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Puregraf 300IU Injection PFS
Last updated on 31 Mar 2026 | 09:29 AM (IST)
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Puregraf 300IU Injection PFS
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MENOTROPHINMarketer
GUFIC BIOSCIENCE LTD
Prepaid Only. Non-Returnable.
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₹1864
MRP: ₹4,658.50
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MENOTROPHINMarketer
GUFIC BIOSCIENCE LTD
Prepaid Only. Non-Returnable.
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Introduction to Puregraf 300IU Injection PFS
Puregraf 300IU Injection PFS contains the active substance Menotrophin. It is an ovulation stimulator that belongs to the group of medications called gonadotropins. It is a highly purified mixture of follicle-stimulating hormone (FSH) and luteinising hormone (LH). They are natural hormones produced in both males and females. They help the reproductive organs to work normally.
Puregraf 300IU Injection PFS is used to treat infertility in women who are not ovulating, including those with polycystic ovarian disease, and who have not responded to treatment with another medicine called clomiphene citrate. It is also used to help multiple follicles and, therefore, to promote fertility in women undergoing IVF (in-vitro fertilisation) or other types of assisted conception. It is also indicated to treat infertility in men due to low sperm count.
Do not take Puregraf 300IU Injection PFS if you are allergic to menotrophin or any of the other ingredients of this medicine. Do not take this medicine if you have a tumour in the pituitary gland (a gland located on the base of the brain which produces certain hormones, including growth hormones) or in the hypothalamus (an area located under the part of the brain called the thalamus which controls the conditions within your body including body temperature and blood pressure) or in the uterus, ovaries, breast, testicles, or in the prostate gland. Before initiating the treatment, you will be checked for underactive thyroid problems, hormone levels, and tumours of the pituitary and hypothalamus.
Do not take this medicine if you have ovarian cysts that are not due to PCOD, vaginal bleeding, early menopause, physical problems in the reproductive organs if your womb has been removed, and if you are pregnant or breastfeeding. Inform your physician immediately if you face any of these symptoms, such as abdominal pain and swelling, weight gain, diarrhoea, difficulty in breathing, and decreased urination. Inform your physician if you have or have had a liver problem or a history of blood clotting disease before starting the treatment.
Uses of Puregraf 300IU Injection PFS
- Infertility in men and women
Therapeutic Effects of Puregraf 300IU Injection PFS
In the absence of sufficient endogenous luteinising hormone (LH), menotrophin binds to the follicle-stimulating hormone receptor (FSH), resulting in ovulation. It also attaches to the LH receptor, causing appropriate hormone release and treating infertility in women and men.
Interaction of Puregraf 300IU Injection PFS with other drugs
Inform your healthcare provider about all the medicines that you take, including prescription, over-the-counter, recent vaccinations, nutritional and vitamin supplements, and herbal products. Certain medications may interact with Puregraf 300IU Injection PFS and reduce its effectiveness by causing undesirable side effects.
More Information about Puregraf 300IU Injection PFS
- Do not store above 25°C
- Do not freeze
- keep the injection away from the reach of children and pets.
How to consume Puregraf 300IU Injection PFS
It will be given to you by a doctor or nurse in a hospital or clinic setting. It is given as an intramuscular injection (into your muscles) or under the skin. Do not self-administer the injection. Your doctor will decide the dose, route of administration and duration of the treatment based on your disease severity, body weight, and other factors.
Safety Advice for Puregraf 300IU Injection PFS
Breast Feeding
Breastfeeding is not recommended in patients taking Puregraf 300IU Injection PFS because the medicine passes into the breast milk in small amounts and may harm your baby.
Alcohol
It is unknown whether consuming alcohol is safe during the treatment with Puregraf 300IU Injection PFS. Inform your doctor if you are a chronic drinker.
Liver
It is unknown whether Puregraf 300IU Injection PFS can be used in patients with liver disorders. Consult your doctor if you have any liver problems before starting the treatment.
Lungs
It is unknown whether Puregraf 300IU Injection PFS can be used in patients with lung disorders. Consult your doctor if you have any lung diseases before starting the treatment.
