PRO-THROM 250IU INJECTION

Introduction:

Pro-Throm 250IU Injection consists of the active ingredient Human Prothrombin Complex. It is used to prevent and treat bleeding caused by deficiency of vitamin K-dependent clotting factors II and X. 

It also treats bleeding that is likely to occur in patients taking medicines that block vitamin K activity (Warfarin etc.). It belongs to the category of medications called clotting factors that contain vitamin K-dependent blood clotting factors II, VII, IX and X. This medicine is only prescribed to fix the shortage in events like major bleeding or emergency surgery.

With the aid of Vitamin K, the liver synthesizes the clotting factors II, VII, IX, X, commonly referred to as the prothrombin complex. If one of these factors is deficient, the blood clotting mechanism damages the extent of requiring a substitution therapy. Clotting factor deficiency is an essential indicator of how the liver is working.

Uses of Pro-Throm 250IU Injection:

• Prevention and treatment of bleeding.

How Pro-Throm 250IU Injection works:

Pro-Throm 250IU Injection increases the plasma levels of the vitamin K-dependent clotting factors and temporarily corrects the clotting defect caused by the deficiency of one of these factors.

Interaction with other drugs:

Inform your doctor about any medications you are taking or have taken before the treatment.

More Information:

Do not store above 25°C. Do not freeze. keep out of the reach of children.

References:

1. Octapharma Limited, Electronic Medicines Compendium (EMC), [Revised on Mar 2020] [Accessed on 19th Jul 2021], https://www.medicines.org.uk/emc/files/pil.6566.pdf 
2. Octapharma Pharmazeutika Produktionsges m.b.H., [Revised on 24th Oct 2017] [Accessed on 19th Jul 2021], https://a.storyblok.com/f/54881/x/8468f1f57c/octaplex-pm-en.pdf 
3. Q.M. Anstee, D.E.J. Jones, Liver and biliary tract disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 921-988. 

How to use Pro-Throm 250IU Injection:

This injection should be used only under the supervision of a physician specialized in clotting disorders. Your physician will determine the dose depending on the severity of illness, site of bleeding and your general condition.

Safety Advice:

Pregnancy:

Inform your physician before starting this treatment if you are pregnant or think you might be pregnant. Your physician will recommend this medicine only if it is clearly essential.

Breastfeeding: 

Consult your physician for advice before taking this medicine if you are breastfeeding your child. Your physician will recommend this medicine only if it is clearly essential.

Liver:

Inform your physician before starting this treatment if you have liver diseases. Ensure that you have taken vaccines for Hepatitis A and Hepatitis B.

Kidney:

Inform your physician before starting this treatment if you have kidney diseases. 

Others:

• Inform your physician before taking this medicine if you have heart problems, vitamin K deficiency or have been diagnosed with IgA deficiency.
• Consult your physician who is specialized in clotting disorders in case of any doubts.
• Inform your physician if you experience allergic reactions to Human Prothrombin Complex or other ingredients of this medicine.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Clots in blood vessels
• Allergic reactions
• Heart disorders
• Low or high BP
• Breathlessness

Common:

• Headache
• Injection site burning sensation
• Liver problems
• Tremor
• Fever, chills
• Nausea
• Rashes