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Nuparp 300mg Tablet
Prescription Required
Salt Composition : Rucaparib
Manufacturer : ZYDUS CADILA
Origin of Medicine : India
60 Tablet(s) In A Bottle
Introduction to Nuparp 300mg Tablet
Nuparp 300mg tablet contains the active ingredient rucaparib. It is an anti-cancer medicine that belongs to the class of medications called PARP (poly ADP-ribose polymerase) inhibitors. It is used to help maintain the response to other treatments for certain types of ovarian cancer, fallopian tube (a tube that transports eggs released by the ovaries to the uterus), and primary peritoneal (layer of tissue that lines the abdomen) cancer that has reoccurred in adults who have previously completely responded or partially responded to other chemotherapy treatments.
It is also used to treat certain types of cancer in people with specific gene (BRCA) changes who have received treatment with at least two other chemotherapy treatments. It is also indicated as maintenance therapy immediately after chemotherapy which has caused the tumor to shrink. Do not take Nuparp 300mg tablet if you are allergic to Nuparp or any of the ingredients. This medication can cause low blood counts; hence your healthcare professional will advise you to take certain blood tests before and every month during the treatment.
Inform your doctor if you have nausea, vomiting, diarrhea, or abdominal pain during the treatment because this medicine may affect your stomach or bowels. Nuparp 300mg tablet should not be given to children under 18 years of age. Notify your physician if you are pregnant, breastfeeding, suspecting, or planning for pregnancy during the treatment with this medicine. Women with reproductive potential should use effective contraception during the treatment.
Uses of Nuparp 300mg Tablet
- Ovarian cancer
- Fallopian tube cancer
- Primary peritoneal cancer
- Prostate cancer
Therapeutic Effects of Nuparp 300mg Tablet
Nuparp 300mg tablet is an inhibitor of poly Adenosine diphosphate-ribose polymerase enzymes, including PARP-1, PARP-2, and PARP-3, which play a role in DNA repair. It blocks an enzyme that repairs damaged DNA in the cancer cells, resulting in their death.
Interaction of Nuparp 300mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Nuparp 300mg tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Nuparp 300mg Tablet
- Store at 20°C to 25°C
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you forgot to take the tablet, take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
How to consume Nuparp 300mg Tablet
It is an orally available prescription drug. Your doctor will decide the dose and duration of Nuparp 300mg tablet based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water.
Safety Advices for Nuparp 300mg Tablet
Pregnancy
Do not take Nuparp 300mg tablet if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting, or planning to get pregnant during the treatment. Use effective contraception during the treatment and for 6 months after the last dose.
Breast Feeding
Breastfeeding is not recommended in patients taking Nuparp 300mg tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Lungs
It is unknown whether Nuparp 300mg tablet is safe to be administer in patients with lung diseases. Inform your physician if you have any lung diseases before initiating the therapy.
Liver
Nuparp 300mg tablet is safe when administered in patients with liver disease. No dose adjustments are necessary.
Alcohol
It is not known whether it is safe to consume alcohol with Nuparp 300mg tablet. Please consult your doctor.
Driving
Nuparp 300mg tablet may cause dizziness and drowsiness. Driving or operating heavy machinery is unsafe if you experience any symptoms that affect your ability to concentrate and react.
Side Effects of Nuparp 300mg Tablet
Nuparp 300 side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Rash
- Constipation
- Decrease in appetite
- Diarrhea, indigestion
- Nausea, vomiting
- Changes in the blood count
- Shortness of breath
- Tiredness
Serious
- Severe anemia
- Hypersensitivity reactions
- Sepsis (blood infection)
- Pneumonia
Word of Advice
You may get sunburn easily during treatment with Nuparp 300mg tablet. Keep out of direct sunlight and wear protective clothing that covers your head, arms, and legs. Use sunscreen and lip balm with a sun protection factor (SPF) after consulting your doctor. If you vomit after taking the medicine, do not take an extra dose. Take your next dose at the regular time. Do not stop taking this medicine without talking to your doctor. Your doctor may do lab tests to check the therapy's effectiveness or monitor the unwanted side effects.
FAQs
Q 1. Is it safe to administer Nuparp 300mg tablet in patients with kidney disease?
Yes, it is safe to administer Nuparp 300mg tablet in patients with kidney disease. No dose adjustments are necessary. Inform your physician if you have kidney disorders before initiating the therapy.
Q 2. What should I tell my healthcare provider before taking Nuparp 300 tablet?
Inform your physician about all your past medical and medication history, including over-the-counter medicines, nutritional or vitamin supplements that you are taking.
Q 3. I am a male patient. Do I have to use contraception during the treatment with this medicine?
Yes, male patient with female partner of reproductive potential should use effective contraception during the treatment and for 3 months after the last dose of Nuparp 300mg tablet.
Q 4. Do I have to wear sunscreen while taking Nuparp 300mg tablet?
Yes, this medicine makes your skin more sensitive to sunlight. Wear sunscreen during the treatment after consulting your doctor.
Q 5. How long do I have to take Nuparp 300mg tablet?
The duration of your treatment depends on your disease condition and severity. Your doctor will decide your dose, and duration of your treatment.
Fact Box of Nuparp 300mg Tablet
Molecule name: Rucaparib | Therapeutic class: Anti-cancer |
Pharmacological class: PARP inhibitors | Indications: 1. Ovarian cancer 2. Fallopian tube cancer 3. Primary peritoneal cancer 4. Prostate cancer |
References
- Rubraca 250mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. [revised on 2022] [cited 2023 Apr 11]. Available from: https://www.medicines.org.uk/emc/product/10027/smpc
- HIGHLIGHTS OF PRESCRIBING INFORMATION - Rucaparib. [revised on 2018] [cited 2023 Apr 11]. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/209115s003lbl.pdf
- Shirley M. Rucaparib: A Review in Ovarian Cancer. Targeted Oncology. [2019 Apr 1] [cited 2022 Oct 15];14(2):237–46. Available from: https://pubmed.ncbi.nlm.nih.gov/30830551/
Disclaimer
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