Ramiven 50mg Tablet is an anticancer medication containing the active ingredient Abemaciclib. It is used to treat certain types of breast cancer (hormone receptor-positive, HER2 negative breast cancer) that are advanced or metastatic (breast cancer that has spread to other parts of the body). Cancer is a condition in which cells multiply in an uncontrolled and abnormal manner. This medication works by inhibiting the proteins called cyclin-dependent kinases that play a significant role in the rapid multiplication of cancer cells. This medicine is intended for oral use only and it is given in combination with other hormonal medications.Ramiven 50mg Tablet is not recommended for adolescents and children under 18 years of age. Before taking this medicine, it is vital to inform your doctor if you have any signs of infections (fever, chills, or sore throat), liver or kidney disorders. 

Consult your doctor if you are pregnant or planning for pregnancy in the near future as Ramiven 50mg Tablet may impact your fetus. If you are in getting this treatment during the childbearing age, discuss with your doctor regarding the use of effective birth control methods during the treatment and for at least three weeks after the last dose. This medicine may cause fertility problems in men. You must not eat grapefruits or drink grapefruit juice during the treatment with Ramiven 50mg Tablet. Inform your physician of all the medicines, including supplements and herbal medicines, you are taking before you start treatment with this medication to avoid serious side effects. Report to your doctor if you have had a history of intolerance to any forms of sugar.

• Advanced or metastatic breast cancer.
• Advanced or metastatic non-small cell lung cancer.
• Advanced or metastatic endometrial cancer.
• Paediatric patients with neuroblastoma.

Ramiven 50mg Tablet works by blocking the activity of CDK4 and CDK6 enzymes, which are involved in cell division and growth. By inhibiting these enzymes, Ramiven 50 mg Tablet slows down or stops the growth of cancer cells.

Inform your healthcare provider about all the medicines you take, including prescription medications, over-the-counter medications, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Ramiven 50mg Tablet and reduce effectiveness by causing undesirable side effects. 

• Ramiven 50mg Tablet tablets should be stored at room temperature between 20°C and 25°C (68°F and 77°F).
• It should be kept dry and protected from light and moisture.
• The tablets should be kept in the original container with the cap tightly closed..
• Keep it out of reach from children and pets.
• It is important to get the dose at the scheduled time. If you missed the schedule, contact your doctor and reschedule the dose.

Ramiven 50mg Tablet is usually taken orally, with or without food. The tablets should be swallowed whole with a glass of water and not crushed, chewed or broken. The dosage and frequency will depend on various factors, including the patient's age, weight, overall health, and the type and stage of cancer being treated. It's important to follow the dosing instructions provided by a healthcare provider, and not to adjust the dosage or frequency without consulting with them first. If a dose is missed, it should be taken as soon as possible unless it's within 6 hours of the next scheduled dose. In that case, the missed dose should be skipped and the regular dosing schedule resumed. It's important not to take a double dose to make up for a missed dose.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Serious:

• Dehydration
• Kidney problem
• Electrolyte imbalances
• Liver damage
• Dark urine
• Abdominal pain
• Pneumonitis
• Interstitial lung disease
• Chest pain

Common:

• Diarrhoea
• Nausea
• Vomiting
• Fatigue
• Decreased appetite
• Abdominal pain
• Headache
• Respiratory tract infections
• Anaemia
• Increased risk of infections
• Low white blood cell count
• Low platelet count

If you have prescribed Ramiven 50mg Tablet or any other medication, it is important to follow the instructions provided by your healthcare provider and to report any side effects or concerns promptly. It can cause serious side effects, so it is important to monitor your symptoms and seek medical attention if you experience any concerning changes in your health. It is also important to avoid alcohol and to follow any safety recommendations provided by your healthcare provider while taking it. Remember to attend all scheduled appointments and follow-up visits with your healthcare provider to ensure your treatment is effective and any side effects are managed appropriately. With proper monitoring and management, it can be an effective treatment option for certain types of cancer.

1. Eli Lilly Nederland BV, Electronic medicines compendium (emc), [Revised on May 2022] [ Accessed on 29 March 2023], https://www.medicines.org.uk/emc/files/pil.11046.pdf

2. Lilly USA, US Food and Drug Administration, [Revised on October 2021] [Accessed on 29 March2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/208716s006s007s008lbl.pdf

3. DeVita, Hellman, and Rosenberg's Cancer: Principles & Practice of Oncology Authors,11th Edition, 2018, 1006-1022

4. Bruce A. Chabner, Dan L. Longo, Cancer Chemotherapy and Biotherapy: Principles and Practice, Edition: 6th, 2019, 501-502