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Pemejas 500mg Injection
Last updated on 14 May 2026 | 06:20 AM (IST)
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Introduction to Pemejas 500mg Injection
Pemejas 500mg Injection is an anticancer medicine containing the active ingredient pemetrexed. It belongs to the medication class known as an antifolate agent. It is used to treat non-small cell lung cancer and malignant pleural mesothelioma (cancers of the lungs and chest). Pemejas 500mg Injection is given alone or in combination with another anticancer medicine, such as cisplatin. Your doctor may prescribe corticosteroids, folic acid, and vitamin B12 to limit the side effects.
Blood tests will be taken before each infusion to determine whether your kidney and liver functions are adequate and whether you have enough blood cells to receive this medicine. Before starting treatment with Pemejas 500mg Injection, it is very important to tell your physician if you have currently or previously had any medical conditions of kidney problems, heart disorders, or fluid accumulation in the lungs.
Report your doctor if you recently had or are currently having radiotherapy or any vaccination before taking this medication. Inform your doctor immediately if you are planning to get pregnant or think you may be pregnant. Use effective birth control during the treatment and at least six months after the last dose of Pemejas 500mg Injection.
In men, it is recommended not to father a child during and up to 3 months after the treatment. So it is advised to get suggestions about fertility concerns from your doctor. This medication is not recommended for adolescents and children under 18 years of age.
Uses of Pemejas 500mg Injection
- Malignant pleural mesothelioma
- Non-small cell lung carcinoma
Therapeutic Effects of Pemejas 500mg Injection
Pemejas 500mg Injection inhibits the mechanism required for cell division and replication by blocking specific enzymes involved in folate metabolism (essential for cell replication) and DNA synthesis, which will prevent the cancer cells from growing and multiplying.
Interaction of Pemejas 500mg Injection with other drugs
Inform your healthcare provider about all your medicines, including prescribed medications, over-the-counter medicines, nutritional or vitamin supplements, and herbal products. Certain medications such as may interact with Pemejas 500mg Injection and reduce effectiveness by causing undesirable side effects.
More Information about Pemejas 500mg Injection
- Keep the tablets away from light and moisture.
- Store refrigerated at 2°C to 8°C.
- Keep the tablets out of the reach of children and animals.
How to consume Pemejas 500mg Injection
Pemejas 500mg Injection is administered as an intravenous infusion into the vein. If this injection is recommended for you, it will be given by a healthcare professional. Do not self-administer. Your physician will choose the dosage and administration frequency based on the medical condition because it differs for each person.
Safety Advice for Pemejas 500mg Injection
Breast Feeding
It is unsafe to breastfeed while taking Pemejas 500mg Injection because it can cause toxicity to the baby. If you are breastfeeding a baby, it has to be discontinued. Please consult your physician for more advice.
Alcohol
It is unknown whether consuming alcohol while taking a Pemejas 500mg Injection is safe. Please speak with your physician.
Liver
Inform your physician about any underlying liver disorders before taking Pemejas 500mg Injection, as this medication should be used with caution in liver disease patients.
Lungs
Consult your doctor if you experience any symptoms like; shortness of breath, blockage, or inflammation in the lining of the lung while taking Pemejas 500mg Injection.
Driving
While taking Pemejas 500mg Injection, it is unsafe to drive or use machines because it may cause nausea, fatigue, vomiting, etc. Talk to your doctor for more information.
Pregnancy
Do not take Pemejas 500mg Injection if you are pregnant because it may cause harm to the unborn baby. Consult your doctor before starting the treatment.
Side Effects of Pemejas 500mg Injection
Side effects are unwanted symptoms caused by medicines. Even though all medicines cause side effects, not everyone gets them.
Serious:
- Blood infection
- Severe allergic reaction
- Breathlessness, intense chest pain or cough with bloody sputum
- Reduced neutrophil granulocytes (white blood cells)
- Kidney failure
- Pharyngitis (a sore throat)
- Abnormal liver function
Common:
- Fatigue
- Nausea, vomiting, diarrhoea
- Redness, swelling or sores in the mouth
- Loss of appetite, sensation
- Reduced haemoglobin level
- Increased skin pigmentation
- Watery and inflamed eyes, taste change
- Fever
- Muscle weakness
- Dehydration
- Constipation
- Skin rash
- Hair loss
Word of Advice
Discuss your fertility problem with the doctor since, in men. It is advised not to father a child during and after the 3 months of treatment. So, it is advised to get suggestions about fertility concerns. Avoid planning for the pregnancy. If you experience any symptoms mentioned as a side effect, consult your doctor immediately.
Notify your doctor immediately if you have undergone any radiotherapy or taken any vaccines and other medications before starting with Pemejas 500mg Injection because it might reduce the effectiveness of this medicine and may cause side effects. Inform your doctor if you have or have had any history of heart disease, kidney problems, or liver problems.
FAQs about Pemejas 500mg Injection
Q1.
What should I tell my doctor before starting Pemejas 500mg Injection?
Before starting Pemejas 500mg Injection, you should tell your doctor about any medical conditions you have, especially kidney or liver problems, as well as any medications you are taking, including over-the-counter drugs and supplements.
Q2.
Why do I feel nauseous while taking Pemejas 500mg Injection?
Nausea is a common side effect of chemotherapy drugs, including Pemejas 500mg Injection. This happens because chemotherapy drugs can affect the lining of the stomach, leading to nausea and vomiting.
Q3.
How is Pemejas 500mg Injection administered?
A healthcare provider gives Pemejas 500mg Injection as an intravenous (IV) injection. The dose and frequency of the injections will depend on the patient's condition and other factors.
Q4.
Can I continue my normal activities while on Pemejas 500mg Injection?
It depends on your circumstances and how you feel. You should discuss your activities and any concerns with your healthcare provider.
Q5.
How often do I need to have blood tests while on Pemejas 500mg Injection?
You will need to have regular blood tests while taking Pemejas 500mg Injection to monitor your blood cell counts, blood uric acid level, and kidney function.
Q6.
Can children or adults take Pemejas 500mg Injection?
No, Pemejas 500mg Injection is not recommended for children or adults under 18 years. Talk with your doctor for more information.
Fact Box of Pemejas 500mg Injection
Molecule name: Pemetrexed | Therapeutic class: Anti-Cancer |
Pharmacological class: Antifolate agent | Indication:
|
References
1. KD Tripathi, Essentials of Medical Pharmacology, Anticancer drugs,7th edition, 2013, 863.
2. Eagle Pharmaceuticals, US Food and Drug Administration, [ Revised on Feb 2020] [ Accessed on 27 - March - 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/209472s000lbl.pdf
3. Seacross Pharmaceuticals Ltd, Electronic medicines compendium (emc), [ Accessed on 27 - March - 2023], https://www.medicines.org.uk/emc/files/pil.8887.pdf
Disclaimer
MrMed’s primary intention is to ensure that its consumers get information that is reviewed by experts, accurate and trustworthy. The information and contents of this website are for informational purposes only. They are not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of your doctor and discuss all your queries related to any disease or medicine. Do not disregard professional medical advice or delay in seeking it because of something you have read on MrMed. Our mission is to support, not replace, the doctor-patient relationship.
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Author Details
Written By
Dr. Deva Prasath S.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 14 May 2026 | 06:20 AM (IST)
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