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Pivikto 200mg+50mg Tablet
Last updated on 29 Jul 2026 | 10:27 AM (IST)
₹34000
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Introduction to Pivikto 200mg+50mg Tablet
Pivikto 200mg + 50mg tablet contains the active constituent Alpelisib. It is an anticancer agent that belongs to the class of medications called PI3K (phosphatidylinositol-3-kinase) inhibitors. It is used in combination with other anticancer medication to treat a certain type of breast cancer that has spread to nearby tissues or other parts of the body in women who have already gone through menopause or in men whose cancer got worse during or after certain other treatments. It is also used to treat those who have certain types of PIK3CA-related overgrowth spectrum (PROS; a genetic condition that causes overgrowth and abnormalities in certain body tissues).
Do not take Pivikto 200mg + 50mg if you are allergic to Alpelisib or other ingredients in the medicine. Inform your physician if you have high levels of sugar in your blood or diabetes, bone disease, symptoms of skin rash, blistering of the lips, eyes, or mouth, skin peeling, fever, and red skin. Report to your doctor if you face any symptoms of rash, itching, hives, breathlessness, shortness of breath, wheezing, cough, low blood pressure, or discoloration of lips, tongue, or skin. This medicine is not recommended to be used in children and in adolescents under 18 years of age.
Uses of Pivikto 200mg+50mg Tablet
- HER2- negative Breast cancer
Therapeutic Effects of Pivikto 200mg+50mg Tablet
Pivikto 200mg + 50mg is a kinase inhibitor of phosphatidylinositol-3-kinase (PI3K) with inhibitory activity predominantly against PI3K-alpha. In breast cancer cell cells, PI3K inhibition by this medicine induces an increase in estrogen receptor transcription. These enzymes help cancer cells to grow and multiply. By blocking their action, it can reduce cancer growth and spread and help destroy cancer cells.
Interaction of Pivikto 200mg+50mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Pivikto 200mg + 50mg and reduce its effectiveness by causing undesirable side effects.
More Information about Pivikto 200mg+50mg Tablet
- Store the Pivikto 200mg + 50mg at 20°C to 25°C
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you forgot to take the tablet, simply take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
How to consume Pivikto 200mg+50mg Tablet
Your doctor will decide the dose and duration of Pivikto 200mg + 50mg based on the disease condition and other factors. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, immediately after food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with water. If you cannot swallow the tablet, mix the tablets into a glass of water as per doctor advice.
Safety Advice for Pivikto 200mg+50mg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking Pivikto 200mg + 50mg because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Alcohol
It is not known whether it is safe to consume alcohol with Pivikto 200mg + 50mg. Please consult your doctor.
Liver
Pivikto 200mg + 50mg is safe to use in patients with liver problems. There is no need for dose adjustments. Inform your physician if you have any liver disease before initiating the therapy.
Lungs
It is unknown whether Pivikto 200mg + 50mg can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Pivikto 200mg + 50mg may alter your ability to drive and operate heavy machinery. The treatment may cause tiredness hence avoid activities after taking the medicine.
Pregnancy
Do not take Pivikto 200mg + 50mg if you are pregnant because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting pregnancy, or planning to get pregnant during the treatment. Use effective contraception during the treatment and for 1 week after the last dose.
Side Effects of Pivikto 200mg+50mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common
- Hair loss
- Decreased weight
- Decreased appetite
- Nausea, vomiting
- Tiredness
Serious
- Cellulitis
- Hyperglycemia
- Diarrhea
- Hypersensitivity reactions
- Pneumonitis
- Dehydration
- Angioedema
Word of Advice
Your doctor may give you medicines to prevent nausea and vomiting before the treatment. If you vomit after taking the tablet, take the next dose at the regular time. Women should use an effective form of birth control during treatment and for 1 week after the last dose. Male patients who have female partners should use effective birth control during treatment and for 1 week after the last dose. Tell your doctor if you have kidney disease, lung disease or breathing problems, or diabetes. Do not breastfeed during treatment with this medicine and for 1 week after the last dose. Your doctor may advise you to take certain blood tests during the treatment to monitor any unwanted side effects.
FAQs about Pivikto 200mg+50mg Tablet
Q1.
Can a patient with kidney problems take Pivikto 200mg + 50mg?
Pivikto 200mg + 50mg should be cautiously taken if you have any kidney problems. Dose adjustments are necessary for patients with kidney diseases. Inform your doctor if you are on dialysis and have any kidney disorders.
Q2.
What if I overdose or take two doses of Pivikto 200mg + 50mg?
If you unknowingly overdosed or took two doses of Pivikto 200mg + 50mg, immediately inform your healthcare professional and seek medical advice.
Q3.
Should Pivikto 200mg + 50mg be taken with or without food?
Pivikto 200mg + 50mg comes as a tablet to take by mouth. It is usually taken immediately after the food. Take the tablets as prescribed by your doctor.
Q4.
Does Pivikto 200mg + 50mg cause hair loss?
Thinning or loss of your hair will usually start within two to four weeks of your first dose of Pivikto 200mg + 50mg. You may also have thinning or loss of eyelashes, eyebrows, and other body hair. Consult your doctor if you have excessive hair loss.
Q5.
Does Pivikto 200mg + 50mg cause an increase in sugar levels?
Pivikto 200mg + 50mg is intended to cause hyperglycemia because it blocks the intracellular action of insulin systemically. This mechanism of action creates a transient state of insulin resistance and hyperglycemia, a common adverse event observed.
Fact Box of Pivikto 200mg+50mg Tablet
Molecule name: Alpelisib
| Therapeutic class: Antineoplastics |
Pharmacological class: PI3K Inhibitors
| Indications: Breast Cancer |
References
Piqray 200 mg film-coated tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Revised September 2022. Accessed April 28, 2023. https://www.medicines.org.uk/emc/product/11684/smpc
Piqray - alpelisib; Revised on 2019. Accessed April 28, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/212526s000lbl.pdf
Kui-Jin Kim, et al., PI3K-targeting strategy using alpelisib to enhance the antitumor effect of paclitaxel in human gastric cancer, Scientific Reports, Jul 2020, [Accessed April 28, 2023] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378194/
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 29 Jul 2026 | 10:27 AM (IST)
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