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Pyrimethamine 25mg Tablet
Last updated on 26 Sep 2026 | 08:43 AM (IST)
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Introduction to Pyrimethamine 25mg Tablet
Pyrimethamine 25mg Tablet contains the active ingredient Pyrimethamine. It is an antiparasitic drug that belongs to a group of medicines called antiprotozoals. It is used in combination with other antibiotics to treat blood infections caused by a parasite called toxoplasma. These infections can affect the brain and other parts of the body if your immune system is poor. This can be caused due to AIDS or HIV infection. It is also used to treat malarial infections.
Do not take Pyrimethamine 25mg Tablet if you are allergic to pyrimethamine or any of the other ingredients or if you are pregnant or breastfeeding. This tablet is not recommended in children under five years of age. Inform your physician if you have kidney or liver problems, anemia, and seizures. This medicine will always be given to you with a vitamin supplement. Do not forget to take your vitamin supplements.
Uses of Pyrimethamine 25mg Tablet
- Toxoplasmosis
- Acute malaria
Therapeutic Effects of Pyrimethamine 25mg Tablet
Pyrimethamine 25mg Tablet binds to and reversibly inhibits the protozoal enzyme and selectively blocks its conversion, which is essential for DNA synthesis and cell proliferation.
Interaction of Pyrimethamine 25mg Tablet with other drugs
Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional and vitamin supplements, and herbal products. Certain medications interact with Pyrimethamine 25mg Tablet and reduce its effectiveness by causing undesirable side effects.
More Information about Pyrimethamine 25mg Tablet
- Store Pyrimethamine 25mg Tablet below 30°C
- Protect the medicine from light and excessive moisture.
- Keep the medicine out of reach of children and pets
- If you forgot to take the tablet, take your next dose at the scheduled time. Do not take a double dose to make up for a forgotten dose.
How to consume Pyrimethamine 25mg Tablet
It is an orally available prescription drug. Your doctor will decide the dose and duration of Pyrimethamine 25mg Tablet based on the disease condition and other factors such as body weight and age. Always take this medicine as prescribed by your doctor. Take the tablet at the same time, with or without food. Do not break, chew, crush, or break the tablet. Swallow the whole tablet with a glass of water.
Safety Advice for Pyrimethamine 25mg Tablet
Breast Feeding
Breastfeeding is not recommended in patients taking Pyrimethamine 25mg Tablet because the medicine passes into the breast milk in small amounts and may harm your baby. Do not breastfeed during the treatment.
Alcohol
It is unsafe to drink alcohol while taking Pyrimethamine 25mg Tablet. It may reduce the effectiveness of the drug and can cause toxic side effects.
Liver
Pyrimethamine 25mg Tablet should be cautiously administered in patients with liver diseases. Dose adjustments are necessary. However, inform your physician if you have any liver diseases before initating the therapy.
Lungs
It is unknown whether Pyrimethamine 25mg Tablet is safe to be administer in patients with lung diseases. Inform your physician if you have any lung diseases before initiating the therapy.
Driving
Limited studies are available on the effects of Pyrimethamine 25mg Tablet on driving and ability. Dizziness and seizures have been reported by the patients. Howevere, if you experience these, inform your physician and seek medical advice.
Pregnancy
Do not take Pyrimethamine 25mg Tablet if you are in your first trimester because this may harm the unborn baby. Inform your physician if you are pregnant, suspecting, or planning to get pregnant during the treatment.
Side Effects of Pyrimethamine 25mg Tablet
Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.
Serious
- Severe skin reactions
- Low platelet counts
Common
- Skin rash
Word of Advice
Take all of the medicine and complete the course of therapy even if you feel better after the first few doses. Do not take extra dose or medicine to make up for a missed dose. Inform your doctor if you drink alcohol. This medicine may make you bleed, bruise, or catch infections more easily. Take precautions to prevent the illness.
Take this medicine as prescribed by your doctor. Take this medicine with food to decrease nausea and vomiting. Do not skip the medicine or change the dose without consulting the doctor. Common side effects like nausea, vomiting, and loss of appetite.
FAQs about Pyrimethamine 25mg Tablet
Q1.
What are the storage conditions for Pyrimethamine 25mg Tablet?
Store the Pyrimethamine 25mg Tablet below 30 degrees C. store it in the original cartoon. Prevent it from excessive moisture and light.
Q2.
Can Pyrimethamine 25mg Tablet be given to kidney disease patients?
Pryrimethamine should be given cautiously in patients with kidney diseases. Inform your physician if you have any kidney problems before initiating the therapy.
Q3.
What are the things i should inform my doctor before taking Pyrimethamine 25mg Tablet?
Inform your doctor if you have liver, or kidney diseases, anemia, history of seizures before initiating the treatment with Pyrimethamine 25mg Tablet.
Q4.
Why vitamin supplement (folic acid) is given with Pyrimethamine 25mg Tablet?
Pyrimethamine 25mg Tablet is an antagonist of folic acid. It inhibits the enzyme and reduces the activity. Hence, the supplement is given along with this medicine.
Q5.
Does Pyrimethamine 25mg Tablet cause iron deficiency?
Since, Pyrimethamine 25mg Tablet is an folic acid inhibitor it can cause anemia. You will be prescribed with vitamin supplements to maintain your hemoglobin levels.
Fact Box of Pyrimethamine 25mg Tablet
Molecule name: Pyrimethamine | Therapeutic class: Anti-parasitics |
Pharmacological class: Anti-protozoal | Indications: 1. Toxoplasmosis 2. Acute Malaria |
References
- Daraprim Tablets - Summary of Product Characteristics (SmPC) - (emc). www.medicines.org.uk. Published February 2023. Accessed May 9, 2023. http://www.medicines.org.uk/emc/product/938/smpc
- DARAPRIM ® (Pyrimethamine) 25-Mg Scored Tablets. Accessed May 9, 2023. https://www.accessdata.fda.gov/drugsatfda_docs/label/2003/08578slr016_daraprim_lbl.pdf
- Philip J. Rosenthal, Antiprotozoal Drugs, Lange’s Basic and Clinical Pharmacology, 14th Edition, 2018, 917-937.
- D.H. Dockrell, S. Sundar, B.J. Angus, R.P. Hobson, Infectious disease, Davidson’s Principles and Practice of Medicine, 22nd Edition, 2014, 293-386.
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Author Details
Written By
Dr. Karpagam A.
Pharm D
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 26 Sep 2026 | 08:43 AM (IST)
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