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Nucala 100mg Injection PFS
Last updated on 23 Jul 2026 | 03:20 PM (IST)
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1 PREFILLED SYRINGE (s) OF 1ML
Nucala 100mg Injection PFS
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₹69000
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GLAXO SMITHKLINE PHARMACEUTICALS LTD
Prepaid Only. Non-Returnable.
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Introduction to Nucala 100mg Injection PFS
Nucala 100mg Injection PFS contains the active compound Mepolizumab. It falls under the category of monoclonal antibodies. This drug treats specific respiratory conditions, specifically severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis (EGPA), also known as Churg-Strauss syndrome. Severe eosinophilic asthma is characterised by elevated eosinophils (type of white blood cell). Despite regular treatment, it leads to recurring asthma attacks. EGPA, on the other hand, is a rare autoimmune disease that causes inflammation of blood vessels and infiltration of eosinophils into different organs. This condition results in respiratory symptoms, systemic manifestations, and potential organ damage.
Nucala 100mg Injection PFS is not intended to treat acute asthma attacks or acute exacerbations. It is a maintenance therapy to manage chronic eosinophilic asthma and prevent future exacerbations. It may suppress the immune system, making avoiding its use during active bacterial or viral infections important. This medication is not approved for children under the age of 6 years. It is advisable to ask a doctor regarding vaccination schedules and appropriate timing.
Uses of Nucala 100mg Injection PFS
- Eosinophilic asthma
- Eosinophilic granulomatosis with polyangiitis (EGPA)
Therapeutic Effects of Nucala 100mg Injection PFS
Nucala 100mg Injection PFS exerts its therapeutic effects by targeting and blocking interleukin-5 (IL-5), a protein involved in the production and activation of eosinophils. By inhibiting IL-5, this medication reduces the eosinophils numbers in the blood, lungs, and tissues. This eosinophil reduction helps alleviate inflammation and symptoms associated with severe eosinophilic asthma and eosinophilic granulomatosis with polyangiitis (EGPA)
Interaction of Nucala 100mg Injection PFS with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Nucala 100mg Injection PFS and reduce effectiveness by causing undesirable side effects.
More Information about Nucala 100mg Injection PFS
- Nucala 100mg Injection PFS should be stored in the refrigerator at a temperature range between 2°C to 8°C (36°F to 46°F).
- Do not freeze it.
- Keep it in the original package.
- Keep away from light, moisture, and heat.
- Keep away from children and pets.
- Avoid taking double doses for missed doses.
How to consume Nucala 100mg Injection PFS
Nucala 100mg Injection PFS is given as an injection by healthcare professionals. The dosage and duration of treatment will depend on the individual's condition and response to the medication and should be determined by a healthcare provider.
Safety Advice for Nucala 100mg Injection PFS
Breast Feeding
Whether Nucala 100mg Injection PFS is excreted in milk is unknown. So it is better to consult a healthcare provider if you are a breastfeeding mother before taking this medication.
Alcohol
It is generally recommended to avoid or limit alcohol consumption while taking Nucala 100mg Injection PFS. Alcohol can interact with this medication and potentially increase the risk of side effects.
Liver
Nucala 100mg Injection PFS is primarily metabolized in the liver, and its safety has not been extensively studied in individuals with severe liver impairment. Communicating any pre-existing liver conditions or changes in liver function to your healthcare provider is crucial to ensure safe and effective use.
Lungs
If you have a lung or respiratory disorders history, it is important to consult your healthcare provider before taking Nucala 100mg Injection PFS.
Driving
Patients receiving Nucala 100mg Injection PFSs should be advised to avoid driving or operating machinery if they experience side effects such as fatigue, dizziness, or blurred vision, impairing a patient's ability to drive or operate machinery safely.
Pregnancy
The safety of using Nucala 100mg Injection PFS during pregnancy has not been established. Limited studies are available regarding the use of this medication in pregnant women, so it is recommended to use caution and consult a doctor before considering its use during pregnancy.
Side Effects of Nucala 100mg Injection PFS
Nucala 100mg Injection PFS can cause side effects like all medications, although not everyone who takes it will experience them.
Serious:
- Severe allergic reactions
- Anaphylaxis (a severe and potentially life-threatening allergic reaction)
Common:
- Headache
- Injection site reactions (e.g., pain, redness, swelling)
- Upper respiratory tract infection
- Back pain
- Fatigue
- Fever
- Nausea
- Muscle pain (myalgia)
- Influenza (flu)-like symptoms
Word of Advice
Attend all scheduled appointments and follow-up visits to monitor your response to treatment and address any concerns or side effects. Tell your doctor about your medical history, any previous infection, liver disease, and kidney disease. Seek immediate medical attention if you experience severe allergic reactions or other serious side effects. Avoid close contact with an infected person. Do not change your Nucala 100mg Injection PFS treatment or corticosteroid dose without consulting your healthcare professional. Inform your doctor's provider. Avoid taking any vaccines during treatment. The safety and efficacy in children below six years of age group have not been established.
FAQs about Nucala 100mg Injection PFS
Q1.
Can I stop taking my other asthma medications once I start Nucala 100mg Injection PFS?
Nucala 100mg Injection PFS is not intended to replace other asthma medications, including inhalers or oral medications. It is typically used as an add-on treatment for individuals with severe eosinophilic asthma who require additional control of their symptoms. Your healthcare professional should discuss and determine the use of other asthma medications.
Q2.
Can I receive vaccinations while on Nucala 100mg Injection PFS?
Discussing vaccination schedules and specific vaccines with your healthcare professional while on Nucala 100mg Injection PFS is recommended. It may affect the effectiveness of certain vaccines, particularly live vaccines. Your healthcare professional can guide the appropriate timing and administration of vaccinations.
Q3.
Will Nucala 100mg Injection PFS cause weight gain?
Weight gain is not commonly reported as a side effect of Nucala 100mg Injection PFS. However, individual responses to medication can vary, and some may experience weight gain due to other factors. If you have concerns about weight changes while on taking it, discuss them with your healthcare professional.
Q4.
How long does it take for Nucala 100mg Injection PFS to start working?
The response to Nucala 100mg Injection PFS can vary among individuals. Some people may experience improved symptoms, such as reduced asthma exacerbations or improved lung function, within a few weeks of starting treatment. However, it may take several months to observe the full benefits ofthis medication. Regular follow-up with your healthcare professional is important to assess your response to treatment.
Q5.
Can Nucala 100mg Injection PFS be used in older adults?
Considering their overall health and potential interactions with other medications, Nucala 100mg Injection PFS can be used in older adults with severe eosinophilic asthma or EGPA. However, individual assessment and monitoring by a healthcare professional are important to determine the suitability and safety of this medication in older adults.
Fact Box of Nucala 100mg Injection PFS
Molecule name: Mepolizumab
| Therapeutic class: Anti-asthmatic agent |
| Pharmacological class: Monoclonal antibodies | Indications: 1. Eosinophilic asthma 2. Eosinophilic granulomatosis with polyangiitis (EGPA) |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, 12th edition, 2011,1044-1046.
- Glaxo Smith Kline, Electronic medicines compendium (EMC), [ Revised on 16 November 2022], [ Accessed on 30th May 2023],
- GlaxoSmithKline LLC, US Food and Drug Administration, [ Revised on June 2019] [ Accessed on 30th May 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/761122s000lbl.pdf
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 23 Jul 2026 | 03:20 PM (IST)
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