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Screen for hepatitis B (HBV) before starting treatment and closely monitor liver function and HBV DNA levels during and after treatment, especially in those with current or past HBV infection.
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Inform your doctor about all current medications, as potential drug interactions need careful evaluation, especially with amiodarone, which can cause severe bradycardia.
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Dose adjustments are required for patients with severe kidney problems or end-stage renal disease, and psychiatric health should be monitored in those with a history of mental health disorders.
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Discuss pregnancy, breastfeeding, and special conditions (like HIV/HCV co-infection or liver transplant) with your doctor to ensure safe treatment.
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Quick Summary
Resof Total Tablet
Written By:Dr. Archana GuptaBDS Reviewed By:Dr. Tejashwin AdigaMBBS
Last updated on 31 Mar 2026 | 09:30 AM (IST)
₹5414
MRP: ₹19851.56
(You Save ₹14437.56)
28 TABLET(s) IN A BOTTLE
Resof Total Tablet is a prescription antiretroviral medicine used in the treatment of HIV (Human Immunodeficiency Virus) infection in adults. It is a fixed-dose combination of antiviral agents that work by preventing the virus from multiplying in the body, helping to reduce viral load and improve immune system function. Resof Total is used under medical supervision as part of a long-term HIV treatment regimen.
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Introduction
Resof total tablet contains the active components Sofosbuvir and Velpatasvir. It is used to treat chronic hepatitis C. Hepatitis C is a liver infection caused by the hepatitis C virus (HCV). The treatment duration is often shorter than older treatment regimens. The duration can vary depending on factors such as HCV genotype, previous treatment history, and the presence of liver cirrhosis. Successful treatment with Resof total tablet can significantly reduce liver inflammation and fibrosis caused by HCV infection. By achieving viral eradication, the risk of developing liver cirrhosis, liver failure, and hepatocellular carcinoma (a type of liver cancer) can be substantially reduced.
If you have a known allergy or hypersensitivity to Resof total tablet or any of the components of the medication, you should not take it. The safety and efficacy of sofosbuvir and velpatasvir combination therapy have not been established in children under 18. Its use in the pediatric population is currently limited. It is recommended to use alternative treatment options or adjust the Resof Total dosage in these cases. Resof Total price India varies by retailer and location. Resof Total substitutes include other brands containing the same combination of multivitamins and minerals, but should only be used under your doctor’s guidance.
Uses
Resof Total uses are:
- To treat chronic hepatitis C (HCV) infection.
How Resof Total Tablet Works
Sofosbuvir is a direct-acting antiviral drug (DAA) that inhibits the replication of the HCV virus by targeting a specific protein necessary for viral replication. Velpatasvir is also a DAA that works by blocking the action of another protein involved in the HCV replication process.
Interaction of Resof Total Tablet with other drugs
Inform the doctor about your medicines, including prescription, over-the-counter, nutritional or vitamin supplements, and herbal products. Certain medications may interact with Resof total tablet, reducing effectiveness by causing undesirable side effects.
Storage Conditions
- Stored at controlled room temperature, between 20°C to 25°C (68°F to 77°F).
- Keep away from moisture, heat, and light.
- It should not be frozen.
- Keep away from children and pets
How to take Resof Total Tablet
Read the instructions carefully before taking Resof total tablet. Take them as directed by your doctor. Take it with or without food. This will help to improve absorption. If you experience side effects, stop taking them and talk to your doctor.
Safety Advice for Resof Total Tablet
Breast Feeding
Consult Your Doctor
There is limited information about the safety of Resof total tablet in breastfeeding. If you are pregnant or planning to become one, talk to your doctor about the risks and benefits. They can help you decide if they are right for you.
Alcohol
Unsafe
It is generally recommended to avoid alcohol consumption during hepatitis C treatment, including Resof total tablet. Alcohol can potentially worsen liver damage and interfere with the effectiveness of the medication. It is best to consult with your healthcare provider regarding alcohol consumption during treatment.
Liver
Consult Your Doctor
If you have a chronic lung disease, talk to your doctor about the risks and benefits. They can help you decide if Resof total tablet is right for you.
Lungs
Consult Your Doctor
If you have a chronic lung disease and are considering taking Resof total tablet, talk to your doctor about the risks and benefits.
