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PRO-THROM 250IU INJECTION_1
PRO-THROM 250IU INJECTION_2
PRO-THROM 250IU INJECTION_1
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Pro-Throm 250IU Injection

Prescription Required

cold-chain

Salt Composition : Human Prothrombin Complex

Manufacturer : INTAS PHARMACEUTICALS LTD

Origin of Medicine : India

MRP: 20810.46
Price :15544
You Save :5266 (25%)

1 Vial(s)

Prepaid Only. Non-Returnable


Introduction to Pro-throm 250iu Injection

Pro-throm 250IU injection is a hemostatic that belongs to the group of medicines called clotting factors. It contains the human prothrombin complex, which is composed of vitamin K-dependent blood coagulation factors II, VII, IX, and X. It is used to treat and prevent acute major bleeding caused by certain medicines called vitamin K antagonists (warfarin). It is also indicated in people born with low levels of vitamin K-dependent coagulation factors II and X.  It is used when a purified specific clotting factor product is unavailable. 

Do not take Pro-throm 250IU injection if you are allergic to heparin and any one of the ingredients in the medicine. Inform your physician if you have IgA (immunoglobulin A) deficiency with known antibodies against IgA. Tell your physician if you have a history of heart problems, liver diseases or if you are going to have any surgery before initiating the treatment.  This medicine may increase your risk of thrombosis (blood clots); notify your physician immediately if you face any signs and symptoms of thrombosis, such as limb or abdomen swelling or pain, chest pain, drop in blood pressure, shortness of breath, loss of sensation or motor power, altered consciousness, vision or speech disturbances, confusion, and fever. 

Limited information is available regarding the use of Pro-throm 250IU injection in children and adolescents. The most common side effects are headache, nausea, vomiting, decreased blood pressure, and anemia. Human prothrombin complex is made from human blood; hence it may carry a risk of transmitting infectious agents. Discuss the risks and benefits with your doctor before receiving this medicine


Uses of Pro-throm 250iu Injection

  • Treat and prevent bleeding.

Therapeutic Effects of Pro-throm 250iu Injection

Human prothrombin complex contains vitamin K-dependent coagulation factors II, VII, IX, and X, together known as prothrombin complex and antithrombotic protein C and protein S. The clotting factors in this medicine affect the coagulation cascade at various steps. It also increases plasma levels of the vitamin K-dependent coagulation factors and can temporarily correct the coagulation defect of patients with a deficiency of one or several of these factors. 


Interaction of Pro-throm 250iu Injection with other drugs

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Pro-throm 250IU injection and reduce its effectiveness by causing undesirable side effects


More Information about Pro-throm 250iu Injection

  • Do not store it above 25°C
  • Protect the medicine from excessive moisture, and direct light
  • keep the injection away from the reach of children and pets.
  • If you have missed any dosing appointments, inform your doctor and schedule immediately.

How to consume Pro-throm 250iu Injection

A doctor or nurse in a hospital or clinic setting will give it to you. Your doctor will decide the dose and for how long you will receive this injection based on the severity of your illness, bleeding area, and general condition. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection.


Safety Advices for Pro-throm 250iu Injection

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Pregnancy

  

Limited information is available on the use of Pro-throm 250IU injection during pregnancy. Your physician will suggest whether you can receive this injection during pregnancy. Hence, inform your doctor or other healthcare provider if you are pregnant, suspecting or planning for pregnancy. 

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Breast Feeding

  

Limited information is available on the use of Pro-throm 250IU injection during breastfeeding. Your physician will suggest whether you can receive this injection during breastfeeding. Hence, inform your doctor or other healthcare provider if you are breastfeeding. 

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Lungs

  

It is unknown whether Pro-throm 250IU injection can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.

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Liver

  

It is unknown whether Pro-throm 250IU injection can be used in patients with liver disorders. Consult your doctor if you have any liver problems before starting the treatment.

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Alcohol

  

It is unknown whether consuming alcohol is safe during the treatment with Pro-throm 250IU injection. Inform your doctor if you are a chronic drinker.

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Driving

  

It is not known whether  Pro-throm 250IU injection can cause dizziness. Consult your doctor for more advice


Side Effects of Pro-throm 250iu Injection

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

  • Decreased blood pressure
  • Nausea
  • Vomiting
  • Muscle and bone pain
  • Headache

Serious

  • Bleeding
  • Blood clots
  • Skin hypersensitivity reaction
  • Lung infection

Word of Advice

Make sure your doctor knows if you have had a stroke, heart attack, deep vein thrombosis (DVT), or any other heart or blood clot problem in the last 3 months. This medicine may increase your risk of blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, trouble breathing or swallowing, swelling or tenderness in your leg, or numbness or weakness. This medicine is made from donated human blood. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you are concerned about this risk.


FAQs

Q 1. How is Pro-throm 250IU injection for urgent warfarin reversal administered?

A doctor or nurse in a hospital or clinic setting will give it to you. Your doctor will decide the dose and for how long you will receive this injection based on the severity of your illness, bleeding area, and general condition. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection.

Q 2. Why must vitamin K be used with Pro-throm 250IU injection?

Administer vitamin K concurrently to patients receiving Pro-throm 250IU injection. Vitamin K is administered to maintain vitamin K–dependent clotting factor levels once the effects of Pro-throm 250IU injection have diminished.

Q 3. Is Pro-throm 250IU injection made from human blood?

Pro-throm 250IU injection is produced from human blood plasma. It undergoes a rigorous purification and viral inactivation process to assure its safety and effectiveness.

Q 4. Will Pro-throm 250IU injection transmit the infectious virus?

A multistep pathogen inactivation and elimination method, comprising heat treatment and viral filtering, is used to limit the danger of infectious agent transmission. There is no way to totally eliminate the possibility of virus transmission.

Q 5. What is Pro-throm 250IU injection composed of?

It is a balanced concentrate with a specific concentration of the four vitamin K-dependent clotting factors (II, VII, IX, and X) as well as the thrombo-inhibitor proteins C and S.


Fact Box of Pro-throm 250iu Injection

Molecule name: Human Prothrombin Complex 

Therapeutic class: Immunosuppressants 

Pharmacological class: Hemostatistics

Indications: Treat and prevent bleeding 


References

  1. Octaplex 500 IU - Summary of Product Characteristics (SmPC) - (Emc).” Medicines.org.uk, Revised Mar. 2020, www.medicines.org.uk/emc/product/6566/smpc.  Accessed 24 May 2023.
  2. Prothrombin Complex Concentrate (Human), Kcentra .; Revised 2020. Accessed May 24, 2023. https://www.fda.gov/media/85512/download
  3. Q.M. Anstee, D.E.J. Jones, Liver and biliary tract disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 921-988.

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