NUPARP 300MG TABLET

Introduction:

Nuparp 300mg Tablet is an anti-cancer agent containing the active constituent rucaparib. It is used for the maintenance treatment of patients with ovarian cancer, fallopian tube cancer, or primary peritoneal cancer. It is used after cancer has responded to previous chemotherapy treatments. It can also be used to treat if your cancer has come back after the chemotherapy and you have an abnormality of the BRCA gene. Cancer is a disorder in which cells multiply in an uncontrolled and abnormal manner.

Nuparp 300mg Tablet is not recommended for adolescents and children under the age of 18. Use effective birth control during the treatment and for at least 6 months after the last dose. Limit your exposure to sunlight as you may get sunburn easily during the treatment. Use sunscreen products with a sun protection factor of 50 or higher.

Talk to your physician if you have any diseases or allergic conditions and if you are taking medicines for them before starting treatment with Nuparp 300mg Tablet.

Uses of Nuparp 300mg Tablet:

Nuparp 300mg Tablet is used for maintenance treatment of:

• Ovarian cancer
• Fallopian tube cancer
• Primary peritoneal cancer

How Nuparp 300mg Tablet works:

Nuparp 300mg Tablet inhibits the enzyme PARP (poly adenosine diphosphate-ribose polymerase), damages the DNA, and prevents the cancer cells from growing and multiplying. 

Interactions with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More information:

• Keep Nuparp 300mg Tablet out of sight and reach of children.
• Store at room temperature (20°C to 25°C).

References:

1. Clovis Oncology Ireland Ltd, Electronic medicines compendium (emc), [Revised on Jan 2021] [ Accessed on 19th August 2021], https://www.medicines.org.uk/emc/files/pil.10027.pdf
2. Clovis Oncology, Inc, US Food and Drug Administration, [Revised on April 2018] [ Accessed on 19th August 2021], https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/209115s003lbl.pdf
3. Prof Robert L Coleman et al; Rucaparib maintenance treatment for recurrent ovarian carcinoma after response to platinum therapy (ARIEL3): a randomised, double-blind, placebo-controlled, phase 3 trial; Lancet; Published on 28/10/2017; Accessed on 19/08/2021; https://www.ncbi.nlm.nih.gov/pubmed/28916367

How to use Nuparp 300mg Tablet:

Take Nuparp 300mg Tablet in a dose and duration prescribed by your doctor. Swallow the tablets whole with water. Do not crush or chew the tablets.

Safety advice:

Pregnancy:

Nuparp 300mg Tablet should not be taken during pregnancy as it can harm the baby. You need to tell your physician if you are pregnant or planning to get pregnant before taking this medicine. 

Breastfeeding:

Nuparp 300mg Tablet is contraindicated in breastfeeding women. You need to tell your physician if you are breastfeeding before taking this medicine. 

Liver:

You need to tell your physician if you have any liver disorders before taking Nuparp 300mg Tablet. 

Kidney:

You need to tell your physician if you have any kidney disorders before taking Nuparp 300mg Tablet. 

Driving: 

Nuparp 300mg Tablet can cause dizziness or tiredness. Avoid driving if you are unwell.

Others:

• Limit your exposure to sunlight as you may get sunburn easily during the treatment. Use sunscreen products with the sun protection factor of 50 or higher.
• Talk to your physician if you have any allergic conditions or diseases before taking Nuparp 300mg Tablet.

Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.

Serious:

• Fever or infection
• Bleeding or bruising
• Shortness of breath, having pale skin, or fast heartbeat, feeling tired

Common:

• Diarrhea
• Nausea, vomiting
• Stomach pain
• Taste change
• Loss of appetite
• Dizziness
• Heartburn
• Sunburn
• Rash, itching
• Difficulty breathing
• High cholesterol levels
• Indigestion
• Dehydration