Ranizurel 0.3mg Injection, contains the active ingredient Ranibizumab. It is an anti-neovascularisation agent in the class of medications called vascular endothelial growth factor A (VEGF-A) antagonists. It is used in adults to treat several eye diseases causing vision impairment. It is used to treat wet age-related macular degeneration (AMD, a persistent eye disease that causes loss of the ability to see straight ahead and may make it more difficult to read, drive, or perform other daily activities).

Ranizurel 0.3mg Injection is also used to treat myopic choroidal neovascularization (mCNV; a complication in near-sighted people where new blood vessels can grow in the back of the eye), and to treat macular edema after retinal vein occlusion (an eye disease caused by blockage of blood flow from the eye that leads to blurry vision and vision loss). It is also used to treat diabetic macular edema (an eye disease caused by diabetes that can lead to vision loss) and diabetic retinopathy (damage to the eyes caused by diabetes).

Do not use Ranizurel 0.3mg Injection if you are allergic to Ranibizumab or other ingredients of this medicine. Do not take this medicine if you have an infection in or around your eye and if you have pain or redness in your eye. Inform your doctor immediately if you develop symptoms such as eye pain or increased discomfort, worsening eye redness, blurred or decreased vision, an increased number of small particles in your vision, or increased sensitivity to light. Inform your doctor if you have a prior history of eye conditions or eye treatments or had a stroke before initiating the treatment.

Ranizurel 0.3mg Injection is used to treat several eye diseases causing vision impairment, including,

• Age-related macular degeneration

• Macular edema

• Diabetic macular edema and retinopathy

• Myopic choroidal neovascularization

• Retinal vein occlusion

Ranizurel 0.3mg Injection specifically recognizes and binds to a protein called human vascular endothelial growth factor A (VEGF-A) present in the eye. In excess, VEGF-A causes abnormal blood vessel growth and swelling in the eye, leading to impairment of vision in certain eye diseases. This medicine can block its actions and prevent this abnormal growth and swelling. This injection can help to stabilize and improve your vision.

Inform your healthcare provider about all the medicines you take, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications interact with Ranizurel 0.3mg Injection and reduce their effectiveness by causing undesirable side effects.

• Store in a refrigerator (2°C – 8°C)

• Do not freeze

• Protect the medicine from light and excessive moisture.

• Keep the medicine out of reach of children and pets.

Ranizurel 0.3mg Injection is administered as an injection into your eye by an eye doctor under a local anesthetic. Your doctor will decide the dose and frequency of the injection based on your disease condition. Do not self-administer the medicine.

Side effects are unwanted symptoms caused by medicines. Even though all drugs cause side effects, not everyone gets them.

Common

• Pain and swelling in the eye

• Bleeding in the eye

• Blurred vision

• Urinary tract infection

• Skin rashes

• Discharge from the eye

Serious

• Tear of the layer in the back of the eye

• Flashes of light in the eye

• Temporary loss of sight

• Clouding of lens

• Infection of the eyeball

• Not recommended for children or teens – Ranizurel 0.3mg Injection should not be used in individuals below 18 years of age due to a lack of safety data.

• Elderly patients may need dose adjustments – People over 65 can use this injection but may require modified doses based on their health condition.

• Seek immediate help for eye symptoms – If your eye becomes red, painful, sensitive to light, or if your vision changes, consult an eye doctor right away.

• Follow-up is important – Your doctor will monitor your eye and decide if further injections are needed based on how well you're responding.

• Stick to your doctor’s advice – Do not skip or delay your injections. Follow all medical instructions carefully for the best outcome.