The uses of Pentanerv SR 450mg Tablet are:

• Neuropathic pain (e.g., postherpetic neuralgia in adults)
• Partial onset seizures (with and without secondary generalisation) in adults and pediatric patients aged 3 years and older with epilepsy
• Other forms of neuropathic pain
• Seizure management

Pentanerv SR 450mg Tablet binds strongly to the α2δ subunit of voltage-activated calcium channels, contributing to its pain-relieving and seizure-controlling effects, although the exact mechanism remains unclear.

It is important to inform your healthcare professional about all the medications you are taking, including prescription drugs, over-the-counter medications, nutritional supplements, and herbal products. Some medications may interact with Pentanerv SR 450mg Tablet, potentially affecting their effectiveness or causing side effects.

• Keep out of reach of children and pets.
• Store in the original packaging to protect from moisture.
• Avoid direct sunlight
• Store Pentanerv SR 450mg Tablet at room temperature.

For Pentanerv SR 450mg Tablet, treatment typically begins with a low dose, such as 300 mg on Day 1 for Postherpetic Neuralgia, with gradual increases over the following days. Dosing adjustments are made based on the patient's response and condition. In patients with reduced renal function, the dose of Pentanerv SR 450mg Tablet should be adjusted, regardless of the formulation. Consult your healthcare provider for personalised dosing recommendations and adjustments based on your specific condition and renal function.

Side effects are unwanted symptoms caused by medicines. Although all drugs can cause side effects, not everyone experiences them.

Common side effects of Pentanerv SR 450mg Tablet are:

• Dizziness
• Sleepiness (somnolence)
• Swelling (peripheral edema)
• Fatigue
• Nausea and vomiting
• Lack of coordination
• Diarrhea
• Dry mouth
• Constipation
• Weight gain
• Tremor
• Sore throat
• Double vision and blurred vision

Serious side effects of Pentanerv SR 450mg Tablet are:

• Jaundice (yellowing of the skin or eyes)
• Rhabdomyolysis (muscle breakdown)
• Liver problems (hepatobiliary disorders)
• Elevated creatine kinase and liver function tests
• Movement disorders

Discontinue Pentanerv SR 450mg Tablet immediately if you experience serious reactions such as DRESS, anaphylaxis, or angioedema, and contact your healthcare provider. Avoid driving or operating heavy machinery if you feel sleepy or dizzy. Do not stop taking Pentanerv SR 450mg Tablet abruptly, as it can increase your seizure risk. Monitor yourself for any suicidal thoughts or behaviours, particularly if you have epilepsy, and report any neuropsychiatric symptoms, especially in children. Always follow your healthcare provider's guidance and seek medical advice if you notice any concerning symptoms.

1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020235s064_020882s047_021129s046lbl.pdf

2. asaei R, Katta S, Patel P, Saadabadi A. Gabapentin. https://pubmed.ncbi.nlm.nih.gov/29630280/

3. Backonja M, Glanzman RL. Gabapentin dosing for neuropathic pain: evidence from randomized, placebo-controlled clinical trials. https://pubmed.ncbi.nlm.nih.gov/12637113/

4. https://www.ema.europa.eu/en/medicines/human/referrals/neurontin