The Onbort 2mg Injection is used in the following:

• Treatment of multiple myeloma

• Treatment of mantle cell lymphoma

Onbort 2mg Injection works by exerting a toxic effect on cancer cells. It inhibits the 26s proteasome and blocks a major cell-signalling pathway. This inhibition of the signalling pathway makes the cancer cells sensitive to chemotherapy. By inhibiting the proteasome, Onbort 2mg Injection disrupts the normal process of protein degradation within the cell. This leads to the accumulation of misfolded or damaged proteins, which are toxic to the cell. The accumulation of misfolded proteins triggers a series of cellular responses, including the activation of stress pathways and the induction of apoptosis. This medicine also enhances the build-up of a protein and minimises cancer cell growth and multiplication.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Onbort 2mg Injection and reduce effectiveness by causing undesirable side effects.

• Store Onbort 2mg Injection in a refrigerator (2°C – 8°C).
• Do not freeze.
• Protect the medicine from light and excessive moisture.
• Keep the medicine out of reach of children and pets
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

Onbort 2mg Injection is administered by injection intravenously in your vein or subcutaneously under the skin. It is given in by a healthcare professional in a hospital setting. The dosage and frequency of Onbort 2mg Injection will depend on various factors, including the patient's age, weight, overall health, and the type and stage of disease being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first. Do not self-administer this injection. If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It's important not to take a double dose of Onbort 2mg Injection to make up for a missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

Serious side effects of Onbort 2mg Injection are:

• Peripheral neuropathy
• Hypotension
• Cardiac toxicity
• Posterior Reversible Encephalopathy Syndrome (PRES)
• Tumor Lysis Syndrome
• Hepatic Toxicity
• Thrombotic Microangiopathy

Common side effects of Onbort 2mg Injection are:

• Loss of appetite
• Sensitivity, tingling and burning sensation of the skin
• Nausea, vomiting, and diarrhea
• Mouth ulcers
• Constipation
• Muscle and bone pain
• Hair loss
• Fever
• Reduction in blood cell count
• Reduced kidney function
• Shivering
• Infections
• Dehydration
• Stomach problems
• Difficulty sleeping, anxiety, mood swings, depressed mood

If you have been prescribed Onbort 2mg Injection it is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly. Even if you feel better or see a change in your symptoms, you should still talk to your doctor before stopping Onbort 2mg Injection. It is advised that both men and women must use an effective contraception method during treatment and three months afterward. Treatment with Onbort 2mg Injection can commonly cause a decrease in the number of red and white blood cells and platelets in your blood. Therefore, you will have to take regular blood tests before and during your treatment with Onbort 2mg Injection to check your blood cell counts regularly. Include anti-inflammatory foods in your diet, such as olive oil, nuts, seeds, fruits, vegetables, and fatty fish. 

Include foods like avocados, almonds, seeds, and olive oil in your diet as sources of healthful fats. These fats can improve general health by lowering inflammation. To stay hydrated, sip lots of water throughout the day.  Monitor your blood sugar level frequently If you are taking antidiabetic medication and report to your physician if you notice any fluctuations in your blood sugar levels.

Consult your physician before getting any vaccinations because certain of them can make you sick and should not be administered while you are on this medication. If you currently have or have ever had hepatitis B, let your doctor know. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately.

1. Tillomed Laboratories Ltd, Electronics Medicines Compendium(emc), [ Revised on November 2022] [ Accessed on 02-04-2024], https://www.medicines.org.uk/emc/files/pil.12587.pdf

2. MAIA Pharmaceuticals, Inc,  United States Food and Drug Administration (US FDA), [ Revised on July 2022] [Accessed on 02-04-2024], https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/215331s000lbl.pdf

3. Pfizer, [Accessed on 02-04-2024],  https://labeling.pfizer.com/ShowLabeling.aspx?id=15338

4. Dr. Reddy’s Laboratories Limited, [Revised on April 2016], [Accessed on 02-04-2024], https://www.drreddys.com/media/503329/bortezomib-en.pdf