Driving
Unsafe
Common side effects of Resof total tablet include headache, fatigue, and dizziness. Suppose you experience any of these side effects or other symptoms that may impair your ability to drive safely. In that case, you should refrain from driving or operating heavy machinery until you feel fully alert and capable.
Pregnancy
Consult Your Doctor
There is limited information about the safety of Resof total tablet in pregnancy. If you are pregnant and considering taking them, talk to your doctor about the risks and benefits. They can help you decide if they are right for you.
Side Effects
Resof Total side effects like all medications, although not everyone will experience them.
Serious:
- Hepatitis B reactivation
- Severe allergic reactions
Common:
- Headache
- Fatigue
- Nausea
- Insomnia
- Diarrhea
- Itching (pruritus)
- Decreased appetite
- Muscle or joint pain
- Rash
- Dizziness
Expert tips
FAQs about Resof Total Tablet
Q1.
Can Resof total tablet cure hepatitis C in individuals with advanced liver disease or cirrhosis?
Resof Total for hepatitis C shows efficiency in individuals with advanced liver disease or compensated cirrhosis. However, the response rate may vary, and close monitoring of liver function is important during and after treatment.
Q2.
Is it necessary to undergo regular blood tests while on Resof total tablet treatment?
Yes, regular blood tests are typically conducted during Resof total tablet treatment to monitor liver function, viral load, and treatment response. These tests help assess the effectiveness of the medication and ensure patient safety.
Q3.
Can Resof total tablet be used in patients with kidney disease?
Resof total tablet can be used in patients with mild to moderate kidney impairment without dose adjustment. However, patients with severe renal impairment or end-stage renal disease may require dose adjustments or alternative treatment options. It is important to discuss your kidney function with your healthcare provider to determine the most appropriate treatment plan.
Q4.
Can Resof total tablet be used in patients with HIV co-infection?
Resof total tablet is effective and safe in individuals with both hepatitis C and HIV co-infection. However, it is important to coordinate treatment with both infectious disease and HIV specialists to ensure proper management of both conditions.
Q5.
Can Resof total tablet cause weight gain or loss?
Weight gain or loss is not commonly reported as a side effect of the Resof total tablet. However, individual responses to medication can vary. If you experience any unexplained or concerning changes in weight during treatment, it is recommended to consult your healthcare provider for further evaluation.
Q6.
Can Resof total tablet be used in patients with a history of liver transplantation?
Resof total tablet can be used in patients with a history of liver transplantation who have recurrent hepatitis C. However, individual patient factors and the specific post-transplantation period must be considered. Consultation with a transplant hepatologist or specialist is recommended to determine the most appropriate treatment approach.
Q7.
Can Resof total tablet cause any serious side effects?
While Resof total tablet is generally well-tolerated, like any medication, it can potentially cause side effects. Common side effects include headache, fatigue, nausea, and insomnia. Serious side effects are rare but can include severe allergic reactions, changes in heart rate, and liver problems. It is important to discuss any concerns or potential side effects with your healthcare provider, who can provide further information and guidance based on your specific situation.
Fact Box
|
Molecule name: |
Sofosbuvir, Velpatasvir |
|
Therapeutic class: |
Antiviral |
|
Pharmacological class: |
1. Sofosbuvir: Nucleotide analog 2. Velpatasvir: Direct-acting antiviral (DAA) |
|
Indications: |
Chronic hepatitis C (HCV) infection |
References
- Gilead Sciences Ltd, Electronic medicines compendium (EMC), [Revised on Jan 2021] [ Accessed on 24th June 2023], https://www.medicines.org.uk/emc/files/pil.7294.pdf
- Gilead Sciences Inc, US Food and Drug Administration, [Revised on Aug 2017] [Accessed on 24th June 2023], https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/208341s007lbl.pdf
- Sarah L Greig; Sofosbuvir/Velpatasvir: A Review in Chronic Hepatitis C; Drugs; [Published on 24th June 2023]; [Accessed on 24th June 2023]; https://pubmed.ncbi.nlm.nih.gov/27730529/
Disclaimer
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Author Details
Written By
Dr. Archana Gupta
BDS
Reviewed By
Dr. Tejashwin Adiga
MBBS
Last updated : 31 Mar 2026 | 09:30 AM (IST)
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