not work during the treatment with this medicine.
Uses of Nitrol 20mg Injection
- Advanced-stage of breast cancer
- Pain caused by prostate cancer at an advanced stage
- Non-Hodgkin’s lymphoma (cancer of the lymphatic system, a part of the immune system
- Acute myeloid leukemia and chronic myeloid leukemia (blood cancers)
- Multiple sclerosis where no alternative therapeutic options exist
Therapeutic Effects of Nitrol 20mg Injection
Nitrol 20mg injection, an antineoplastic drug, is a DNA-reactive agent that intercalates into deoxyribonucleic acid (DNA), causing crosslinks and strand breaks in DNA through hydrogen binding. It also interferes with ribonucleic acid (RNA) and inhibits topoisomerase II, an enzyme responsible for repairing and uncoiling damaged DNA.
Interaction of Nitrol 20mg Injection with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Nitrol 20mg injection and reduce its effectiveness by causing undesirable side effects. Especially, Inform your physician if you are taking any medications for heart problems.
More Information about Nitrol 20mg Injection
- Store vials between 15 and 25 degrees C (59 and 77 degrees F).
- Do not freeze
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you missed the dosing schedule, inform your healthcare professional immediately and reschedule.
How to consume Nitrol 20mg Injection
Nitrol 20mg injection will be administered to you by a doctor or other healthcare professional in a hospital setting trained in cancer chemotherapy. Your doctor will decide the dose, route of administration, and duration of the therapy based on your disease status, severity, and other factors such as body weight, other disease conditions, and age. This medicine will be given intravenously (into your vein). Do not self-administer the injection.
Safety Advices for Nitrol 20mg Injection
Do not take Nitrol 20mg injection if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment. Use effective contraception during the treatment.
Breastfeeding is not recommended in patients taking Nitrol 20mg injection because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
It is unknown whether Nitrol 20mg injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Nitrol 20mg injection should be cautiously administered in patients with liver failure. Dose adjustments are necessary. However, inform your physician if you have any liver diseases before initiating the therapy.
It is unsafe to consume alcohol with Nitrol 20mg injection because it may affect the effectiveness of the therapy.
Nitrol 20mg injection alters the ability to drive. Do not drive if you experience any symptoms that affect your ability to concentrate and react. Consult your doctor for more advice.
Side Effects of Nitrol 20mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
- Decreased hemoglobin count
- Decreased WBC count
- Urinary tract infection
- Menstruation problem
- Heart problems
- Liver injury
Word of Advice
If the medicine gets in your eyes, rinse your eyes with large amounts of water, and tell your doctor. It is not safe to take this medicine during pregnancy. It could harm an unborn baby. Inform your physician if you have liver disease, anemia, blood clotting problems, bone marrow problems, low white blood cell counts, bleeding problems, or any kind of infection.
This medicine may change the color of your urine to bluish-green. The whites of your eyes may also appear slightly bluish-green. This is normal, especially within the first 24 hours after you receive the medicine. This medicine may make you bleed, bruise, or get infections more easily. Take precautions to prevent illness and injury. Your doctor will do lab tests at regular visits to check on the effects of this medicine. Keep all appointments. Your doctor may also want to check your heart while you are using this medicine.
Q 1. Why is my urine bluish-green after taking Nitrol 20mg injection?
This medicine may change the color of your urine to bluish-green. The whites of your eyes may also appear slightly bluish-green. This is normal, especially within the first 24 hours after you receive the medicine.
Q 2. What if I miss a dose of Nitrol 20mg injection?
Do not miss your dose. Keep all your appointments with the dosing regularly. In case if you forget or missed an appointment, inform your healthcare professional and reschedule the dosing.
Q 3. Are there any special dietary instructions I should follow while taking Nitrol 20mg injection?
Unless your doctor tells you to avoid certain foods, continue your normal diet. Consult your doctor for more advice on dietary restrictions.
Q 4. Does Nitrol 20mg injection cause hair loss?
Since the growth of normal body cells may also be affected by Nitrol 20mg injection, other unwanted effects will also occur. Some of these may be serious and must be reported to your doctor. Other effects, like hair loss, may not be serious but may cause concern.
Q 5. How is Nitrol 20mg injection excreted?
Nitrol 20mg injection is excreted in urine and feces.
Fact Box of Nitrol 20mg Injection
Molecule name: Mitoxantrone
Therapeutic class: Antineoplastics
Pharmacological class: Anthracene diones
1. Advanced-stage of breast cancer
2. Pain caused by prostate cancer at an advanced stage.
3. Non-Hodgkin’s lymphoma (cancer of the lymphatic system, a part of the immune system.
4. Acute myeloid leukemia and chronic myeloid leukemia (blood cancers)
5. Multiple sclerosis where no alternative therapeutic options exist
- EMD Serono, Inc, US Food and Drug Administration, [Issued on Aug 2008] [ Accessed on 06 May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/019297s030s031lbl.pdf
- LE Posner; Mitoxantrone: an overview of safety and toxicity; Investigational New Drugs; Published on 1985; Accessed on 06 May 2023; https://pubmed.ncbi.nlm.nih.gov/3894276/
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