• Treat and prevent bleeding.

Human prothrombin complex contains vitamin K-dependent coagulation factors II, VII, IX, and X, together known as prothrombin complex and antithrombotic protein C and protein S. The clotting factors in this medicine affect the coagulation cascade at various steps. It also increases plasma levels of the vitamin K-dependent coagulation factors and can temporarily correct the coagulation defect of patients with a deficiency of one or several of these factors. 

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Pro-throm 250IU injection and reduce its effectiveness by causing undesirable side effects

• Do not store it above 25°C
• Protect the medicine from excessive moisture, and direct light
• keep the injection away from the reach of children and pets.
• If you have missed any dosing appointments, inform your doctor and schedule immediately.

A doctor or nurse in a hospital or clinic setting will give it to you. Your doctor will decide the dose and for how long you will receive this injection based on the severity of your illness, bleeding area, and general condition. It is given as an intravenous infusion drip (into your vein). Do not self-administer the injection.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

• Decreased blood pressure
• Nausea
• Vomiting
• Muscle and bone pain
• Headache

Serious

• Bleeding
• Blood clots
• Skin hypersensitivity reaction
• Lung infection

Make sure your doctor knows if you have had a stroke, heart attack, deep vein thrombosis (DVT), or any other heart or blood clot problem in the last 3 months. This medicine may increase your risk of blood clots. Tell your doctor right away if you have a sudden or severe headache, problems with vision or speech, chest pain, trouble breathing or swallowing, swelling or tenderness in your leg, or numbness or weakness. This medicine is made from donated human blood. Some human blood products have transmitted viruses to people who have received them, although the risk is low. Human donors and donated blood are both tested for viruses to keep the transmission risk low. Talk with your doctor if you are concerned about this risk.

1. Octaplex 500 IU - Summary of Product Characteristics (SmPC) - (Emc).” Medicines.org.uk, Revised Mar. 2020, www.medicines.org.uk/emc/product/6566/smpc.  Accessed 24 May 2023.
2. Prothrombin Complex Concentrate (Human), Kcentra .; Revised 2020. Accessed May 24, 2023. https://www.fda.gov/media/85512/download
3. Q.M. Anstee, D.E.J. Jones, Liver and biliary tract disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 921-988.