Pazotab 200mg tablet contains the active substance pazopanib. It is an antineoplastic drug that belongs to the class tyrosine kinase inhibitor. It is used in adults to treat advanced kidney cancer or has spread to other organs. It is also indicated to treat certain forms of soft-tissue sarcoma, a type of cancer affecting the supportive tissues of the body. This medicine works by preventing the activity of proteins involved in the growth and spread of cancer cells. 

Do not take Pazotab 200mg tablet if you are allergic to Pazopanib or any other ingredients of this medicine. Before initiating the treatment, inform your physician if you have kidney, heart, lung, or liver problems, bleeding disorders, stomach or bowel problems, and thyroid problems. This tablet can raise your blood pressure. It is necessary to check your blood pressure regularly during the treatment. No dose adjustments are required for patients with kidney diseases. 

Your doctor will advise you to stop Pazotab 200mg tablet at least 7 days before any surgeries or dental operations that you are undergoing, as it may affect wound healing. This medicine is not recommended for people aged under 18. This medicine can cause infertility; consult your doctor before taking this medicine. The most common side effects are diarrhea, hypertension, hair color changes, nausea, and vomiting.

• Advanced renal cell carcinoma
• Advanced soft tissue sarcoma

Pazotab 200mg tablet is a biological agent that acts as targeted drug therapy in cancer treatment. It is an anticancer medication that belongs to the category of tyrosine kinase inhibitors. It interferes with the growth of blood vessels inside the cancer cells by acting against a protein called Vascular Endothelial Growth Factors (VEGF) to shrink cancer cells, ultimately stopping their growth and multiplication.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with the effects of Pazotab 200mg tablet and reduce its effectiveness by causing undesirable side effects.

• Store Pazotab 200mg tablet in room temperature (25°C)
• Keep the injection away from the reach of children and pets.
• If you forgot to take a dose, take it as soon as you remember. However, skip the missed dose if it is nearly time for the next dose.
• Do not take a double dose to make up for a forgotten dose.

Your doctor will decide the dose and duration of the treatment based on your disease condition, severity, and other factors. Take the tablets as prescribed by your doctor. Do not break, crush, or chew the tablets. Swallow the tablet whole with a glass of water. Do not take this medicine with food, as it affects the absorption of this medicine. Take Pazotab 200mg tablet at least two hours after a meal or one hour before a meal. 

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them. 

 Common

• Hypertension
• Hair color change
• Increased glucose levels
• Decreased weight, decrease in appetite
• Diarrhea
• Nausea, vomiting
• Muscle and joint pain
• Headache
• Shortness of breath
• Tiredness

Serious

• Heart problems
• Bleeding from the anus, mouth
• Hypothyroidism
• Interstitial lung disease
• Infections

Do not drink grapefruit juice during the treatment with this medicine, as this may increase the chance of side effects. Male patients with female partners with reproductive potential should use effective contraception during the treatment and at least 2 weeks after the last dose to prevent pregnancy. Take the tablet at about the same time each day. Your doctor will regularly do lab tests to check whether the medicine works for you.

1. Highlights Of Prescribing Information - Pazopanib. [Revised on 2021] [cited 2023 Mar 24]. Available from: https://www.novartis.com/us-en/sites/novartis_us/files/votrient.pdf
2. Summary Of Product Characteristics - Pazopanib. [revised on 2021] [cited 2023 Mar 24]. Available from: https://www.ema.europa.eu/en/documents/product-information/votrient-epar-product-information_en.pdf
3. Votrient 400 mg film coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. 2021 [cited 2023 Mar 24]. Available from: https://www.medicines.org.uk/emc/product/572/smpc
4. Edward Chu, Cancer Chemotherapy, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 948-976.