Driving
Puregraf 300IU Injection PFS does not affect the ability to drive. If you feel tired or dizzy after taking this medicine, do not drive and consult your doctor for more advice
Pregnancy
Puregraf 300IU Injection PFS is unsafe to administer in pregnant women because it may affect the fetus. Inform your physician if you are pregnant, suspect pregnancy, or planning to become pregnant.
Side Effects of Puregraf 300IU Injection PFS
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Common side effects of Puregraf 300IU Injection PFS are:
- Abdominal pain or swelling
- Headache
- Nausea
- Pelvic pain
- Overstimulation of ovaries
- Pain or inflammation at the injection site
- Mood swings
Serious side effects of Puregraf 300IU Injection PFS are:
- Severe allergic reactions (hypersensitivity reactions)
Word of Advice
If you have missed any dosing appointments, inform your doctor and schedule immediately. This medicine can increase your risk of ectopic pregnancy (pregnancy outside of the womb) if you have a history of fallopian tube disease, miscarriage, multiple pregnancies (twins and triplets), and birth defects in the baby. Your doctor will regularly perform ultrasound scans and blood tests to monitor your response to the treatment.
FAQs about Puregraf 300IU Injection PFS
Q1.
What is the purpose of using Puregraf 300IU Injection PFS in fertility treatments?
Puregraf 300IU Injection PFS is used in fertility treatments to help multiple follicles and stimulate the ovaries in women who are undergoing assisted reproductive technologies such as in vitro fertilisation (IVF) or intrauterine insemination (IUI). It helps promote the growth, maturation, and release of eggs from the ovaries in women who are not ovulating, including those with PCOD, and who have not responded to treatment with another medicine called clomiphene citrate.
Q2.
What are the possible side effects of Puregraf 300IU Injection PFS?
Common side effects of Puregraf 300IU Injection PFS may include injection site reactions, abdominal discomfort, bloating, breast tenderness, headache, and mood swings. However, individual responses may vary, and it is important to discuss any concerns or unexpected side effects with a healthcare professional.
Q3.
Can Puregraf 300IU Injection PFS be used in men for fertility treatment?
Puregraf 300IU Injection PFS is primarily used in women to stimulate ovulation and promote fertility. It is also used to treat infertility in men due to low sperm count. If you have concerns about male fertility, it is recommended to consult with a healthcare professional for appropriate evaluation and guidance.
Q4.
Can Puregraf 300IU Injection PFS increase the chances of multiple pregnancies?
Yes, the use of Puregraf 300IU Injection PFS in fertility treatments can increase the chances of multiple pregnancies, including twins, triplets, or higher-order multiples. This is due to the stimulation of multiple follicles and the potential release of multiple eggs. The risk of multiple pregnancies is a consideration that healthcare providers take into account when determining the dosage and monitoring the treatment.
Q5.
What is the source of Puregraf 300IU Injection PFS?
Puregraf 300IU Injection PFS is a highly purified mixture of two hormones called follicle-stimulating hormone (FSH) and luteinising hormone (LH). FSH and LH are natural hormones produced in both males and females. They help the reproductive organs to work normally.
Fact Box of Puregraf 300IU Injection PFS
Molecule name: Menotrophin
| Therapeutic class: Fertility Agent |
| Pharmacological class: Gonadotropins | Indications: Infertility in men and women |
References
- Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, Introduction to endocrinology: The hypothalamic-pituitary axis, 12th edition, 2011, 1123.
- KD Tripathi, Essentials of Medical Pharmacology, Anterior pituitary hormonses, 7th edition, 2013, 241.
- Ferring Pharmaceuticals Ltd, Electronic medicines compendium (emc), [Revised on August 2019] [ Accessed on June 2023], https://www.medicines.org.uk/emc/files/pil.1294.pdf
- Ferring Pharmaceuticals, US Food and Drug Administration, [Revised on Feb 2014] [ Accessed on June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/021663s014lbl.pdf
Disclaimer
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Author Details
Written By
Dr. Vijayalakshmi N.
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:29 AM (IST)
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